DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otk and MAG

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_002352.1	Gene:	MAG / 4099	HGNCID:	6783	Length:	626	Species:	Homo sapiens

Alignment Length:	699	Identity:	157/699 - (22%)
Similarity:	227/699 - (32%)	Gaps:	203/699 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 DLEPLEIE--WYRNSEKLSTWKNVQLDQHRLIIRQ--PGSE----DDGLYRCT--ASNAAGRVMS 199
            :|.|..:.  ||.||.....:..|.......::.:  .|..    |.||..||  .||.:..:..
Human    49 ELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGG 113

  Fly   200 KQGYVYQSSVKCLPRLPRRKNEKMMESWDKQTFLCRGKRGGAAGLEALPAAPEDLRIVQGP--IG 262
            |  |.::..               :..:::.||                :....|.||..|  :.
Human   114 K--YYFRGD---------------LGGYNQYTF----------------SEHSVLDIVNTPNIVV 145

  Fly   263 QSIIKEGEPTALTCLYELPDELKNQRIQLRWRKDGKLLRQVELGGSAPIPGHSFDSGKDALLRED 327
            ...:..|....::|:  :||.....|.:|.|      |....||..|.:       |:   ||||
Human   146 PPEVVAGTEVEVSCM--VPDNCPELRPELSW------LGHEGLGEPAVL-------GR---LRED 192

  Fly   328 ARLVLHKQNGT------LSFASIIASDAGQYQCQ-------LQLEAHAPINSSPGILEVIEQLKF 379
                    .||      |.|.....::..:..||       ||.|.:|.::           :|:
Human   193 --------EGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMD-----------VKY 238

  Fly   380 VPQPTSKNLELDAVV---AKVHCKAQGTPTPQVQWVRDGENTTLPDHVEVDANGTLI-FRNVNSE 440
            .|.....|..::|:.   ..:.|.|...|.|.:.|:|||  |.|.:.|   |...|: ...|...
Human   239 PPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDG--TVLREAV---AESLLLELEEVTPA 298

  Fly   441 HRGNYTCLATNSQGQINATVAINVVVTPKFSVPPV-GPIETSEQGTVVMHCQAIGDPKPTIQWDK 504
            ..|.|.|||.|:.||.|.||.::|:..|  ..|.| |.:...|..||.:.|....:|.|.:...|
Human   299 EDGVYACLAENAYGQDNRTVGLSVMYAP--WKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFK 361

  Fly   505 DLKYLSENNTDRERFRFLENGTLEIRNVQVEDEGSYGCTIGNSAGLKREDVQLVVKTTGDGFAPE 569
            :.:.||....:.|.       .||:..|..||:|.|.|...|..|
Human   362 EKQILSTVIYESEL-------QLELPAVSPEDDGEYWCVAENQYG-------------------- 399

  Fly   570 ESGGDGFLVTRAVLITMTVALAYIVLVVGLMLWCRYRRQARKARLNDLSTKEAGGDQPDVA---- 630
                     .||....::|..|.::|   |...|...|...:......|..|     |.||
Human   400 ---------QRATAFNLSVEFAPVLL---LESHCAAARDTVQCLCVVKSNPE-----PSVAFELP 447

  Fly   631 ---GNGKGSEQEPCLSKQHNGHSKSRSKSSGDAQKSDDTACSQQSRASKKSAHIYEQLALPRSGL 692
               .....||:|...|::......|.....|.||......|:.::....||      |.||..|.
Human   448 SRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKS------LELPFQGA 506

  Fly   693 SELIQIGRGEFGDVFV-------------GKLKATLVTSPSDKDADT---------------EKQ 729
            ..|:....|..|.|..             .:.|..:..|||....|.               ||.
Human   507 HRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESPSFSAGDNPPVLFSSDFRISGAPEKY 571

  Fly   730 HSNSENGS-----GGSGSG-----STTLSTLNEKRRSKTSMDDIEEIKE 768
            .|....||     |..|..     |.:.|.|. ||.:|.|....||:.|
Human   572 ESERRLGSERRLLGLRGEPPELDLSYSHSDLG-KRPTKDSYTLTEELAE 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352
		Ig	31..115	CDD:299845
		IGc2	133..195	CDD:197706	15/59 (25%)
		Ig	268..373	CDD:299845	26/117 (22%)
		Ig	395..460	CDD:143165	23/65 (35%)
		I-set	468..559	CDD:254352	24/91 (26%)
		IGc2	484..549	CDD:197706	18/64 (28%)
		PTK_CCK4	686..1026	CDD:133178	29/121 (24%)
		STYKc	692..1020	CDD:214568	26/115 (23%)
MAG	NP_002352.1	Interaction with RTN4R and RTN4RL2. /evidence=ECO:0000250\|UniProtKB:P07722	20..325		79/350 (23%)
		Ig_Siglec_N	22..139	CDD:143189	21/122 (17%)
		Ganglioside GT1b binding. /evidence=ECO:0000250\|UniProtKB:P20917	65..67		0/1 (0%)
		Ganglioside GT1b binding. /evidence=ECO:0000250\|UniProtKB:P20917	124..128		0/3 (0%)
		Ig	141..223	CDD:325142	23/107 (21%)
		Ig_3	239..309	CDD:316449	22/74 (30%)
		IG_like	333..409	CDD:214653	23/111 (21%)
		Required for normal axon myelination in the central nervous system. /evidence=ECO:0000250\|UniProtKB:P20917	577..626		14/44 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	582..608		7/26 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900