DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otk and Nrk

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster

Alignment Length:	644	Identity:	149/644 - (23%)
Similarity:	260/644 - (40%)	Gaps:	142/644 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   435 RNVNSEHRGNYTCLATNSQGQINATVAINVVVTPKFSVPPVGPIETSE-------------QGTV 486
            ||:..:.||::.....:|....||::.     .|..|...:..::.||             .||:
  Fly   172 RNMFIKSRGHFRLPNCSSLPHYNASMR-----RPNCSYIGLTELKESEVSYDCRNGNGRFYMGTM 231

  Fly   487 VMHCQAIGDPKPTIQWDKDLKYLSENNTDRERFRFLENGTLEIRNVQVEDEGSYGCTIGNSAGLK 551
            .:....|    |..:|  |.:|..::......|..|..|....||...|:...:..|:..|...:
  Fly   232 NVSKSGI----PCQRW--DTQYPHKHFQPPLVFHQLLEGENYCRNAGGEEPHPWCYTVDESVRWQ 290

  Fly   552 REDVQLVVKTTGDGFAPEESGGDGFLVTRAV---------------LITMTVALAYIVLV-VGLM 600
            ..|:.:         .|:      ::...||               :|.:...:.::.:| :.||
  Fly   291 HCDIPM---------CPD------YVDPNAVDLNTPIKMEKFFTPSMIFLLAGIGFVAIVTLHLM 340

  Fly   601 LWCRYRRQARK-------ARLNDLSTKEAGGDQPDVAGNGKGSEQEPCLSKQHNGHSKSRSK--- 655
            :...|:....|       |...:.|....||.  |..||...|.:    :...||::.:.:|
  Fly   341 ILLVYKLSKHKDYSQPAGAATAECSVSMRGGG--DCGGNLNTSRE----TLGGNGNTNTLAKWGT 399

  Fly   656 -SSGDAQKSDDTACS-----QQSRASKKSAHIYEQLALPRSGLSELIQIGRGEFGDVFVGKLKAT 714
             .|.....|:..|.:     ..::.:|.:|.: |:|..||..:..:..:|:|.||.||
  Fly   400 IRSTATIHSNCVALTTVTNVSDAKGTKPNARL-EKLEYPRGDIVYVRSLGQGAFGRVF------- 456

  Fly   715 LVTSPSDKDADTEKQHSNSENGSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSGL 779
                                                  :.|:...:.|.|::
  Fly   457 --------------------------------------QARAPGLVPDQEDL------------- 470

  Fly   780 EQLVLVKALNKVKDEQACQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFL 844
              ||.||.|.....:|...:|.|:..||....|..:|||.|:|....|..::.||...|||.:||
  Fly   471 --LVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFL 533

  Fly   845 LATAGKVNTATAGSSSPPPLTTSQVLAVAYQIARGMDAIYRARFTHRDLATRNCVISSEFIVKVS 909
            .| .....|..|.:.....|....:|.:|..||.||..:...:|.|||||||||:|:....||::
  Fly   534 RA-CSPYATHQAPTQDRLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIA 597

  Fly   910 YPALCKDKYSREYHK-HRNTLLPIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQATKLPHEEL 973
            ...|....|.::|:| ..|..:||||:..|.|..::::.:||::|||:.:||:|:.|.: |:..|
  Fly   598 DFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQ-PYFGL 661

  Fly   974 TNEQVVQRSQAGSLEWSVAEATPDSLREILLSCWVSNPKERPSFSQLGAALSKAMQSAE 1032
            |:|:|::..:.|:: ....:.||.|:..::..||...|.|||.|:::...:..::..:|
  Fly   662 THEEVIKYIKEGNV-LGCPDNTPLSVYALMRRCWNRKPSERPGFAEINHCIQHSIAESE 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352
		Ig	31..115	CDD:299845
		IGc2	133..195	CDD:197706
		Ig	268..373	CDD:299845
		Ig	395..460	CDD:143165	7/24 (29%)
		I-set	468..559	CDD:254352	20/103 (19%)
		IGc2	484..549	CDD:197706	15/64 (23%)
		PTK_CCK4	686..1026	CDD:133178	94/340 (28%)
		STYKc	692..1020	CDD:214568	92/328 (28%)
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308	9/44 (20%)
		KR	217..299	CDD:214527	16/96 (17%)
		PTKc_Musk	435..713	CDD:133181	94/340 (28%)
		Pkinase_Tyr	441..707	CDD:285015	92/328 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1026
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810