DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otk and otk2

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_612571.1	Gene:	otk2 / 36284	FlyBaseID:	FBgn0267728	Length:	433	Species:	Drosophila melanogaster

Alignment Length:	428	Identity:	230/428 - (53%)
Similarity:	290/428 - (67%)	Gaps:	29/428 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 ALPAAPEDLRIVQGPIGQSIIKEGEPTALTCLYELPD-ELKNQRIQLRWRKDGKLLRQVELGGSA 309
            |.||:.||:.|.:||.....|||.....|.|.|:||| .|:...:.||||||.|.|||||||
  Fly    25 AAPASFEDVSISRGPKSSITIKEQSSLQLPCDYQLPDGYLQKSSVILRWRKDSKTLRQVELG--- 86

  Fly   310 PIPGHSFDSGKDALLREDARLVLHKQNGTLSFASIIASDAGQYQCQLQLEAHAPINSSPGILEVI 374
            .:...:.:...:.:||||:|:.|.|.:|.|.|.|::|||||||||||.::.....:||.|:|.||
  Fly    87 RMDSTTSEPQLETMLREDSRVALSKDSGALQFTSVLASDAGQYQCQLVIDDSVAASSSSGVLLVI 151

  Fly   375 EQLKFVPQPTSKNLELDAVVAKVHCKAQGTPTPQVQWVRDGENTTLPDHVEV-DANGTLIFRNVN 438
            |||||||||||||||| ..::||||||||||.|||:|:|:   |.||..|.| |.||||||..|:
  Fly   152 EQLKFVPQPTSKNLEL-GTLSKVHCKAQGTPAPQVKWMRE---TQLPLPVNVTDQNGTLIFNQVS 212

  Fly   439 SEHRGNYTCLATNSQGQINATVAINVVVTPKFSVPPVGPIETSEQGTVVMHCQAIGDPKPTIQWD 503
            :|.||.|||:|:||||||.|||:|||||.|||||||.||||.:|.||.|:||||||:||||||||
  Fly   213 NEQRGQYTCIASNSQGQITATVSINVVVAPKFSVPPEGPIEVAEAGTAVIHCQAIGEPKPTIQWD 277

  Fly   504 KDLKYLSENNTDRERFRFLENGTLEIRNVQVEDEGSYGCTIGNSAGLKREDVQLVVKTTGDGFAP 568
            |||.||:|||||.|||..:||||||||||:.||||.||||||:|||||||||.||:|::
  Fly   278 KDLTYLNENNTDPERFSLMENGTLEIRNVRPEDEGRYGCTIGSSAGLKREDVLLVLKSS------ 336

  Fly   569 EESGGDGFLVTRAVLITMTVALAYIVLVVGLMLWCRYRRQARKARLNDLSTK-EAGGDQPDVAGN 632
              ......:|||.:::.:.:|..|.|||:||.:|.||||...|.:|.|.... ...|.:.|
  Fly   337 --KSASNSIVTRIIIVIICLAFLYFVLVLGLKVWYRYRRHLGKVQLEDGHVNGPTDGQEHD---- 395

  Fly   633 GKGSEQEPCLSKQHNGHS-KSRSKSS----GDAQKSDD 665
              ..|.||||::.::..: ||:.:.|    .::|.:||
  Fly   396 --HHENEPCLTEANSSKNLKSKLRESTILEQESQVADD 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352
		Ig	31..115	CDD:299845
		IGc2	133..195	CDD:197706
		Ig	268..373	CDD:299845	48/105 (46%)
		Ig	395..460	CDD:143165	42/65 (65%)
		I-set	468..559	CDD:254352	72/90 (80%)
		IGc2	484..549	CDD:197706	51/64 (80%)
		PTK_CCK4	686..1026	CDD:133178
		STYKc	692..1020	CDD:214568
otk2	NP_612571.1	IG_like	41..132	CDD:214653	43/93 (46%)
		I-set	155..238	CDD:254352	58/86 (67%)
		IGc2	175..228	CDD:197706	34/55 (62%)
		IG_like	250..331	CDD:214653	64/80 (80%)
		IGc2	258..323	CDD:197706	51/64 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449281
Domainoid	1	1.000	69	1.000	Domainoid score	I9605
eggNOG	1	0.900	-	-		E1_KOG4475
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245153at33208
OrthoFinder	1	1.000	-	-		FOG0007317
OrthoInspector	1	1.000	-	-		otm26203
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.750