DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otk and dpy

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster

Alignment Length:	489	Identity:	89/489 - (18%)
Similarity:	137/489 - (28%)	Gaps:	148/489 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   356 LQLEAHAPINSSPGILEVIEQLKFVP--------------------------QPTSKNLELDAVV 394
            |:...:.||.|:.|  :|.||....|                          .|.:..|..| ..
  Fly  5428 LETTTNVPIGSTGG--QVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTLPSD-FT 5489

  Fly   395 AKVHCKAQGTPTPQVQWVRDGE---------NTTLPD-------HVEVDANGTLIFRNVNSEHRG 443
            .:.|.:.....|..|...|..|         .||:|.       :|.:.:.|            |
  Fly  5490 TRPHSEQTTESTRDVPTTRPFEASTPSSASLETTVPSVTLETTTNVPIGSTG------------G 5542

  Fly   444 NYTCLATNSQGQINATVAINVVVTPKFSVPPVGPIETSEQGTVVMHCQAIGDPKPTIQWDKDLKY 508
            ..|...|:|..:...|:.:.....|..|.....|.|:.|              .||:..|...:.
  Fly  5543 QVTEQTTSSPSEFRTTIRVEESTLPSRSADRTTPSESPE--------------TPTLPSDFTTRP 5593

  Fly   509 LSENNTDRER----FRFLENGT-----LEIRNVQVEDEGSYGCTIGNSAGLKREDVQLVVKTTGD 564
            .||..|:..|    .|..|..|     ||.....|..|.:....||::.|          :.||.
  Fly  5594 HSEQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGG----------QVTGQ 5648

  Fly   565 GFAPEESGGDGFLVTRAVLITMTVALAYIVLVVGLMLWCRYRRQARKARLNDLSTKEAGGDQPDV 629
            ..||...            :..|:               |.......:|..|.:|.....:.|.:
  Fly  5649 TTAPPSE------------VRTTI---------------RVEESTLPSRSTDRTTPSESPETPTI 5686

  Fly   630 AGNGKGSEQEPCLSKQHNGHSKSRSKSSGDAQKSDDTACSQQSRASKKSAHIYEQLALPRSGLSE 694
            ..:                .|.:|:.|....:.:.|...::...||..|....| ..:|...|..
  Fly  5687 LPS----------------DSTTRTYSDQTTESTRDVPTTRPFEASTPSPASLE-TTVPSVTLET 5734

  Fly   695 LIQIGRGEFGDVFVGKLKATLVTSPSD------KDADTEKQHSNSENGSGGSGSGSTTL----ST 749
            ...:..|..|....|:..||    ||:      .:..|....|........|....|||    :|
  Fly  5735 TTNVPIGSTGGQVTGQTTAT----PSEVRTTIGVEESTLPSRSTDRTSPSESPETPTTLPSDFTT 5795

  Fly   750 LNEKRRSKTSMDDIEEIKEEEQDQHNQSGLEQLV 783
            .....::..|..|:...:..|....:.:.||..|
  Fly  5796 RPHSDQTTESTRDVPTTRPFEASTPSPASLETTV 5829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352
		Ig	31..115	CDD:299845
		IGc2	133..195	CDD:197706
		Ig	268..373	CDD:299845	5/16 (31%)
		Ig	395..460	CDD:143165	14/80 (18%)
		I-set	468..559	CDD:254352	22/99 (22%)
		IGc2	484..549	CDD:197706	16/73 (22%)
		PTK_CCK4	686..1026	CDD:133178	22/108 (20%)
		STYKc	692..1020	CDD:214568	21/102 (21%)
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572	11/60 (18%)
		DUF4758	5445..5650	CDD:292572	45/241 (19%)
		DUF4758	5700..5877	CDD:292572	27/135 (20%)
		DUF4696	5756..6396	CDD:292395	14/74 (19%)
		DUF4758	5802..5979	CDD:292572	6/28 (21%)
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900