DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otk and Siglec1

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	XP_017447235.1	Gene:	Siglec1 / 311426	RGDID:	1311953	Length:	1708	Species:	Rattus norvegicus

Alignment Length:	1117	Identity:	215/1117 - (19%)
Similarity:	341/1117 - (30%)	Gaps:	401/1117 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VLASSSRFQRVPQSQSVVENESVKFECESTDSYSEL-HYDWLHNGHRIAYDKRVHQIGSNLHIEA 83
            :|.|||       .::::....|...|....||..: ..||:.:|..:.....|.|:.|
  Rat   244 ILLSSS-------GRNILPGNLVTLTCRVNSSYPAVSSVDWVKDGVNLTAKGHVLQLSS------ 295

  Fly    84 VRRTEDVGNYVCIATNLASGAREASPPAKLSVI-----------YLESASVQLLGSNRNELLLKC 137
             ....|.|.|.|.|||.....  ||||..|.|.           .||:.:|.||.|...|.
  Rat   296 -ATWNDSGVYTCQATNNVGSL--ASPPLSLHVFMAEVKINPAGPILENETVTLLCSTPKEA---- 353

  Fly   138 HVEGASGDLEPLEIEWYRNSEKLSTWKNVQL-DQHRLIIRQPG--SEDDGLYRCTASNAAGR--- 196
                    .:.|...||:|        |:.| |.|...:..|.  ..|.|.|.|...|..|.
  Rat   354 --------PQELRYSWYKN--------NILLEDAHAPTLHLPAVTRADTGFYFCEVQNTQGSERS 402

  Fly   197 ------------------------------------------VMSKQGYVYQS-----------S 208
                                                      |:|..|....|           |
  Rat   403 GPVSVVVRYPPLTPDLTTFLETQAGLVGIFHCSVISEPLATVVLSHGGLTLASSSGENDFNPRFS 467

  Fly   209 VKCLPRLPRRKNEKMMESWDKQTFLCRGKRGGAAGLEALPAAPEDLRIVQGPIGQSIIKEGEPTA 273
            :...|...|.:...:..: |...:.|.........:.:|.......|::..|..:  :.||:...
  Rat   468 ISSAPNSVRLEIRDLQPA-DSGEYTCSATNSLGKSMSSLDFHANVARLLISPSKE--VVEGQAVT 529

  Fly   274 LTC---LYELPDELKNQRIQLRWRKDGKLLRQVELGGSAPIPGHSFDSGKDALLREDARLVLHKQ 335
            |:|   |...||      .:..|..:|.||    |.||:                         .
  Rat   530 LSCRSGLNPAPD------TRFSWYLNGALL----LEGSS-------------------------S 559

  Fly   336 NGTLSFASIIASDAGQYQCQLQLEAHAPINSSPGILEVIEQLKFVPQPTSKNLELDAVVAK---- 396
            |..|..||  ::|:|.|.|:.:...|....|.|.:|.|.    :.|:..:....||...:.
  Rat   560 NFLLPAAS--STDSGSYYCRARAGPHTSGPSLPTVLTVF----YPPRKLTFTARLDLDTSGDGDG 618

  Fly   397 ----VHCKAQGTPTPQVQWVRDGE--NTTLPDHVEVDANGTLIFRNVNS----------EHRGNY 445
                :.|:....|..|:|.:..|.  .|:||......:....:.|..||          |..|.|
  Rat   619 RRGILLCQVDSDPPAQLQLLHKGHVVATSLPSMCGSCSRRMKVSRASNSLQVEIQKPVLEDEGMY 683

  Fly   446 TCLATNSQGQINATVAIN-----VVVTP------------------KFSVPPV------------ 475
            .|.|:|:.|..:.:.:.|     ||:||                  :.:|.|.
  Rat   684 LCEASNTLGNSSVSASFNAKATVVVITPSDTLLEGTEASLTCNVTQEVAVSPANFSWFRNGVLWT 748

  Fly   476 -GPIET------SEQGTVVMHCQAIGDPKP--------TIQWDKD-------------------- 505
             ||:||      :.....|..|:.:.|...        ::|:..|
  Rat   749 QGPLETVRLQPLARTDAAVYACRLLTDDGAQLSAPVVLSVQYAPDPPKLSALLDVGQGHMAVFIC 813

  Fly   506 ------LKYLSENNTDRERFRFLE-----NG-----------TLEIRNVQVEDEGSYGCTIGNSA 548
                  |.:||....:|.....||     :|           .||:|.:.:||.|:|.|...|..
  Rat   814 TVDSYPLAHLSLFRGERLLATSLEPQRLSHGRIQAKATANSLQLEVRELGLEDSGNYHCEATNVL 878

  Fly   549 GLKREDVQLVVKTTGDGFAPEESGGDGFLVTRAVLITMTV------ALAYIVLVVGLMLWCRYRR 607
            |.....:...|:......:|.....:|    :||:::..|      ..:|        .|.:..|
  Rat   879 GSANSSLFFQVRGAWVQVSPSPELREG----QAVVLSCQVPTGVPEGTSY--------RWFQDGR 931

  Fly   608 QARKA-----RLNDLSTKEAGGDQPDVAGNGKGSEQEPCLSKQHNGHSKSRSKSSGDAQKSDDTA 667
            ..:::     |:..:|.::||.                       .|.::         ::.|||
  Rat   932 PLQESTSSILRIAAISLRQAGA-----------------------YHCQA---------QAPDTA 964

  Fly   668 CSQQSRASKKSAHI-YEQLALPRS-GLSELIQIGRGEFGDVFV---------------GKLKATL 715
            .:  |.|:..|.|: |    .||. .||.|:..|.|.:|.:..               .:|.|:.
  Rat   965 AA--SLAAPVSLHVSY----TPRHVTLSALLSTGPGRYGHLVCSAQSDPPALLRLFHQNRLVAST 1023

  Fly   716 VTSPSDKDADTEKQH----SN--------SENGSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIK- 767
            :..|.:..:...:.|    ||        :|...||:.:...| :||.:  .|.|:..|.:.::
  Rat  1024 LQGPEELASSNPRLHVAVSSNELRLEIQFTELEDGGTYTCEAT-NTLGQ--ASATADFDAQAVRV 1085

  Fly   768 -------EEEQDQHNQSGLEQLVLVKALNKVKDEQACQEFRRQLDLLRAISHKGVVRLFGLCREK 825
                   .:|..|.|.|                   |..:....|.|....:||..:|.|:....
  Rat  1086 AVWPNATVQEGQQVNLS-------------------CLAWSTHQDSLSYTWYKGGQQLLGVRSIS 1131

  Fly   826 DPHYMVLEYTDWGDLKQFLLATAGKVNTATAGSSSPPPLTTSQVLAVAYQIARGMDAIYRARFTH 890
            .|...|.:            ||:.:......|.:  |.|:....|.|.| ..|.:...|......
  Rat  1132 LPSVTVSD------------ATSYRCGVGLPGHT--PHLSRPVTLDVLY-APRSLQLTYLLESQG 1181

  Fly   891 RDLATRNCVISS 902
            |.||...|.:.|
  Rat  1182 RRLALVLCTVDS 1193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352	22/89 (25%)
		Ig	31..115	CDD:299845	22/84 (26%)
		IGc2	133..195	CDD:197706	14/64 (22%)
		Ig	268..373	CDD:299845	26/107 (24%)
		Ig	395..460	CDD:143165	18/84 (21%)
		I-set	468..559	CDD:254352	29/177 (16%)
		IGc2	484..549	CDD:197706	21/114 (18%)
		PTK_CCK4	686..1026	CDD:133178	51/253 (20%)
		STYKc	692..1020	CDD:214568	49/246 (20%)
Siglec1	XP_017447235.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810