DRSC/TRiP Functional Genomics Resources

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Protein Alignment otk and Cd22

DIOPT Version :9

Sequence 1:NP_523705.2 Gene:otk / 36283 FlyBaseID:FBgn0004839 Length:1033 Species:Drosophila melanogaster
Sequence 2:NP_001100973.1 Gene:Cd22 / 308501 RGDID:1311610 Length:852 Species:Rattus norvegicus


Alignment Length:799 Identity:155/799 - (19%)
Similarity:273/799 - (34%) Gaps:244/799 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 VPQSQSVVENESVKFECESTDSYSELHYDWLHNGHRIA-YDKRVHQIGSNLHIEA-----VRRTE 88
            :.:||.|.....:.|.|...|    :...|..:|..:: ....:.....|::.|:     .:.|:
  Rat   157 IRESQRVSLTCGLNFTCFGYD----ISLRWSLDGSEVSPVTSSITSSVENVYTESKLTFQPKWTD 217

  Fly    89 DVGNYVCIATNLASGAREASPPAKLSVIYLESASVQLLGS---NRNELLLKCHVEGASGDLEPLE 150
            ...:.:|...:.:....|.:  .:|.|.|.....:.:..:   ..|.:.:.|.|..::..|...:
  Rat   218 HGKSMMCQVWHFSQVLSERT--VRLDV
KYTPKLQITVNPTEVKEGNSVTMTCQVNSSNPSLSTKK 280

  Fly   151 IEWYRNSEKLSTWKNVQLDQHRLIIRQPGSEDDGLYRCTASNAAGRVMSKQ-------------G 202
            :.|:::...|..    |.:|..|.:.....:..|.|:|.|||..|:..||:             .
  Rat   281 VSWFKDGSFLKE----QQEQEELTLHSVTKDMRGKYQCRASNNIGQGQSKEVALTVLYPPEPSKV 341

  Fly   203 YVYQS------SVKCL------PR------------LPRRKNEKMMES----WDKQTFLCRGK-R 238
            ::|.|      ||:.:      ||            :|...:||:..|    |....:.|..: |
  Rat   342 HIYPSPAEEGQSVELICDSLASPRATNYTWYHNGEMVPGASHEKLQISNVSLWHAGKYSCLAENR 406

  Fly   239 GGAAGLEALPAAPEDLRIVQGPIG---QSI--IKEGEPTALTCLYEL--PDELKNQRIQLRWRKD 296
            .|...:|  ..|..|:..|...:.   ||:  |:||:...|.|.|..  |:..|.:     |...
  Rat   407 LGCGKIE--QEAELDVHYVPKAVTTVIQSVTPIREGDSVTLDCRYNSSNPEVTKYE-----WSPQ 464

  Fly   297 GKLLRQVELGGSAPIPGHSFDSGKDALLREDARLVLHKQNGTLSFASIIASDAGQYQCQLQLEAH 361
            |        .||...||                 ||..|..|.....|..: |..|:|.......
  Rat   465 G--------SGSEVTPG-----------------VLRIQKATWDSPPIKCA-ACNYKCSWSFPVS 503

  Fly   362 APINSSPGILEVIEQLKFVPQPTSKNLELDAVVAKVH--------CKAQGTPTPQVQ--WVRDGE 416
            ..::.:|..:::   ||..|            .:::|        |...|:...:|:  |.::|.
  Rat   504 LNVHYAPRAVKI---LKVSP------------ASEIHAGQHVLLQCDFSGSFPTEVRFFWKKNGN 553

  Fly   417 NTTLPDHVEVDANGTLIFRNVNSEHRGNYTCLATNSQGQINATV-AINVVVTP---KFSVPPVGP 477
                    .|.....|.|.:::.|..|||.|:..||.|:.::.. ::.|:..|   :.|:.|...
  Rat   554 --------LVQEGRYLNFSSISPEDSGNYNCMVRNSIGETSSQAWSLQVLYAPRRLRVSISPGDS 610

  Fly   478 IETSEQGTVVMHCQAIGDPKPTIQW------DKDLKYLSENNTDRERFRFLENGTLEIRNVQVED 536
            :...::.|  :.|::...| |..::      |:||.:..:.              |.:..::|:.
  Rat   611 VMEGKKAT--LSCESDAHP-PVFKYIWFDANDQDLHFSGQK--------------LRLEPLRVQH 658

  Fly   537 EGSYGCTIGNSAGL-KREDVQLVVKTTGDGFAPEESGGDGFLVTRAVLITMTVALAYIVLVV-GL 599
            .|||.|...|..|. |.....|.|.     ::||..|       :.|.:.:...||..:|.: |:
  Rat   659 TGSYRCQGINELGTGKSPPSTLTVY-----YSPETIG-------KRVALGLGFCLAICILAIWGM 711

  Fly   600 ML---WCRYRRQ------------------ARKARLNDLSTKEAGGDQ----------------- 626
            .:   |...|.|                  ||:.||.:       |.|                 
  Rat   712 KIQKKWKHNRSQQGPQDNSSGQSFFVRNKKARRTRLTE-------GPQSQGCYNLAMDDTVSYAV 769

  Fly   627 ---PDVAGNGKGSEQEPCLSKQHNGHSKSRSKSSGDAQKSDDTACSQQSRASKKSAHIYEQLA-- 686
               |:...:|.|..:.|.              :.|.....|||.  ..|...|::...||.::  
  Rat   770 LRFPESDTHGAGGARSPA--------------TQGPPPNDDDTV--TYSVLQKRNMGDYENVSPN 818

  Fly   687 LPRS---GLSELIQIGRGE 702
            .|..   ..|||:|.|.|:
  Rat   819 CPEDESIHYSELVQFGAGK 837

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
otkNP_523705.2 I-set 26..115 CDD:254352 14/90 (16%)
Ig 31..115 CDD:299845 14/89 (16%)
IGc2 133..195 CDD:197706 14/61 (23%)
Ig 268..373 CDD:299845 22/106 (21%)
Ig 395..460 CDD:143165 17/74 (23%)
I-set 468..559 CDD:254352 20/100 (20%)
IGc2 484..549 CDD:197706 14/70 (20%)
PTK_CCK4 686..1026 CDD:133178 7/22 (32%)
STYKc 692..1020 CDD:214568 6/11 (55%)
Cd22NP_001100973.1 Ig 24..143 CDD:416386
FR1 24..47 CDD:409353
Ig strand A 24..28 CDD:409353
Ig strand A' 31..35 CDD:409353
Ig strand B 37..48 CDD:409353
CDR1 48..56 CDD:409353
Ig strand C 56..63 CDD:409353
FR2 57..63 CDD:409353
CDR2 64..95 CDD:409353
Ig strand C1 65..68 CDD:409353
Ig strand C2 71..75 CDD:409353
Ig strand C' 79..82 CDD:409353
FR3 96..129 CDD:409353
Ig strand D 97..101 CDD:409353
Ig strand E 106..114 CDD:409353
Ig strand F 121..129 CDD:409353
CDR3 130..132 CDD:409353
FR4 133..143 CDD:409353
Ig strand G 133..143 CDD:409353
IgC1_CD22_d2 147..242 CDD:409532 14/90 (16%)
Ig strand B 163..167 CDD:409532 1/3 (33%)
Ig strand C 179..183 CDD:409532 0/3 (0%)
Ig strand E 207..211 CDD:409532 0/3 (0%)
Ig strand F 221..226 CDD:409532 1/4 (25%)
Ig strand G 235..238 CDD:409532 1/4 (25%)
Ig 246..334 CDD:416386 18/91 (20%)
Ig strand A 246..253 CDD:409353 0/6 (0%)
Ig strand B 260..270 CDD:409353 2/9 (22%)
Ig strand C 277..285 CDD:409353 1/7 (14%)
Ig strand C' 287..290 CDD:409353 0/2 (0%)
Ig strand E 296..303 CDD:409353 2/6 (33%)
Ig strand F 310..318 CDD:409353 4/7 (57%)
Ig strand G 321..334 CDD:409353 3/12 (25%)
IGc2 350..408 CDD:197706 11/57 (19%)
Ig strand B 354..358 CDD:409353 1/3 (33%)
Ig strand C 367..372 CDD:409353 0/4 (0%)
Ig strand F 398..403 CDD:409353 1/4 (25%)
Ig 424..>466 CDD:416386 12/54 (22%)
Ig strand A 424..431 CDD:409353 0/6 (0%)
Ig strand A' 435..439 CDD:409353 1/3 (33%)
Ig strand B 440..450 CDD:409353 3/9 (33%)
Ig strand C 457..463 CDD:409353 2/10 (20%)
IGc2 527..583 CDD:197706 15/63 (24%)
Ig strand B 530..534 CDD:409353 0/3 (0%)
Ig strand C 543..549 CDD:409353 1/5 (20%)
Ig strand F 573..578 CDD:409353 3/4 (75%)
IG 610..682 CDD:214652 17/88 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4475
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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