DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment otk and Il18r1

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_001100375.1	Gene:	Il18r1 / 301365	RGDID:	1308589	Length:	537	Species:	Rattus norvegicus

Alignment Length:	405	Identity:	94/405 - (23%)
Similarity:	144/405 - (35%)	Gaps:	109/405 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   266 IKEGEPTAL-TCLYELPDELKNQRIQLRWRKDGKLLRQVELGGSAPIPGHSFDSGKDALLREDAR 329
            :.||||..| .|....|.. .|:...:||.|           |:|   .|.:   ::..:|...|
  Rat    30 VVEGEPFYLKPCDMSAPMH-NNETATMRWFK-----------GNA---SHGY---RELNMRSSPR 76

  Fly   330 LVLHKQNGTLSFASIIASDAGQYQCQLQLEAHAPINSSPGILEVIEQLKFVPQPTSKNLELDAVV 394
            :..|  ...|.|..:...|.|.|..|:..:                         .:|..|:...
  Rat    77 IAFH--GHALEFWPVELEDKGTYFSQVGND-------------------------RQNWTLNVTK 114

  Fly   395 AKVH-CKAQGTPTPQVQWVRDG-----ENTTLPDHVEVDANGTLIFRNVNSEHR----------- 442
            ...| |.::...|.:...|:..     ||   |.:.|: .|.||:::|.....:
  Rat   115 RNKHSCFSEKLVTNRDVEVKKSLWITCEN---PSYGEL-INHTLLYKNCKEISKTPMILKDAEFG 175

  Fly   443 --GNYTCLAT---NSQGQINATVAINVVV-------TPKF---SVPPVGPIETSEQGTVVMHCQA 492
              |.|:|:.:   |.| |.|.|..:|:.|       ||..   ....|| :|..|.  |.::|.|
  Rat   176 DEGYYSCVFSVHHNGQ-QYNITKTVNITVIEGNSKITPAIFGSKSAKVG-VELGED--VELNCSA 236

  Fly   493 IGDPKPTIQWD-KDLKYLSEN-NTDRERFRFLENGTL---EIRNVQVEDEG----SYGCTIGNSA 548
            :.:......|. :....|..| :.||....:...|.|   :|..:|...|.    .|.||:.|..
  Rat   237 VLNRNDLFYWSIRKEDSLDPNVHEDRNETTWTFEGKLHASKILRIQKVTEKYLNVLYNCTVANEE 301

  Fly   549 GLKREDVQLVVKTTGDGFAPEESGGDGFL--VTRAVLITMT---VALAYIVLVVGLMLWCRYRRQ 608
            ....:...||.|.|.|      ..|..|:  :|..||.::.   |.:..|:..|.|:|:  |||.
  Rat   302 ATDTKSFILVRKETPD------IQGHVFMRGITMVVLTSVAAVCVVILCIIYKVDLVLF--YRRV 358

  Fly   609 A-RKARLNDLSTKEA 622
            | |...|.|..|.:|
  Rat   359 AERDETLTDGKTYDA 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352
		Ig	31..115	CDD:299845
		IGc2	133..195	CDD:197706
		Ig	268..373	CDD:299845	23/105 (22%)
		Ig	395..460	CDD:143165	19/86 (22%)
		I-set	468..559	CDD:254352	23/102 (23%)
		IGc2	484..549	CDD:197706	17/73 (23%)
		PTK_CCK4	686..1026	CDD:133178
		STYKc	692..1020	CDD:214568
Il18r1	NP_001100375.1	Ig_2	22..112	CDD:290606	25/126 (20%)
		Ig	<156..205	CDD:299845	11/49 (22%)
		IG_like	224..310	CDD:214653	19/87 (22%)
		TIR	370..519	CDD:214587	2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910