DRSC/TRiP Functional Genomics Resources

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Protein Alignment otk and Hmcn1

DIOPT Version :9

Sequence 1:NP_523705.2 Gene:otk / 36283 FlyBaseID:FBgn0004839 Length:1033 Species:Drosophila melanogaster
Sequence 2:NP_001258221.1 Gene:Hmcn1 / 289094 RGDID:1564772 Length:5635 Species:Rattus norvegicus


Alignment Length:1246 Identity:258/1246 - (20%)
Similarity:418/1246 - (33%) Gaps:418/1246 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 ISICGLVMALMMASVLASSSRFQRVPQSQSVVENESVKFECESTDSYSELHYDWLHNGHRIAYDK 70
            :::.|||..|:..|           |...||:|.:.:...|............|:.|...:..:.
  Rat   882 VTVTGLVAPLIGIS-----------PSKASVIEGQPLTLPCTLLAGNPIPERRWMKNSAMLVQNP 935

  Fly    71 --RVHQIGSNLHIEAVRRTEDVGNYVCIATNLASGAREASPPAKLSVIYLESASVQLLGSNRN-E 132
              .|...|| ||||.| |.:|.|.|.|:|:|:| |....:....:.|:.......|:|.:... .
  Rat   936 YITVRSDGS-LHIERV-RLQDGGEYTCVASNVA-GTNNKTTSVAVHVLPTIQHGQQILSTIEGVP 997

  Fly   133 LLLKCHVEGASGDLEPLEIEWYRNSEKLSTWKNVQLD---QHRLIIRQPGSEDDGLYRCTASNAA 194
            :.|.|.   |||..:| .|.|.:..|.:|| .|.:..   ...|.:..||||:.|.|.|||:|||
  Rat   998 VTLPCR---ASGIPKP-SITWSKKGELIST-GNAKFSAGADGSLYVVSPGSEESGEYICTATNAA 1057

  Fly   195 GRVMSK-QGYVY--------------------------QSSVKC------LPRLPRRKNEKMMES 226
            |....| |..||                          ::::.|      .|.:...|:.:::..
  Rat  1058 GYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEATLPCEAKSLPPPIITWAKDSQLISP 1122

  Fly   227 WD-KQTFLCRGK------RGGAAGL--------------------EALPAAPEDLRIVQGPIGQS 264
            :. :.|||..|.      |...:|:                    ...|......|.::..:||.
  Rat  1123 FSPRHTFLPSGSMKITETRISDSGMYLCVATNIAGNVTQSVKLSVHVPPKIQHGNRHLKVQVGQR 1187

  Fly   265 I----------------IKEGEP--------------------TAL------TC----------- 276
            :                .|.|.|                    |.|      ||           
  Rat  1188 VDIPCNAHGSPPPVITWFKSGRPMPFNGVQHPGSPDGMLTIEQTTLSDAGTYTCTATNIAGSDEA 1252

  Fly   277 -----LYELP--------------DELKNQRI------------QLRWRKDGKLLRQVELGGSAP 310
                 :.|.|              :.|.|||:            .::|..:||     |:.|.. 
  Rat  1253 EVTLHVQEPPTVEDLQPPFNTPFQERLANQRMAFPCPAKGTPKPTIKWLHNGK-----EVTGQE- 1311

  Fly   311 IPGHSFDSGKDALLREDARLVLHKQNGTLSFASIIASDAGQYQCQLQLEAHAPINSSPGILEVIE 375
             ||.|       :|.:.|.||:         ||:...:.|:|.|....||        |..|...
  Rat  1312 -PGVS-------ILEDGALLVI---------ASVTPLNNGEYICVAVNEA--------GTTERKY 1351

  Fly   376 QLKFVPQPTSKNLE-------LDAVVAKVHCKAQGTPTPQVQWVRDGENTTLPDHVEVDANGTL- 432
            .|:....|..|:.|       |...:|.::|:.:|||:|.:.|.:|....|....|::..||.: 
  Rat  1352 NLRVHVPPVIKDKEHVSNVSVLVNQLASLYCEVEGTPSPVIMWYKDDIQVTESSTVQIVNNGKIL 1416

  Fly   433 -IFRNVNSEHRGNYTCLATNSQGQINATVAINVVVTPKFSVPPVG-PIETSE--QGTVVMHCQAI 493
             :|: .::|..|.|:|.|.|..|......::||:|.|  |:...| |.|.|.  ...:.:.|...
  Rat  1417 KLFK-ASAEDTGRYSCKAINIAGTSQKDFSVNVLVPP--SIQGAGSPNEVSVVLNHNITLQCPVR 1478

  Fly   494 GDPKPTIQWDKDLK--YLSENN---TDRERFRFLENGTLEIRNVQVEDEGSYGCTIGNSAGLKRE 553
            |.|.|.|.|.||.|  :|.:.|   :||.:       .|.:||.:..|:|.|.|::.|:||.:.:
  Rat  1479 GTPFPAIHWFKDGKPLFLGDPNIELSDRGQ-------NLHLRNARRSDKGRYQCSVSNAAGKQAK 1536

  Fly   554 DVQLVVKTTGDGFAPEESGGDGFLVTRAVLITMTVALAYIVLVVGLMLWCRYRRQARKARLNDLS 618
            |::|.:      :.|....|.......:.|:...|.|.           |..|            
  Rat  1537 DIKLTL------YVPPSIKGGNVTTEISALLNSVVKLE-----------CETR------------ 1572

  Fly   619 TKEAGGDQPDVAGNGKGSEQEPCLSKQHNGHSKSRSKSSGDAQKSDDTA----CSQQSRASKKSA 679
                |...|.:.....|  |....|.|.....|.:......||.||...    .|..:..::||.
  Rat  1573 ----GLPVPAITWYKDG--QVVTSSSQALYIDKGQFLHIPRAQVSDSATYTCHASNVAGTAEKSF 1631

  Fly   680 HIYEQLALPRSGLSELIQIGRGEFGDVFVGKLKATLVTSPSDKDADTEKQHSNSENGSGGS---- 740
            |:                       |::|..:....:|:||.|....           |.|    
  Rat  1632 HV-----------------------DIYVPPIIEGDLTTPSSKQVVV-----------GQSLVLE 1662

  Fly   741 ----GSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSGLEQLVLVKALNKVKDEQAC---- 797
                |:....|:.|.:....|.| |:|          |.::|.::|.::.||...:.:..|    
  Rat  1663 CKAVGNPPPVLTWLKDGVPVKAS-DNI----------HIEAGGKKLEILSALEVDRGQYICVATS 1716

  Fly   798 ----QEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFLLATAGK-VNTATAG 857
                :|.:.::|:|                       |....:.||...:.:..|.. :......
  Rat  1717 VAGEREIKYEVDVL-----------------------VPPAVEGGDETSYFIVLANNLLELDCQV 1758

  Fly   858 SSSPPP----LTTSQVL--AVAYQIARGMDAIYRARFTHRDLATRNCVISS-------EFIVKVS 909
            |.||||    |...|::  ...::|......:..|:....|.....||.::       ||.|.|.
  Rat  1759 SGSPPPTIMWLKGGQLIDERDGFKILLSGRKLVIAQAQVSDTGLYQCVATNVAGDRRKEFEVTVH 1823

  Fly   910 YPALCKDKYSREYHKHRNTLLPIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQATKLPHEELT 974
            .|...|.....|     .|::..:.::.:||                        |..:|:..:|
  Rat  1824 VPPTIKSSDLPE-----KTVVRYKPVSLQCI------------------------ANGIPNPSIT 1859

  Fly   975 ---NEQVVQ------RSQAGSLEWSVAEA-TPDSLREILLSCWVSNP------------KERPSF 1017
               ::|.|.      |.|:......:|:| ..|:.|   .:|..:|.            .|.||.
  Rat  1860 WLKDDQPVNTAPGNLRIQSSGRVLQIAKALLEDAGR---YTCVATNAAGEAHQHTQLHVHEPPSL 1921

  Fly  1018 SQLGAALSKAM 1028
            ...|..|::::
  Rat  1922 DDGGKMLNESV 1932

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
otkNP_523705.2 I-set 26..115 CDD:254352 24/90 (27%)
Ig 31..115 CDD:299845 24/85 (28%)
IGc2 133..195 CDD:197706 24/64 (38%)
Ig 268..373 CDD:299845 32/172 (19%)
Ig 395..460 CDD:143165 20/66 (30%)
I-set 468..559 CDD:254352 31/98 (32%)
IGc2 484..549 CDD:197706 21/69 (30%)
PTK_CCK4 686..1026 CDD:133178 68/391 (17%)
STYKc 692..1020 CDD:214568 66/379 (17%)
Hmcn1NP_001258221.1 VWA_2 42..212 CDD:290253
I-set 520..608 CDD:254352
ig 524..606 CDD:278476
I-set 612..696 CDD:254352
Ig 626..696 CDD:299845
I-set 702..789 CDD:254352
Ig 716..789 CDD:299845
Ig 792..884 CDD:299845 0/1 (0%)
IG_like 799..884 CDD:214653 0/1 (0%)
I-set 890..977 CDD:254352 26/100 (26%)
IGc2 903..967 CDD:197706 20/66 (30%)
Ig 980..1071 CDD:299845 32/95 (34%)
IG 994..1068 CDD:214652 28/78 (36%)
I-set 1085..1167 CDD:254352 9/81 (11%)
Ig 1086..1167 CDD:299845 9/80 (11%)
I-set 1171..1258 CDD:254352 11/86 (13%)
Ig 1188..1255 CDD:143165 7/66 (11%)
Ig 1261..1357 CDD:299845 27/126 (21%)
I-set 1267..1355 CDD:254352 26/118 (22%)
I-set 1368..1448 CDD:254352 21/80 (26%)
Ig 1380..1448 CDD:299845 19/68 (28%)
IG 1460..1541 CDD:214652 27/87 (31%)
IGc2 1470..1532 CDD:197706 21/68 (31%)
IG_like 1557..1633 CDD:214653 19/104 (18%)
Ig 1565..1632 CDD:143165 18/95 (19%)
I-set 1645..1729 CDD:254352 20/105 (19%)
Ig 1648..1725 CDD:299845 19/98 (19%)
I-set 1752..1822 CDD:254352 15/69 (22%)
Ig 1754..1815 CDD:299845 12/60 (20%)
IG 1834..1915 CDD:214652 17/112 (15%)
IGc2 1843..1905 CDD:197706 15/88 (17%)
IG_like 1929..2008 CDD:214653 0/4 (0%)
IGc2 1935..1998 CDD:197706
I-set 2012..2100 CDD:254352
Ig 2021..2092 CDD:299845
I-set 2111..2191 CDD:254352
IGc2 2119..2181 CDD:197706
I-set 2203..2286 CDD:254352
IGc2 2210..2276 CDD:197706
Ig 2299..2380 CDD:299845
IG_like 2300..2380 CDD:214653
I-set 2392..2474 CDD:254352
IGc2 2400..2464 CDD:197706
I-set 2478..2567 CDD:254352
IGc2 2493..2557 CDD:197706
I-set 2582..2663 CDD:254352
IGc2 2594..2653 CDD:197706
I-set 2681..2762 CDD:254352
Ig 2688..2762 CDD:299845
IG_like 2789..2865 CDD:214653
IGc2 2791..2855 CDD:197706
I-set 2879..2960 CDD:254352
Ig 2879..2950 CDD:299845
IG 2972..3052 CDD:214652
IGc2 2982..3042 CDD:197706
IG 3069..3147 CDD:214652
IGc2 3073..3137 CDD:197706
IG 3150..3241 CDD:214652
Ig 3150..3241 CDD:299845
Ig 3244..3338 CDD:299845
I-set 3252..3336 CDD:254352
I-set 3354..3430 CDD:254352
IGc2 3357..3420 CDD:197706
Ig 3433..3523 CDD:299845
IG_like 3443..3523 CDD:214653
IG_like 3535..3616 CDD:214653
IGc2 3543..3606 CDD:197706
I-set 3629..3709 CDD:254352
IGc2 3636..3699 CDD:197706
I-set 3713..3800 CDD:254352
Ig 3719..3795 CDD:299845
Ig 3823..3889 CDD:143165
I-set 3897..3984 CDD:254352
IGc2 3913..3974 CDD:197706
Ig 3993..4066 CDD:299845
IG_like 3994..4075 CDD:214653
IG_like 4085..4165 CDD:214653
IGc2 4092..4155 CDD:197706
Ig 4168..4258 CDD:299845
IG 4177..4256 CDD:214652
I-set 4260..4345 CDD:254352
IGc2 4274..4335 CDD:197706
IG_like 4356..4435 CDD:214653
IGc2 4364..4426 CDD:197706
I-set 4440..4526 CDD:254352
Ig 4440..4521 CDD:299845
TSP1 4533..4584 CDD:214559
TSP1 4589..4641 CDD:214559
TSP1 4646..4698 CDD:214559
TSP1 4703..4755 CDD:214559
TSP1 4760..4812 CDD:214559
TSP1 4817..4869 CDD:214559
G2F 4868..5092 CDD:214774
EGF_CA 5107..5146 CDD:214542
EGF_CA 5147..5190 CDD:284955
EGF_CA 5192..5229 CDD:214542
EGF_CA 5230..5263 CDD:238011
EGF_CA 5272..5313 CDD:284955
EGF_CA 5315..5354 CDD:214542
EGF_CA 5432..5471 CDD:214542
EGF_CA 5472..5508 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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