DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment otk and Vwa7

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_613048.1	Gene:	Vwa7 / 27762	MGIID:	1306798	Length:	891	Species:	Mus musculus

Alignment Length:	374	Identity:	78/374 - (20%)
Similarity:	120/374 - (32%)	Gaps:	122/374 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 SGKDALLREDARLVLHKQNGTLSFASIIASDAGQYQCQLQLEAHAPINSSPGILEVIEQLKFVPQ 382
            |.|||||......:..::...::|  ::..|..:...:.:.||.:|:...|  .|.|.:......
Mouse   420 SPKDALLTNRVESLTRERRCRVTF--LVTEDPSRTGGRRRREALSPLRFEP--YEAIARASGGEV 480

  Fly   383 PTSKNLELDAVVAKVHCKAQGTPT----PQVQWVRDGENTTLPDHVEVDANGTLIFRNVNSEHRG 443
            ..:|:..:..|.|.|.....|..|    |.|  ...||    |....||:    :...|.....|
Mouse   481 IFTKDQYIQDVAAIVGESMAGLVTLPLDPPV--FTPGE----PCVFSVDS----LLWQVTVRMHG 535

  Fly   444 NYTCL-----ATNSQGQINATVAINVVVTPKFSVPPVGPIETSEQ------------GTVVMHCQ 491
            :.:..     |..|||             |:..:.|:|......|            ||..:...
Mouse   536 DISSFWIKSPAGVSQG-------------PEEGIGPLGHTRRFGQFWTVTMTDPPRTGTWEIQVA 587

  Fly   492 AIGDPKPTIQWDKDLKYLSENNTDRERFRFLENGTLEIRNVQVED---EGSYGCTIGNSAGLKRE 553
            |.|.|:..:|....|.:|         |.|         .:.|||   .|.|..| ...|||:
Mouse   588 AAGTPRVRVQAQTSLDFL---------FHF---------GISVEDGPHPGLYPLT-QPVAGLQ-- 631

  Fly   554 DVQLVVKTTGDGFAPEESGGDGFLVTRAVLITMTVALAYIVLVVGLMLWCRYRRQARKARLNDLS 618
             .||:|:.||             |.:|..|:......:::||          ||.....:|..:|
Mouse   632 -TQLLVEVTG-------------LTSRQKLVGGQPQFSHVVL----------RRVPEGTQLGRVS 672

  Fly   619 TKEAGG-----------------DQP---DVAGNGKGSEQ------EPC 641
            .:..|.                 ..|   ::.|.|.|.|.      :||
Mouse   673 LEPVGPPVRGLLAASLPPTLLSVSSPFSLELVGQGGGGESLRRTAPQPC 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352
		Ig	31..115	CDD:299845
		IGc2	133..195	CDD:197706
		Ig	268..373	CDD:299845	12/54 (22%)
		Ig	395..460	CDD:143165	17/73 (23%)
		I-set	468..559	CDD:254352	25/105 (24%)
		IGc2	484..549	CDD:197706	16/67 (24%)
		PTK_CCK4	686..1026	CDD:133178
		STYKc	692..1020	CDD:214568
Vwa7	NP_613048.1	Het-C	<164..>191	CDD:369266
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	238..273
		VWA_2	319..419	CDD:379234
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900