Protein Alignment otk and NPTN

DIOPT Version :10

• Sequence 1: NP_523705.2
• Gene: otk / 36283
• FlyBaseID: FBgn0004839
• Length: 1033
• Species: Drosophila melanogaster
• Sequence 2: NP_036560.1
• Gene: NPTN / 27020
• HGNCID: 17867
• Length: 398
• Species: Homo sapiens
• Alignment Length: 428
• Identity: 96/428 - (22%)
• Similarity: 161/428 - (37%)
• Gaps: 144/428 - (33%)

  Fly     7 SICGLVMALMMASVL-----ASSSRFQRVPQSQSVVENESVKFECESTDS--------YSELH-- 56
            |...|.:.|:..|:|     |.::.|.:.|.|::.:..::.:..|:...|        |:|::
Human     8 SALALSLLLVSGSLLPGPGAAQNAGFVKSPMSETKLTGDAFELYCDVVGSPTPEIQWWYAEVNRA 72

  Fly    57 --YDWLHNGHRIAYDKRV---HQIGSNLHIEAVRRT----EDVGNYVCIATN--LASGAREASP- 109
              :..|.:|.|   .:||   ...||| .:..:|.|    ||.|.|.|.|:|  ..:..|: :|
Human    73 ESFRQLWDGAR---KRRVTVNTAYGSN-GVSVLRITRLTLEDSGTYECRASNDPKRNDLRQ-NPS 132

  Fly   110 ------PAKLSVI----YLESASVQLLGSNRNELLLKCHVEGASGDLEPLEIEWYRNSEKLS-TW 163
                  .|.:||:    .:.|..|.:..|....:.|:|::..:|..|  ....|.:|..:|| |.
Human   133 ITWIRAQATISVLQKPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTL--TYSYWTKNGVELSATR 195

  Fly   164 KNVQLDQHRLIIRQPGSEDDGLYRCTASNAAGRVMSKQGYVYQSSVKCLPRLPRRKNEKMMESWD 228
            ||....::|  |.:|.:||.|.|.|.             |.:.|:.|
Human   196 KNASNMEYR--INKPRAEDSGEYHCV-------------YHFVSAPK------------------ 227

  Fly   229 KQTFLCRGKRGGAAGLEALPAAPEDLRIVQGPIGQSIIKEGEPTALTCL---YELPDELKNQRIQ 290
                       ..|.:| :.|||:    :.|........||:...:.|.   |..||.:
Human   228 -----------ANATIE-VKAAPD----ITGHKRSENKNEGQDATMYCKSVGYPHPDWI------ 270

  Fly   291 LRWRK--DGKLLRQVELGGSAPIPGHSFDSGKDALLREDARLVLHKQNGT-LSFASI-IASDAGQ 351
              |||  :|..:..|...|..                    .:::|:|.| |:..:: |..|.|:
Human   271 --WRKKENGMPMDIVNTSGRF--------------------FIINKENYTELNIVNLQITEDPGE 313

  Fly   352 YQCQ-------------LQLEAH-APINSSPGIL-EVI 374
            |:|.             |::.:| ||:....||| |:|
Human   314 YECNATNAIGSASVVTVLRVRSHLAPLWPFLGILAEII 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	Ig_3	31..99	CDD:464046	22/86 (26%)
		Ig strand B	133..137	CDD:409353	1/3 (33%)
		Ig	<135..197	CDD:472250	19/62 (31%)
		Ig strand C	150..154	CDD:409353	0/3 (0%)
		Ig strand E	171..175	CDD:409353	1/3 (33%)
		Ig strand F	185..190	CDD:409353	2/4 (50%)
		Ig	265..360	CDD:472250	22/114 (19%)
		Ig strand B	272..276	CDD:409571	0/3 (0%)
		Ig strand C	290..294	CDD:409571	0/3 (0%)
		Ig strand E	337..341	CDD:409571	2/4 (50%)
		Ig strand F	351..356	CDD:409571	2/17 (12%)
		Ig	395..460	CDD:409353
		Ig strand B	395..399	CDD:409353
		Ig strand C	408..412	CDD:409353
		Ig strand E	430..434	CDD:409353
		Ig strand F	444..449	CDD:409353
		Ig strand G	457..460	CDD:409353
		I-set	468..559	CDD:400151
		Ig strand B	486..490	CDD:409570
		Ig strand C	499..503	CDD:409570
		Ig strand E	525..529	CDD:409570
		Ig strand F	539..544	CDD:409570
		Ig strand G	552..555	CDD:409570
		PTK_CCK4	686..1026	CDD:133178
NPTN	NP_036560.1	Ig	31..146	CDD:472250	29/119 (24%)
		Ig strand B	48..52	CDD:409353	0/3 (0%)
		Ig strand C	61..65	CDD:409353	0/3 (0%)
		Ig strand E	99..103	CDD:409353	0/3 (0%)
		Ig strand F	113..118	CDD:409353	2/4 (50%)
		Ig strand G	137..140	CDD:409353	0/2 (0%)
		Narpin, mediates binding with FGFR1 and has antidepressant-like activity. /evidence=ECO:0000250	149..161		2/11 (18%)
		Ig	168..219	CDD:472250	18/54 (33%)
		Ig strand C	180..185	CDD:409353	0/4 (0%)
		Ig strand E	201..205	CDD:409353	1/5 (20%)
		Ig strand F	215..219	CDD:409353	1/3 (33%)
		Ig	250..333	CDD:472250	22/110 (20%)
		Ig strand B	255..259	CDD:409570	0/3 (0%)
		Ig strand C	268..274	CDD:409570	3/13 (23%)
		Ig strand E	297..302	CDD:409570	2/4 (50%)
		Ig strand F	313..318	CDD:409570	2/4 (50%)
		Ig strand G	326..329	CDD:409570	0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	365..398