DRSC/TRiP Functional Genomics Resources

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Protein Alignment otk and ttn-1

DIOPT Version :9

Sequence 1:NP_523705.2 Gene:otk / 36283 FlyBaseID:FBgn0004839 Length:1033 Species:Drosophila melanogaster
Sequence 2:NP_001346715.1 Gene:ttn-1 / 266969 WormBaseID:WBGene00006436 Length:15188 Species:Caenorhabditis elegans


Alignment Length:1247 Identity:243/1247 - (19%)
Similarity:400/1247 - (32%) Gaps:436/1247 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 TARMISICGLVMALMMASVLASSSRFQRVPQSQSVVENES-------VKFECESTDSYSELHY-- 57
            |.|..:..|.:|.....||.|...:.::...|.:|:|.:.       |..| |..|.....|:  
 Worm 12967 TCRATNDLGSIMTHAKLSVKADEKKKKKSKTSPAVIEKKKDRKTSKVVVIE-EMIDMPPNFHHLL 13030

  Fly    58 -------------------------DWLHNGHRIAYDK----RVHQIGS-NLHIEAVRRTEDVGN 92
                                     ||.|||..|:.:.    |.|..|. .|||.:|..| |.|.
 Worm 13031 QDDEAKIGEPKILVVTNTTLPEPTVDWYHNGEHISINDSNYLRKHDKGRYELHILSVDST-DEGK 13094

  Fly    93 YVCIATNLASGAREASPPAKLSVIYLESASVQLLGSNRNELLLKCHVEGASGDLEPL-------- 149
            :..:..| |.|  |....|||:|:..:.......|...::  :||    :..|:..|        
 Worm 13095 WKAVGKN-AFG--ECESEAKLTVVIPDGQYAPSFGKQLSD--VKC----SESDILKLEVNIQANP 13150

  Fly   150 --EIEWYRNSEKL--STWKNVQLD----QHRLIIRQPGSEDDGLYRCTASNAAGRVMSKQGYVYQ 206
              ||.|:||..::  |....:|.|    .:.|.|....:||.|.|:|.|.|..|:.         
 Worm 13151 APEINWFRNESEIEHSQHHRLQFDDGSGNYSLTIIDAYAEDSGEYKCVAKNKIGKA--------- 13206

  Fly   207 SSVKCLPRLPRRKNEKMMESWDKQTFLCRGKRGGAAGLEALPAAPEDLRIVQGPIGQSIIKEGEP 271
            .:|.|:         ::.|...|::....|.:.....:: ||...|             :.:|..
 Worm 13207 HTVCCV---------RIEELLSKRSKKIDGSKAPRFRMQ-LPTPRE-------------VPQGAD 13248

  Fly   272 TALTCLYELPDELKNQRIQLRWRKDGKLLRQVELGGSAPIPGHSFDSGKDALLREDARLVLHKQN 336
            ..|.|...     ......::|.||.|           ||     |.....:..|:....||   
 Worm 13249 LTLVCSVS-----GTPHPNIKWTKDDK-----------PI-----DMSNKQVRHENGVCTLH--- 13289

  Fly   337 GTLSFASIIAS---DAGQYQCQLQLEAHAPINSSPGILEVIEQL-------KFV-PQPTSKNLEL 390
                   ||.:   |.|:|.|:.: ..|. :..|..::|:.|.:       ||: |.......|.
 Worm 13290 -------IIGARDDDQGRYVCEAE-NIHG-VAQSFSVVEIKEAVDKDHVRPKFLEPLVNCSTCEG 13345

  Fly   391 DAVVAKVHCKAQGTPTPQVQWVRDG-----ENTTLPDHVEVDANGT--LIFRNVNSEHRGNYTCL 448
            :.:|  :.|...|.|.|.:.|.:||     ||..|.   ..|..|.  |...||.....|.|||.
 Worm 13346 NEMV--LECCVTGKPIPTITWYKDGLKLIIENRMLQ---YTDRKGVSRLNIMNVVMNDDGEYTCE 13405

  Fly   449 ATNSQGQINATVAINVV--------VTP-----------------KFSVPPV-----GPIETSEQ 483
            |.||.|:......:.||        :||                 :...|||     .....:|.
 Worm 13406 AVNSLGKDFTHCTVKVVDMGLSKTRLTPVRSRSRSRSRSPSVVGGEIQRPPVVTRPLADATVTEG 13470

  Fly   484 GTVVMHCQAIGDPKPTIQWDKDLKYLSENNTDRERFRFLENGT---LEIRNVQVEDEGSYGCTIG 545
            ...::..:..|.|.|||:|..|.|.::|:.|.|..|    :|.   |:|.....|..|.|.|.:.
 Worm 13471 NRELLEVEVDGFPTPTIEWYHDGKLVAESRTLRTYF----DGRVAFLKIYEAHEEHNGQYVCKVS 13531

  Fly   546 NSAGLKREDVQLVVKTTGDGFAPEESGGDGFLVTRAVLITMTVALAYIVLVVGLMLWCRYRRQAR 610
            |..|.                          :.|||:::......|..|..:...:         
 Worm 13532 NKLGA--------------------------VETRAIVVVEAPDAAEHVTQMPTFV--------- 13561

  Fly   611 KARLNDLSTKEAGGDQPDVAGNGKGSEQEPCLSK--QHNGHSKSRSKSSGDAQKSDDTACSQQSR 673
             .:|.|:..|.||    :.|.....|...|....  .|||.:..::||:...:..||      :.
 Worm 13562 -KKLQDVVLKTAG----ETATFTCQSYANPAAQVVWLHNGKALQQTKSNYKTRLFDD------NT 13615

  Fly   674 ASKKSAHIYEQLALPRSGLSELIQIGRGEFGDV----------------------FVGKLK---- 712
            |:....::.::|.      .....:...:||||                      |:.:||    
 Worm 13616 ATLVIENVTDELC------GTYTAVANNQFGDVHTSAQLTISGSEAKKIAASLPYFIIELKPKIN 13674

  Fly   713 ----------ATLVTSPSDK-----------DADTEKQHSNSEN------GSGGSGSGSTTLSTL 750
                      |.|..||..:           ::|..:...:..|      ..|....|:.|::..
 Worm 13675 VVEGATLSIQADLNGSPIPEVVWLKDNSELVESDRIQMKCDGVNYQLLVRDVGLEDEGTYTITAE 13739

  Fly   751 NEKRR-------SKTSMDDIEEIKEEEQDQHNQSGLE---QLVLVKALNKVKDEQACQEF----- 800
            |||.:       |.|...:::|.||:::.:....|.:   :..|.:.....|.||....|     
 Worm 13740 NEKGKIRQNTEVSVTKSKEVKEKKEKKKVEKKDEGKKKPGRPGLPRPSGASKTEQVTMAFDAPSE 13804

  Fly   801 ---------RR---QLDLLRAISHKGV-VRLFGLCREKDPHYMV-----------------LEYT 835
                     ||   |.:.:...|.|.: :.:.||....:..:.|                 |:..
 Worm 13805 GPADSYEVERRCPDQREWVSCGSTKSLELEIKGLTPNTEYIFRVAGKNKQGLGEWSEMTSTLKTA 13869

  Fly   836 DWGDLKQFLLATAGKV--------NTATAGSSSPPP---------------------LTTSQVLA 871
            ..|...||.::...|:        ..|...|.:|.|                     .:||.:|.
 Worm 13870 SVGQAPQFTISPQSKIIANRDDEFEIAVEFSGTPTPSVKWYKENLQIVPDEKIDVATTSTSSILN 13934

  Fly   872 VAYQIARGMDAIYRARFTHRDLATRNCVISSEFIVKVSYPALCKDKYSREYHKHRNTLLPIRWLA 936
            :..|...|               |.||:|.:| :.:.|  |.|:                     
 Worm 13935 LKSQEENG---------------TFNCLIENE-LGQAS--ASCQ--------------------- 13960

  Fly   937 PECIQEDEYTTKSDIFAYGVVVWELFNQATKLPHEELTNEQVVQRSQAGSLEWSVAEATPDSLRE 1001
                                  ..:||:...|   :.|.:..::|:...:|:.::...:..:.::
 Worm 13961 ----------------------VTIFNKPASL---QSTPDHSLERNLVPTLQKALNNESAQAGQQ 14000

  Fly  1002 ILLSCWVSNPKE 1013
            |:|:|.:|:..|
 Worm 14001 IMLTCRISSRSE 14012

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
otkNP_523705.2 I-set 26..115 CDD:254352 31/127 (24%)
Ig 31..115 CDD:299845 31/122 (25%)
IGc2 133..195 CDD:197706 21/77 (27%)
Ig 268..373 CDD:299845 21/107 (20%)
Ig 395..460 CDD:143165 23/71 (32%)
I-set 468..559 CDD:254352 26/115 (23%)
IGc2 484..549 CDD:197706 20/67 (30%)
PTK_CCK4 686..1026 CDD:133178 71/455 (16%)
STYKc 692..1020 CDD:214568 71/449 (16%)
ttn-1NP_001346715.1 IG 105..177 CDD:214652
I-set 205..285 CDD:333254
I-set 406..493 CDD:333254
I-set 821..914 CDD:333254
Ig 962..1032 CDD:319273
I-set 1135..1215 CDD:333254
I-set 1679..1767 CDD:254352
Ig 1789..>1845 CDD:319273
Atrophin-1 <1957..2285 CDD:331285
I-set 2381..2468 CDD:333254
I-set 2489..2578 CDD:333254
I-set 2631..2717 CDD:333254
I-set 2732..2815 CDD:333254
Ig 2848..2909 CDD:319273
I-set 2924..3007 CDD:333254
RNase_E_G <3161..3303 CDD:331378
RNase_E_G <3356..3556 CDD:331378
RNase_E_G <3506..3673 CDD:331378
RNase_E_G <3595..3803 CDD:331378
RNase_E_G <3722..3912 CDD:331378
RNase_E_G <3875..4073 CDD:331378
FtsK <4014..>4556 CDD:332908
RNase_E_G <4346..4567 CDD:331378
RNase_E_G <4525..4723 CDD:331378
RNase_E_G <4746..4936 CDD:331378
RNase_E_G <4858..5044 CDD:331378
FtsK <4960..>5541 CDD:332908
Neuromodulin_N <5525..6250 CDD:331332
Neuromodulin_N <6198..6681 CDD:331332
V-ATPase_G_2 <6559..>6683 CDD:330366
I-set 7448..7535 CDD:333254
FN3 7540..7630 CDD:238020
MDN1 <7687..8197 CDD:331582
Neuromodulin_N <7944..8780 CDD:331332
Ig 8886..>8935 CDD:325142
FN3 9052..9142 CDD:238020
Neuromodulin_N <9210..9875 CDD:331332
Neuromodulin_N <9583..10392 CDD:331332
IG_like 10597..>10662 CDD:214653
Ig 10711..10773 CDD:325142
FN3 10777..10870 CDD:238020
FN3 10883..10958 CDD:238020
FN3 10984..11070 CDD:238020
I-set 11077..11165 CDD:333254
IG 11179..11259 CDD:214652
I-set 11264..11350 CDD:333254
I-set 11368..11446 CDD:333254
FN3 11450..11543 CDD:238020
FN3 11565..11645 CDD:238020
I-set 11823..11903 CDD:333254
I-set 11918..11996 CDD:333254
FN3 12006..12097 CDD:238020
FN3 12131..12217 CDD:238020
I-set 12225..12313 CDD:333254
Ig 12337..12411 CDD:325142
FN3 12415..12503 CDD:238020
PKc_like 12566..12815 CDD:328722
I-set 12894..12985 CDD:254352 4/17 (24%)
I-set 13024..13114 CDD:333254 24/93 (26%)
I-set 13123..13206 CDD:254352 23/88 (26%)
Ig 13249..13314 CDD:319273 19/97 (20%)
I-set 13331..13421 CDD:254352 28/94 (30%)
I-set 13456..13545 CDD:254352 27/118 (23%)
I-set 13558..13650 CDD:254352 21/117 (18%)
I-set 13663..13753 CDD:254352 15/89 (17%)
FN3 13778..13864 CDD:238020 13/85 (15%)
Ig 13893..13963 CDD:325142 17/130 (13%)
I-set 13984..14074 CDD:333254 6/29 (21%)
I-set 14083..14168 CDD:254352
Ig_3 14195..14275 CDD:316449
Ig_3 14302..14384 CDD:316449
I-set 14408..14498 CDD:333254
I-set 14634..14724 CDD:333254
IG_like 14754..14838 CDD:214653
I-set 14854..14943 CDD:333254
I-set 14969..15044 CDD:254352
Ig_3 15054..15132 CDD:316449
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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