Protein Alignment otk and Ror1

DIOPT Version :10

• Sequence 1: NP_523705.2
• Gene: otk / 36283
• FlyBaseID: FBgn0004839
• Length: 1033
• Species: Drosophila melanogaster
• Sequence 2: NP_038873.2
• Gene: Ror1 / 26563
• MGIID: 1347520
• Length: 937
• Species: Mus musculus
• Alignment Length: 783
• Identity: 170/783 - (21%)
• Similarity: 300/783 - (38%)
• Gaps: 133/783 - (16%)

  Fly   334 KQNGT-------LSFASIIASDAGQYQCQLQLEAHAPINSSPGILEVIEQLKF--VPQPTSKNLE 389
            ::.||       |:...:.|..|...:.:|.:.|.....||......|::..:  :.:|.:....
Mouse     5 RRRGTRPPPLALLAALLLAARGADAQETELSVSAELVPTSSWNTSSEIDKGSYLTLDEPMNNITT 69

  Fly   390 LDAVVAKVHCKAQGTPTPQVQWVR-DGENTTLPDHVEVDA---NGTLIFRNVNSEHRGNYTCLAT 450
            .....|::|||..|.|.|.::|.: |......|..:...|   ...|..||:::...|.:.|:||
Mouse    70 SLGQTAELHCKVSGNPPPSIRWFKNDAPVVQEPRRISFRATNYGSRLRIRNLDTTDTGYFQCVAT 134

  Fly   451 NSQGQINATVAINVVVTPKFSVPPVGPIETSEQGTVVMHCQAIGDPKPTIQWDKDLKYLSENNTD 515
            |.:..::.|..:.|    ||..||.....:|::......||    |...|..
Mouse   135 NGKKVVSTTGVLFV----KFGPPPTASPGSSDEYEEDGFCQ----PYRGIAC------------- 178

  Fly   516 RERFRFLENGTLEIRNVQVEDEGSYGCT-----IGNSAGLKREDVQLVVKT-----------TGD 564
               .||:.|.|:.:.::.::.|.....|     ||.|:.|..:..|..:.:           |..
Mouse   179 ---ARFIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSS 240

  Fly   565 GFAPEESGGDGFLVTRAVLITMTVALAYIVLVVGLMLWCRYRRQARKARLNDLSTKEAGGDQPDV 629
            ...|.:...|...|...||    ....||......|:..|    .:.....||...|:    |:.
Mouse   241 VPKPRDLCRDECEVLENVL----CQTEYIFARSNPMILMR----LKLPNCEDLPQPES----PEA 293

  Fly   630 AGNGK-GSEQEPCLSKQHNGHSKSRSKSSGDAQKSDDTACSQQSRASKKSAHIYEQLALP--RSG 691
            |...: |......::|.|..::.:.....|....:......|...:.....|.:..|..|  ..|
Mouse   294 ANCIRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHSFTALRFPELNGG 358

  Fly   692 LSELIQIGRGEFGD---VFVGKLKATLVTSPSDKDADTEKQHS---------------------- 731
            .|.....|..:...   ......|:.|...|:....|:::::.
Mouse   359 HSYCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIAFLFF 423

  Fly   732 ------NSENGSG-----------GSGSGSTTLSTLNEKRRSK----TSMDDIEEIKEEEQDQHN 775
                  |::..|.           |.....:.|:....|.::|    :::..:||:.|....:..
Mouse   424 FICVCRNNQKSSSPPVQRQPKPVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECTFGKIY 488

  Fly   776 QSGL-------EQLVLVKALNKVKDEQACQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLE 833
            :..|       .|||.:|.|....:.|...||:::..|:..:.|..:|.|.|...::.|..|:.|
Mouse   489 KGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFE 553

  Fly   834 YTDWGDLKQFLLATAGKVNTATAGSSS------PPPLTTSQVLAVAYQIARGMDAIYRARFTHRD 892
            |.:.|||.:||:..:..   :..|.||      ...|.....|.:|.|||.||:.:....|.|:|
Mouse   554 YMNQGDLHEFLIMRSPH---SDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKD 615

  Fly   893 LATRNCVISSEFIVKVSYPALCKDKYSREYHK-HRNTLLPIRWLAPECIQEDEYTTKSDIFAYGV 956
            ||.||.:|..:..||:|...|.::.||.:|:: ...:.|||||:.||.|...::::.|||:::||
Mouse   616 LAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSSLPIRWMPPEAIMYGKFSSDSDIWSFGV 680

  Fly   957 VVWELFNQATKLPHEELTNEQVVQRSQAGSLEWSVAEATPDSLREILLSCWVSNPKERPSFSQLG 1021
            |:||:|:...: |:...:|::|::..:...| ...:|..|..:..::..||...|..||.|..:.
Mouse   681 VLWEIFSFGLQ-PYYGFSNQEVIEMVRKRQL-LPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIH 743

  Fly  1022 AAL 1024
            ..|
Mouse   744 VRL 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	Ig_3	31..99	CDD:464046
		Ig strand B	133..137	CDD:409353
		Ig	<135..197	CDD:472250
		Ig strand C	150..154	CDD:409353
		Ig strand E	171..175	CDD:409353
		Ig strand F	185..190	CDD:409353
		Ig	265..360	CDD:472250	6/32 (19%)
		Ig strand B	272..276	CDD:409571
		Ig strand C	290..294	CDD:409571
		Ig strand E	337..341	CDD:409571	3/10 (30%)
		Ig strand F	351..356	CDD:409571	0/4 (0%)
		Ig	395..460	CDD:409353	19/68 (28%)
		Ig strand B	395..399	CDD:409353	1/3 (33%)
		Ig strand C	408..412	CDD:409353	0/3 (0%)
		Ig strand E	430..434	CDD:409353	1/3 (33%)
		Ig strand F	444..449	CDD:409353	1/4 (25%)
		Ig strand G	457..460	CDD:409353	0/2 (0%)
		I-set	468..559	CDD:400151	20/95 (21%)
		Ig strand B	486..490	CDD:409570	0/3 (0%)
		Ig strand C	499..503	CDD:409570	1/3 (33%)
		Ig strand E	525..529	CDD:409570	1/3 (33%)
		Ig strand F	539..544	CDD:409570	1/9 (11%)
		Ig strand G	552..555	CDD:409570	0/2 (0%)
		PTK_CCK4	686..1026	CDD:133178	96/401 (24%)
Ror1	NP_038873.2	I-set	63..148	CDD:400151	21/84 (25%)
		Ig strand B	75..79	CDD:409353	1/3 (33%)
		Ig strand C	88..92	CDD:409353	0/3 (0%)
		Ig strand E	114..118	CDD:409353	1/3 (33%)
		Ig strand F	128..133	CDD:409353	1/4 (25%)
		Ig strand G	139..142	CDD:409353	0/2 (0%)
		CRD_TK_ROR1	166..307	CDD:143576	31/172 (18%)
		KR	311..393	CDD:214527	12/81 (15%)
		PTKc_Ror1	467..749	CDD:270672	82/285 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	753..778
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	840..890
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	916..937