DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otk and IL1RAPL2

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_059112.1	Gene:	IL1RAPL2 / 26280	HGNCID:	5997	Length:	686	Species:	Homo sapiens

Alignment Length:	821	Identity:	150/821 - (18%)
Similarity:	259/821 - (31%)	Gaps:	310/821 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 PPAKLSVIYLESASVQL-LGSNRNELLLKCHVEGA---SGDL--------EPLEIE--------- 152
            ||..|:::.....|..| :.|.||.      |:|.   |.||        ||:.::
Human     3 PPFLLALVVCSVVSTNLKMVSKRNS------VDGCIDWSVDLKTYMALAGEPVRVKCALFYSYIR 61

  Fly   153 --------------WYRNS---EKLSTWKNVQL--DQHRLIIRQPGSEDDGLYRCTASNAAGRVM 198
                          ||:|.   |:...:..|::  ::..:......::|.|.|.|
Human    62 TNYSTAQSTGLRLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTC---------- 116

  Fly   199 SKQGYVYQSSVKCLPRLPRRKNEKMMESWDKQTFLCRGKRGGAAGLEALPAAPEDLRIVQGPIGQ 263
                 |.::|..|:      |....:...:.::.||...|               :|.::   ..
Human   117 -----VLRNSTYCM------KVSMSLTVAENESGLCYNSR---------------IRYLE---KS 152

  Fly   264 SIIKEGEPTALTCLYELPD----ELKNQRIQLRWRKD--GKLLRQVELGGSAPIPGHSFDSGKDA 322
            .:.|..|   ::|    ||    :..:|...:.|.|:  .|:.|.:
Human   153 EVTKRKE---ISC----PDMDDFKKSDQEPDVVWYKECKPKMWRSI------------------- 191

  Fly   323 LLREDARLVLHKQNGTLSFASIIASDAGQYQCQLQLEAHA----------------------PIN 365
                    ::.|.|..| ...:...|.|.|.|:|:.|...                      |:.
Human   192 --------IIQKGNALL-IQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPME 247

  Fly   366 SSPGILEVIEQLKFVPQPTSKNLELDAVVAKVHCKA----QGTPTPQVQW-------------VR 413
            :.|.:::|  ||       .|.|       .:.|||    .|...|.:.|             :|
Human   248 NQPSVIDV--QL-------GKPL-------NIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIR 296

  Fly   414 DGENTTLPDHV-EVDANGTLIFRNVNSEHRGNYTCLATNSQGQINATVAIN-------------- 463
            :||...|.:|: |.:....|||.:|......||||...|..|:.:|:|.:.
Human   297 EGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKKDLIYKIELAGGL 361

  Fly   464 ----------VVVTPKFSVPPV-------GPIETSEQGTVVMHCQAIGDPKPTIQWDKDLKY--- 508
                      ||:...:::..:       |..||::            |.|   ::|..|.|
Human   362 GAIFLLLVLLVVIYKCYNIELMLFYRQHFGADETND------------DNK---EYDAYLSYTKV 411

  Fly   509 ----LSENNTDRERFRFLENGTLEIRNVQVEDEGSYGCTIGN----SAGLKREDV--------QL 557
                |..:|.:.|:|      .||:....:|....|...|..    .:|...||:        :|
Human   412 DQDTLDCDNPEEEQF------ALEVLPDVLEKHYGYKLFIPERDLIPSGTYMEDLTRYVEQSRRL 470

  Fly   558 VVKTTGD-----GFA--PEESGGDGFLVT---RAVLITMT-----------VALAYIVLVVGLML 601
            ::..|.|     |::  ..||.....||:   :.:||..|           .:|...:.::.|:.
Human   471 IIVLTPDYILRRGWSIFELESRLHNMLVSGEIKVILIECTELKGKVNCQEVESLKRSIKLLSLIK 535

  Fly   602 WCRYRRQARKARLNDLSTKEAGGDQP-------------DVAGNGKGSEQEPCLSKQHNGHSKSR 653
            |    :.::.::||....|....:.|             |.|..|...|.:|..|......|.:.
Human   536 W----KGSKSSKLNSKFWKHLVYEMPIKKKEMLPRCHVLDSAEQGLFGELQPIPSIAMTSTSATL 596

  Fly   654 SKSSGDAQKSDDTACSQQSRASKKSAHIYEQLALPRSGLSELIQIGRGEFGDVFVGKLKATLVTS 718
            ..|..|..:...:...|.....:...|......||...|.     ....:.::.:..|...|..:
Human   597 VSSQADLPEFHPSDSMQIRHCCRGYKHEIPATTLPVPSLG-----NHHTYCNLPLTLLNGQLPLN 656

  Fly   719 PSDKDADTEKQHSNSENGSGGSGSGSTTLSTLNEKRRSKTS 759
            .:.|  ||::.|.||            :|..|:.|..|.||
Human   657 NTLK--DTQEFHRNS------------SLLPLSSKELSFTS 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352	3/5 (60%)
		Ig	31..115	CDD:299845	3/5 (60%)
		IGc2	133..195	CDD:197706	16/100 (16%)
		Ig	268..373	CDD:299845	20/132 (15%)
		Ig	395..460	CDD:143165	23/82 (28%)
		I-set	468..559	CDD:254352	21/116 (18%)
		IGc2	484..549	CDD:197706	14/75 (19%)
		PTK_CCK4	686..1026	CDD:133178	17/74 (23%)
		STYKc	692..1020	CDD:214568	15/68 (22%)
IL1RAPL2	NP_059112.1	Ig	32..133	CDD:325142	18/121 (15%)
		Ig2_IL1R_like	146..237	CDD:319309	20/128 (16%)
		IG_like	250..347	CDD:214653	30/112 (27%)
		TIR	402..563	CDD:307630	33/170 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910