DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment otk and Il1r1

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_037255.3	Gene:	Il1r1 / 25663	RGDID:	2892	Length:	590	Species:	Rattus norvegicus

Alignment Length:	373	Identity:	85/373 - (22%)
Similarity:	137/373 - (36%)	Gaps:	71/373 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 GGSAPIPGHSFDSGKDALLREDARLVLHKQNGTLSFASIIASDAGQYQCQLQLEAH--------A 362
            ||:  |..:..||.......:|:|  :|:||..|.|......|:|.|.|.::...:        :
  Rat    69 GGT--IIWYKNDSKTPISADKDSR--IHQQNEHLWFVPAKMEDSGYYYCIMRNSTYCLKTKITMS 129

  Fly   363 PINSSPGI-----LEVIEQLKFVPQPTSKNLELDAVVAKVHCKAQGTPTPQVQWVRDGENTTLPD 422
            .:.:.||:     ...|::|......:.....||      ..|.:....|:|||.::.:...|.|
  Rat   130 VLENDPGLCYNTQASFIQRLHVAGDGSLVCPYLD------FFKDENNELPKVQWYKNCKPLPLDD 188

  Fly   423 HVEVDANGTLIFRNVNSEHRGNYTCLATNS-QGQINATVAINVVVT--------PKFSVPPVGPI 478
            .........|:..||..||||||||..:.: ||:......:...:|        |....|....:
  Rat   189 GNFFGFKNKLMVMNVAEEHRGNYTCRTSYTYQGKQYPVTRVITFITIDDSKRDRPVIMSPRNETM 253

  Fly   479 ETSEQGTVVMHCQAIGD---------PKPTIQWDKDLKYLSENNTDRERFRFLENGTLE-----I 529
            |.....|:.:.|...|.         ....|:||..:  |:|:      ::|||:.:.:     |
  Rat   254 EADPGSTIQLICNVTGQFTDLVYWKWNGSEIEWDDPI--LAED------YQFLEHPSAKRKYTLI 310

  Fly   530 RNVQVEDEGS------YGCTIGNSAGLKREDVQLVVKTTGDGFAPEESGGDGFLVTRAVLITMTV 588
            ..:.|.:..|      :.|.:.|:..|:...|:||...  ..|.....||.......||.    .
  Rat   311 TTLNVSEVKSQFYRYPFICFVKNTHILETAHVRLVYPV--PDFKNYLIGGFAIFTATAVF----C 369

  Fly   589 ALAYIVLVVGLMLWCRYRRQAR---KARLNDLSTKEAGGDQPDVAGNG 633
            |..|.|..|.::||  ||....   ..:.:|..|.:|....|...|.|
  Rat   370 ACIYKVFKVDIVLW--YRDSCSDFLPPKASDGKTYDAYVLYPKTYGEG 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352
		Ig	31..115	CDD:299845
		IGc2	133..195	CDD:197706
		Ig	268..373	CDD:299845	18/79 (23%)
		Ig	395..460	CDD:143165	20/65 (31%)
		I-set	468..559	CDD:254352	22/110 (20%)
		IGc2	484..549	CDD:197706	16/84 (19%)
		PTK_CCK4	686..1026	CDD:133178
		STYKc	692..1020	CDD:214568
Il1r1	NP_037255.3	Ig	47..130	CDD:299845	16/64 (25%)
		Ig2_IL1R_like	144..236	CDD:143234	25/97 (26%)
		Ig_3	242..333	CDD:290638	18/98 (18%)
		IG_like	251..344	CDD:214653	19/100 (19%)
		TIR	401..556	CDD:214587	5/15 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910