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Protein Alignment otk and HMCN2

DIOPT Version :10

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_001278744.1	Gene:	HMCN2 / 256158	HGNCID:	21293	Length:	5079	Species:	Homo sapiens

Alignment Length:	971	Identity:	221/971 - (22%)
Similarity:	340/971 - (35%)	Gaps:	280/971 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SICGLVMALMMASVLASSSRFQRVPQSQSVVENESVKFECESTDSYSELHYDWLHNGHRIAYDKR 71
            |:..||......|:..||..|     ||.|    .||..| |...|...|..|......:..|.|
Human   599 SVWLLVREAPQVSIHTSSQHF-----SQGV----EVKVSC-SASGYPTPHISWSRESQALQEDSR 653

  Fly    72 VH-QIGSNLHIEAVRRTEDVGNYVCIATNLASGAREASPPAKLSVIYLESASVQ-----LLGSNR 130
            :| .....|.|:.| ..||.|||.|.|||.....:|.     :::.|.:..||.     :|.:..
Human   654 IHVDAQGTLIIQGV-APEDAGNYSCQATNEVGTDQET-----VTLYYTDPPSVSAVNAVVLVAVG 712

  Fly   131 NELLLKCHVEGASGDLEPLEIEWYRNS-------EKLSTWKNVQLDQHRLIIRQPGSE--DDGLY 186
            .|.:|.|...|    :.|..:.|||..       |..|:.|          :|.|.::  |.|.|
Human   713 EEAVLVCEASG----VPPPRVIWYRGGLEMILAPEGSSSGK----------LRIPAAQERDAGTY 763

  Fly   187 RCTASNAAGRVMSKQGYVYQSSVKCLPRLPRRKNEKMMESWDKQTFLCRG----------KRG-- 239
            .|.|.|..|...::    .|.:|...|:|.....:..:|........||.          :||
Human   764 TCRAVNELGDASAE----IQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDG 824

  Fly   240 ---------GAAGLEALP---------AAPEDLR-------------------IVQGPIGQSI-- 265
                     |.......|         .||||..                   ||.|.....|
Human   825 QPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIAS 889

  Fly   266 ------IKEGEPTALTCLY----ELPDELKNQRIQLRWRKDGKLLRQVELGGSAPIPGHSFDSGK 320
                  :.||:|.:|.|:.    .||:.        .|.|||:           |:|..|..|
Human   890 SAPTVRVLEGQPVSLPCIVLAGRPLPER--------HWLKDGR-----------PLPPGSRHS-- 933

  Fly   321 DALLREDARLVLHKQNGTLSFASIIASDAGQYQCQLQLEAHAPINSSPGILEVIEQLKFVPQPT- 384
               :|.|         |:|.....:...||:|.|    .|.....|....:|::.|:.....||
Human   934 ---IRAD---------GSLHLDRALQEHAGRYSC----VATNTAGSQHRDVELVVQVPPRIHPTA 982

  Fly   385 SKNLELDAVVAKVHCKAQGTPTPQVQWVRD-GENTTLPDHVEVDANGTLIFRNVNSEHRGNYTCL 448
            :.::..:.|.|.:.|.|.|.|.|.:.|.:: ...|:...|..|...|||:....:::..|.|.|.
Human   983 THHITNEGVAASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCT 1047

  Fly   449 ATNSQGQINATVAINVVVTPKF--------SVPPVGPIETSEQGTVVMHCQAIGDPKPTIQWDKD 505
            |||:.|..:..:.::|...|:.        .||.....:..|:  |.:.|:|.|.|.|.:.|.||
Human  1048 ATNTVGFSSQEMRLSVNTKPRIHMNGSRNADVPLQVTAKAGEE--VTLDCEAKGSPPPLVTWTKD 1110

  Fly   506 LKYLSENNTDRERFRFLENGTLEIRNVQVEDEGSYGCTIGNSAGLKREDVQLVVKTTGDGFAPEE 570
            .:.:....   .|:..|.:|:|.:..|||.|.|.|.||..|.||.......|.|:.     .|:.
Human  1111 SRPVPPIT---NRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQV-----PPQV 1167

  Fly   571 SGGDGFLVTRAVLITMTVALAYIVLVVGLMLWCRYRRQARKARLNDLSTKEAGGDQPDVA----- 630
            ..|...|                .::||..|              ||:....|..:|.::
Human  1168 QPGPRVL----------------KVLVGEAL--------------DLNCVAEGNPEPQLSWSKDG 1202

  Fly   631 ----GNG-KGSEQEPCLSKQHNGHSKSRSKSSG--DAQKSDDTACSQQSRASKKSAHIYEQLA-- 686
                |.| :||.....:.....|..:..:.:|.  ||.:.:..........:.:::.:.|::|
Human  1203 VVLQGRGPQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGE 1267

  Fly   687 ---LP-------------RSGLSELIQIGRG-----EFGDVFVGKLKATLVTSPSDKDADTEKQH 730
               ||             |.|.|.....|:.     |.|.:|:..:      ||:| ..|.|.|.
Human  1268 NASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASV------SPAD-SGDYECQA 1325

  Fly   731 SNSENGSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSGL--EQLVL--------V 785
            :|.        .|||:       ||:|..:.....|:|:.: :.|.||:  :.|.|        |
Human  1326 TNE--------VGSTS-------RRAKLVVYVPPSIREDGR-KANVSGMAGQSLTLECDANGFPV 1374

  Fly   786 KALNKVKDEQACQEF--RRQLDLLRAIS----HKGVVRLFGLCR--------EKDPHYMVL 832
            ..:..:||.|...:.  .|.||..:::.    .:|...|:. ||        ::|.|.:||
Human  1375 PEIVWLKDAQLIPKVGGHRLLDEGQSLHFPRIQEGDSGLYS-CRAENQAGTAQRDFHLLVL 1434

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.