DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otk and Ntrk2

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	XP_008769647.1	Gene:	Ntrk2 / 25054	RGDID:	3213	Length:	837	Species:	Rattus norvegicus

Alignment Length:	1096	Identity:	245/1096 - (22%)
Similarity:	397/1096 - (36%)	Gaps:	346/1096 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ARMISICGLVMALMMASVL------ASSSRFQRVPQSQSVVENESVKFECESTDSYSELHYDWLH 61
            ||:..:|.||:....||:.      .|::|......|..:|....::......::.:|:
  Rat    13 ARLWGLCLLVLGFWRASLACPMSCKCSTTRIWCTEPSPGIVAFPRLEPNSIDPENITEI------ 71

  Fly    62 NGHRIAYDKRVHQIGSNLHIEAVRRTEDVGNYVCI--ATNLASGAREASPPAKLSVIYLESASVQ 124
               .||..||:..|..          :||..||.:  .|.:.||.:..:..|     :|::.:::
  Rat    72 ---LIANQKRLEIINE----------DDVEAYVGLKNLTIVDSGLKFVAYKA-----FLKNGNLR 118

  Fly   125 LLGSNRNEL--LLKCHVEGASGDLEPL-----------EIEWYRNSEKLSTWKNVQLDQHRLIIR 176
            .:...||:|  |.:.|....  ||..|           :|.|.:..::..:
  Rat   119 HINFTRNKLTSLSRRHFRHL--DLSDLILTGNPFTCSCDIMWLKTLQETKS-------------- 167

  Fly   177 QPGSEDDGLYRCTASNAAGRVMSKQGYVYQSSVKCLPRLPRRKNEKMMESWDKQTFLCRGKRGGA 241
            .|.::|  ||                        ||       ||.     .|.|.|
  Rat   168 SPDTQD--LY------------------------CL-------NES-----SKNTPL-------- 186

  Fly   242 AGLE----ALP----AAPEDLRIVQGPIGQSIIKEGEPTALTCLYELPDELKNQRIQLRWRKDGK 298
            |.|:    .||    |||           ...::||:...::|
  Rat   187 ANLQIPNCGLPSARLAAP-----------NLTVEEGKSVTISC---------------------- 218

  Fly   299 LLRQVELGGSAPIPGHSFDSGKDALLREDARLVLHKQNGTLSFASIIASDAG-QYQC-------Q 355
                 .:||. |:|...:|.|.  |:.:......|.| |:|...:|.:.|:| |..|       :
  Rat   219 -----SVGGD-PLPTLYWDVGN--LVSKHMNETSHTQ-GSLRITNISSDDSGKQISCVAENLVGE 274

  Fly   356 LQLEAHAPINSSPGILEVIEQLKFVPQPTSKNLELDAVVAKVH-C---KAQGTPTPQVQWVRDG- 415
            .|...:..::.:|.|       .|:..|||.:          | |   ..:|.|.|.:||..:|
  Rat   275 DQDSVNLTVHFAPTI-------TFLESPTSDH----------HWCIPFTVRGNPKPALQWFYNGA 322

  Fly   416 ---ENTTLPDHVEV----DANGTLIFRNVNSEHRGNYTCLATNSQGQINATVAINVVVTPKFSVP 473
               |:..:...:.|    :.:|.|...|....:.|:||.:|.|..|:
  Rat   323 ILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLMAKNEYGK------------------ 369

  Fly   474 PVGPIETSEQGTVVMHCQAIGDPKPTIQWDKDLKY---LSENNTDRERFRFLENGTLEIRNVQVE 535
                    ::..:..|...    :|.:.::.:..|   |.|:.|.........|.:.||.:..|.
  Rat   370 --------DERQISAHFMG----RPGVDYETNPNYPEVLYEDWTTPTDIGDTTNKSNEIPSTDVA 422

  Fly   536 DEGSYGCTIGNSAGLKREDVQLVVKTTGDGFAPEESGGDGFLVTRAVLITMTVALAYIVLVVGLM 600
            |:            ..||.:.                     |...|:|...|....:|:::.|.
  Rat   423 DQ------------TNREHLS---------------------VYAVVVIASVVGFCLLVMLLLLK 454

  Fly   601 LWCRYRRQARKARLNDLSTKEAGGDQPDVAGNGKGSEQEPCLSKQHNGHSKSRSKSSGDAQKSDD 665
            |       ||.::..          ..||:..|.|..:    |:|..|.:   |..|.|    ||
  Rat   455 L-------ARHSKFG----------MKDVSWFGIGKVK----SRQGVGPA---SVISND----DD 491

  Fly   666 TACSQQSRASKKSAHIYEQLALPRSGLSELIQIGRGEFGDVFVGKLKATLVTSP-------SDKD 723
            :|....        ||......|.|        ..|....|.:|..|..::.:|       |...
  Rat   492 SASPLH--------HISNGSNTPSS--------SEGGPDAVIIGMTKIPVIENPQYFGITNSQLK 540

  Fly   724 ADTEKQHSNSEN-------GSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSGLEQ 781
            .||..||....|       |.|..|               |..:.:...:..|:.        :.
  Rat   541 PDTFVQHIKRHNIVLKRELGEGAFG---------------KVFLAECYNLCPEQD--------KI 582

  Fly   782 LVLVKALNKVKDEQACQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFLLA 846
            ||.||.|....| .|.::|.|:.:||..:.|:.:|:.:|:|.|.||..||.||...|||.:||.|
  Rat   583 LVAVKTLKDASD-NARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRA 646

  Fly   847 TAGKVNTATAGSSSPPPLTTSQVLAVAYQIARGMDAIYRARFTHRDLATRNCVISSEFIVKVSYP 911
             .|......|..:.|..||.||:|.:|.|||.||..:....|.|||||||||::....:||:...
  Rat   647 -HGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDF 710

  Fly   912 ALCKDKYSREYHK-HRNTLLPIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQATKLPHEELTN 975
            .:.:|.||.:|:: ..:|:|||||:.||.|...::||:||:::.|||:||:|... |.|..:|:|
  Rat   711 GMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYG-KQPWYQLSN 774

  Fly   976 EQVVQRSQAGSLEWSVAEATPDSLREILLSCWVSNPKERPSFSQLGAALSKAMQSA 1031
            .:|::....|.: .......|..:.|::|.||...|..|.:...:...|....:::
  Rat   775 NEVIECITQGRV-LQRPRTCPQEVYELMLGCWQREPHTRKNIKNIHTLLQNLAKAS 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352	17/90 (19%)
		Ig	31..115	CDD:299845	16/85 (19%)
		IGc2	133..195	CDD:197706	12/74 (16%)
		Ig	268..373	CDD:299845	22/112 (20%)
		Ig	395..460	CDD:143165	19/76 (25%)
		I-set	468..559	CDD:254352	13/93 (14%)
		IGc2	484..549	CDD:197706	11/67 (16%)
		PTK_CCK4	686..1026	CDD:133178	109/354 (31%)
		STYKc	692..1020	CDD:214568	106/342 (31%)
Ntrk2	XP_008769647.1	LRR_8	92..150	CDD:404697	13/64 (20%)
		TPKR_C2	152..195	CDD:407151	15/102 (15%)
		Ig	205..283	CDD:416386	20/108 (19%)
		Ig strand A'	205..209	CDD:409353	0/3 (0%)
		Ig strand B	212..221	CDD:409353	1/35 (3%)
		Ig strand D	238..243	CDD:409353	0/4 (0%)
		Ig strand E	244..254	CDD:409353	4/10 (40%)
		Ig strand F	261..270	CDD:409353	3/8 (38%)
		Ig strand G	273..283	CDD:409353	1/9 (11%)
		IgI_TrkB_d5	286..379	CDD:409441	26/135 (19%)
		Ig strand B	301..305	CDD:409441	1/3 (33%)
		Ig strand C	314..318	CDD:409441	1/3 (33%)
		Ig strand E	344..348	CDD:409441	2/3 (67%)
		Ig strand F	358..363	CDD:409441	2/4 (50%)
		Ig strand G	371..374	CDD:409441	0/2 (0%)
		PTKc_TrkB	547..834	CDD:270675	98/310 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1026
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810