DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otk and Ntrk2

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_001020245.1	Gene:	Ntrk2 / 18212	MGIID:	97384	Length:	821	Species:	Mus musculus

Alignment Length:	1088	Identity:	237/1088 - (21%)
Similarity:	388/1088 - (35%)	Gaps:	346/1088 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ARMISICGLVMALMMASVL------ASSSRFQRVPQSQSVVENESVKFECESTDSYSELHYDWLH 61
            ||:..:|.||:....||:.      .||:|......|..:|....::......::.:|:
Mouse    13 ARLWGLCLLVLGFWRASLACPTSCKCSSARIWCTEPSPGIVAFPRLEPNSVDPENITEI------ 71

  Fly    62 NGHRIAYDKRVHQIGSNLHIEAVRRTEDVGNYVCI--ATNLASGAREASPPAKLSVIYLESASVQ 124
               .||..||:..|..          :||..||.:  .|.:.||.:..:..|     :|::::::
Mouse    72 ---LIANQKRLEIINE----------DDVEAYVGLRNLTIVDSGLKFVAYKA-----FLKNSNLR 118

  Fly   125 LLGSNRNEL--LLKCHVEGASGDLEPL-----------EIEWYRNSEKLSTWKNVQLDQHRLIIR 176
            .:...||:|  |.:.|....  ||..|           :|.|.:..::..:
Mouse   119 HINFTRNKLTSLSRRHFRHL--DLSDLILTGNPFTCSCDIMWLKTLQETKS-------------- 167

  Fly   177 QPGSEDDGLYRCTASNAAGRVMSKQGYVYQSSVKCLPRLPRRKNEKMMESWDKQTFLCRGKRGGA 241
            .|.::|  ||                        ||     .::.|.|...:.|...|
Mouse   168 SPDTQD--LY------------------------CL-----NESSKNMPLANLQIPNC------- 194

  Fly   242 AGLEALPAAPEDLRIVQGPIGQSIIKEGEPTALTCLYELPDELKNQRIQLRWRKDGKLLRQVELG 306
             ||.:...|..:|          .::||:...|:|                           .:|
Mouse   195 -GLPSARLAAPNL----------TVEEGKSVTLSC---------------------------SVG 221

  Fly   307 GSAPIPGHSFDSGKDALLREDARLVLHKQNGTLSFASIIASDAG-QYQC-------QLQLEAHAP 363
            |. |:|...:|.|.  |:.:......|.| |:|...:|.:.|:| |..|       :.|...:..
Mouse   222 GD-PLPTLYWDVGN--LVSKHMNETSHTQ-GSLRITNISSDDSGKQISCVAENLVGEDQDSVNLT 282

  Fly   364 INSSPGILEVIEQLKFVPQPTSKNLELDAVVAKVH-C---KAQGTPTPQVQWVRDG----ENTTL 420
            ::.:|.|       .|:..|||.:          | |   ..:|.|.|.:||..:|    |:..:
Mouse   283 VHFAPTI-------TFLESPTSDH----------HWCIPFTVRGNPKPALQWFYNGAILNESKYI 330

  Fly   421 PDHVEV----DANGTLIFRNVNSEHRGNYTCLATNSQGQINATVAINVVVTPKFSVPPVGPIETS 481
            ...:.|    :.:|.|...|....:.|:||.:|.|..|:
Mouse   331 CTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLMAKNEYGK-------------------------- 369

  Fly   482 EQGTVVMHCQAIGDPKPTIQWDKDLKY---LSENNTDRERFRFLENGTLEIRNVQVEDEGSYGCT 543
            ::..:..|...    :|.:.::.:..|   |.|:.|.........|.:.||.:..|.|:.:
Mouse   370 DERQISAHFMG----RPGVDYETNPNYPEVLYEDWTTPTDIGDTTNKSNEIPSTDVADQSN---- 426

  Fly   544 IGNSAGLKREDVQLVVKTTGDGFAPEESGGDGFLVTRAVLITMTVALAYIVLVVGLMLWCRYRRQ 608
                    ||.:.                     |...|:|...|....:|:::.|.|
Mouse   427 --------REHLS---------------------VYAVVVIASVVGFCLLVMLLLLKL------- 455

  Fly   609 ARKARLNDLSTKEAGGDQPDVAGNGKGSEQEPCLSKQHNGHSKSRSKSSGDAQKSDDTACSQQSR 673
               ||                                   |||...|.......:||.:.|...
Mouse   456 ---AR-----------------------------------HSKFGMKGPASVISNDDDSASPLH- 481

  Fly   674 ASKKSAHIYEQLALPRSGLSELIQIGRGEFGDVFVGKLKATLVTSP-------SDKDADTEKQHS 731
                  ||......|.|        ..|....|.:|..|..::.:|       |....||..||.
Mouse   482 ------HISNGSNTPSS--------SEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHI 532

  Fly   732 NSEN-------GSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSGLEQLVLVKALN 789
            ...|       |.|..|               |..:.:...:..|:.        :.||.||.|.
Mouse   533 KRHNIVLKRELGEGAFG---------------KVFLAECYNLCPEQD--------KILVAVKTLK 574

  Fly   790 KVKDEQACQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFLLATAGKVNTA 854
            ...| .|.::|.|:.:||..:.|:.:|:.:|:|.|.||..||.||...|||.:||.| .|.....
Mouse   575 DASD-NARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRA-HGPDAVL 637

  Fly   855 TAGSSSPPPLTTSQVLAVAYQIARGMDAIYRARFTHRDLATRNCVISSEFIVKVSYPALCKDKYS 919
            .|..:.|..||.||:|.:|.|||.||..:....|.|||||||||::....:||:....:.:|.||
Mouse   638 MAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYS 702

  Fly   920 REYHK-HRNTLLPIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQATKLPHEELTNEQVVQRSQ 983
            .:|:: ..:|:|||||:.||.|...::||:||:::.|||:||:|... |.|..:|:|.:|::...
Mouse   703 TDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYG-KQPWYQLSNNEVIECIT 766

  Fly   984 AGSLEWSVAEATPDSLREILLSCWVSNPKERPSFSQLGAALSKAMQSA 1031
            .|.: .......|..:.|::|.||...|..|.:...:...|....:::
Mouse   767 QGRV-LQRPRTCPQEVYELMLGCWQREPHTRKNIKSIHTLLQNLAKAS 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352	17/90 (19%)
		Ig	31..115	CDD:299845	16/85 (19%)
		IGc2	133..195	CDD:197706	12/74 (16%)
		Ig	268..373	CDD:299845	23/112 (21%)
		Ig	395..460	CDD:143165	19/76 (25%)
		I-set	468..559	CDD:254352	13/93 (14%)
		IGc2	484..549	CDD:197706	11/67 (16%)
		PTK_CCK4	686..1026	CDD:133178	109/354 (31%)
		STYKc	692..1020	CDD:214568	106/342 (31%)
Ntrk2	NP_001020245.1	LRR_8	92..150	CDD:338972	13/64 (20%)
		LRR 1	92..113		4/25 (16%)
		LRR 2	116..137		5/20 (25%)
		TPKR_C2	152..195	CDD:374888	12/95 (13%)
		Ig	205..283	CDD:386229	22/118 (19%)
		Ig_TrkB_d5	301..379	CDD:143263	19/103 (18%)
		Interaction with MAPK8IP3/JIP3. /evidence=ECO:0000250\|UniProtKB:Q63604	454..465		6/55 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..497		7/37 (19%)
		PTKc_TrkB	531..818	CDD:270675	98/310 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1026
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810