DRSC/TRiP Functional Genomics Resources

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Protein Alignment otk and Ntrk1

DIOPT Version :10

Sequence 1:NP_523705.2 Gene:otk / 36283 FlyBaseID:FBgn0004839 Length:1033 Species:Drosophila melanogaster
Sequence 2:NP_001028296.1 Gene:Ntrk1 / 18211 MGIID:97383 Length:799 Species:Mus musculus


Alignment Length:852 Identity:201/852 - (23%)
Similarity:302/852 - (35%) Gaps:270/852 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   255 RIVQGPIGQSIIKEGEPTALTC-LYELPDELKNQRIQLRWRKDGKL-LRQVELGGSAP------- 310
            :.|||...|.:...|.|...:| |:.|.          ||.::|.. :....|..|.|       
Mouse   133 KTVQGLSLQDLTLSGNPLHCSCALFWLQ----------RWEQEGLCGVHTQTLHDSGPGDQFLPL 187

  Fly   311 --------------IPGHSFDSGKDALLR--------EDARLVLHKQNGTLS---FASI------ 344
                          :|..|.:.|.|..|:        :.|..:|.:..|..:   |..:      
Mouse   188 GHNTSCGVPTVKIQMPNDSVEVGDDVFLQCQVEGLALQQADWILTELEGAATVKKFGDLPSLGLI 252

  Fly   345 ---IASDAGQYQCQLQLEAHAPINSSPGILEVIEQLKFVPQPTSKNLELDAVVAKVHC---KAQG 403
               :.||..:.......|      :..|..||..|:. |..|.|.:|.| ||.....|   ...|
Mouse   253 LVNVTSDLNKKNVTCWAE------NDVGRAEVSVQVS-VSFPASVHLGL-AVEQHHWCIPFSVDG 309

  Fly   404 TPTPQVQWVRDGENTTLPDHV-----------EVDANGTLIFRNVNSEHRGNYTCLATNSQGQIN 457
            .|.|.::|:.:|........:           |...:|.|........:.||||.||.|..||..
Mouse   310 QPAPSLRWLFNGSVLNETSFIFTQFLESALTNETMRHGCLRLNQPTHVNNGNYTLLAANPYGQAA 374

  Fly   458 ATVAINVVVTPKFSVPPVGPIETSEQGTVVMHCQAIGDPKPTIQWDKDLKYLSENNTDRERFRFL 522
            |:|....:..| |...|..||..|                        ...:..|:|.|:     
Mouse   375 ASVMAAFMDNP-FEFNPEDPIPVS------------------------FSPVDGNSTSRD----- 409

  Fly   523 ENGTLEIRNVQVEDEGSYGCTI----GNSAGLKREDVQLVVKTTGDG----------FAPEESGG 573
                    .|:.:||..:|.::    ..||.|....:.||:...|..          .|||    
Mouse   410 --------PVEKKDETPFGVSVAVGLAVSAALFLSALLLVLNKCGQRSKFGINRPAVLAPE---- 462

  Fly   574 DGFLVTRAVLITMTVALAYIVLVVGLMLWCRYRRQARKARLNDLSTKEAGGDQPDVAGNGKGSEQ 638
            ||          :.::|.::.|                          .|.......|.|.|.: 
Mouse   463 DG----------LAMSLHFMTL--------------------------GGSSLSPTEGKGSGLQ- 490

  Fly   639 EPCLSKQHNGHSKSRSKSSGDAQKSDDTACSQQSRASKKSAHIYEQLALPRSGLSELI---QIGR 700
                     ||...      :.|...||...          ||..|         ::|   ::|.
Mouse   491 ---------GHIME------NPQYFSDTCVH----------HIKRQ---------DIILKWELGE 521

  Fly   701 GEFGDVFVGKLKATLVTSPSDKDADTEKQHSNSENGSGGSGSGSTTLSTLNEKRRSKTSMDDIEE 765
            |.||.||:.:....|    :|:|                                          
Mouse   522 GAFGKVFLAECYNLL----NDQD------------------------------------------ 540

  Fly   766 IKEEEQDQHNQSGLEQLVLVKALNKVKDEQACQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYM 830
                          :.||.|||| |...|.|.|:|:|:.:||..:.|:.:||.||:|.|..|..|
Mouse   541 --------------KMLVAVKAL-KEASENARQDFQREAELLTMLQHQHIVRFFGVCTEGGPLLM 590

  Fly   831 VLEYTDWGDLKQFLLATAGKVNTATAGSS-SPPPLTTSQVLAVAYQIARGMDAIYRARFTHRDLA 894
            |.||...|||.:||.:..........|.. :|.||...|:||||.|:|.||..:....|.|||||
Mouse   591 VFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLASLHFVHRDLA 655

  Fly   895 TRNCVISSEFIVKVSYPALCKDKYSREYHK-HRNTLLPIRWLAPECIQEDEYTTKSDIFAYGVVV 958
            ||||::....:||:....:.:|.||.:|:: ...|:|||||:.||.|...:::|:||::::|||:
Mouse   656 TRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFSTESDVWSFGVVL 720

  Fly   959 WELFNQATKLPHEELTNEQVVQRSQAGSLEWSVAEATPDSLREILLSCWVSNPKERPSFSQLGAA 1023
            ||:|... |.|..:|:|.:.::....|. |.....|.|..:..|:..||...|::|.|...:.|.
Mouse   721 WEIFTYG-KQPWYQLSNTEAIECITQGR-ELERPRACPPDVYAIMRGCWQREPQQRLSMKDVHAR 783

  Fly  1024 LSKAMQS 1030
            |....|:
Mouse   784 LQALAQA 790

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
otkNP_523705.2 Ig_3 31..99 CDD:464046
Ig strand B 133..137 CDD:409353
Ig <135..197 CDD:472250
Ig strand C 150..154 CDD:409353
Ig strand E 171..175 CDD:409353
Ig strand F 185..190 CDD:409353
Ig 265..360 CDD:472250 22/137 (16%)
Ig strand B 272..276 CDD:409571 0/3 (0%)
Ig strand C 290..294 CDD:409571 1/3 (33%)
Ig strand E 337..341 CDD:409571 1/6 (17%)
Ig strand F 351..356 CDD:409571 0/4 (0%)
Ig 395..460 CDD:409353 19/78 (24%)
Ig strand B 395..399 CDD:409353 0/3 (0%)
Ig strand C 408..412 CDD:409353 0/3 (0%)
Ig strand E 430..434 CDD:409353 2/3 (67%)
Ig strand F 444..449 CDD:409353 3/4 (75%)
Ig strand G 457..460 CDD:409353 1/2 (50%)
I-set 468..559 CDD:400151 17/94 (18%)
Ig strand B 486..490 CDD:409570 0/3 (0%)
Ig strand C 499..503 CDD:409570 0/3 (0%)
Ig strand E 525..529 CDD:409570 0/3 (0%)
Ig strand F 539..544 CDD:409570 1/4 (25%)
Ig strand G 552..555 CDD:409570 0/2 (0%)
PTK_CCK4 686..1026 CDD:133178 104/344 (30%)
Ntrk1NP_001028296.1 leucine-rich repeat 68..92 CDD:275378
LRR 1 90..113
LRR_8 92..150 CDD:404697 5/16 (31%)
leucine-rich repeat 93..116 CDD:275378
LRR 2 116..137 1/3 (33%)
leucine-rich repeat 117..139 CDD:275378 3/5 (60%)
leucine-rich repeat 140..152 CDD:275378 3/11 (27%)
LRRCT_2 151..194 CDD:465313 9/52 (17%)
Ig 197..284 CDD:472250 16/93 (17%)
Ig strand B 213..217 CDD:409353 1/3 (33%)
Ig strand C 226..230 CDD:409353 1/3 (33%)
Ig strand E 249..253 CDD:409353 0/3 (0%)
Ig strand F 264..269 CDD:409353 0/4 (0%)
Ig strand G 277..280 CDD:409353 2/2 (100%)
IgI_TrKABC_d5 287..382 CDD:409360 26/95 (27%)
Ig strand A 287..293 CDD:409360 2/5 (40%)
Ig strand A' 295..298 CDD:409360 2/2 (100%)
Ig strand B 301..309 CDD:409360 1/7 (14%)
Ig strand C 312..319 CDD:409360 2/6 (33%)
Ig strand C' 322..325 CDD:409360 0/2 (0%)
Ig strand D 330..336 CDD:409360 0/5 (0%)
Ig strand E 344..352 CDD:409360 2/7 (29%)
Ig strand F 360..368 CDD:409360 6/7 (86%)
Ig strand G 371..379 CDD:409360 4/7 (57%)
Interaction with SQSTM1. /evidence=ECO:0000250 472..493 6/56 (11%)
Protein Kinases, catalytic domain 507..786 CDD:473864 107/350 (31%)
Blue background indicates that the domain is not in the aligned region.

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