DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment otk and Mag

DIOPT Version :9

Sequence 1:NP_523705.2 Gene:otk / 36283 FlyBaseID:FBgn0004839 Length:1033 Species:Drosophila melanogaster
Sequence 2:NP_001333013.1 Gene:Mag / 17136 MGIID:96912 Length:627 Species:Mus musculus


Alignment Length:536 Identity:115/536 - (21%)
Similarity:175/536 - (32%) Gaps:186/536 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   269 GEPTALTCLYELPDELKNQRIQLRWRKDGKLLRQVELG----GSAPIPGHSFDSGKDALLREDAR 329
            |....::|:  :||.....|.:|.|           ||    |...:.|.         ||||  
Mouse   152 GTEVEVSCM--VPDNCPELRPELSW-----------LGHEGLGEPTVLGR---------LRED-- 192

  Fly   330 LVLHKQNGT------LSFASIIASDAGQYQCQ-------LQLEAHAPINSSPGILEVIEQLKFVP 381
                  .||      |.|.....::..:..||       ||.|.:|.::           :|:.|
Mouse   193 ------EGTWVQVSLLHFVPTREANGHRLGCQAAFPNTTLQFEGYASLD-----------VKYPP 240

  Fly   382 QPTSKNLELDAVV---AKVHCKAQGTPTPQVQWVRDGENTTLPDHVEVDANGTLIFRNVNSEHRG 443
            .....|..::|:.   ..:.|.|...|.|.:.|:|||  ..|.:.|....  .|....|.....|
Mouse   241 VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDG--MVLREAVAKSL--YLDLEEVTPGEDG 301

  Fly   444 NYTCLATNSQGQINATVAINVVVTPKFSVPPV-GPIETSEQGTVVMHCQAIGDPKPTIQWDKDLK 507
            .|.|||.|:.||.|.||.::|:..|  ..|.| |.:...|..||.:.|....:|.|.:...|:.:
Mouse   302 VYACLAENAYGQDNRTVELSVMYAP--WKPTVNGTVVAVEGETVSILCSTQSNPDPILTIFKEKQ 364

  Fly   508 YLS----ENNTDRERFRFLENGTLEIRNVQVEDEGSYGCTIGNSAGLK----------------- 551
            .|:    |:...           ||:..|..||:|.|.|...|..|.:                 
Mouse   365 ILATVIYESQLQ-----------LELPAVTPEDDGEYWCVAENQYGQRATAFNLSVEFAPIILLE 418

  Fly   552 ------REDVQ--LVVKTTGDGFAPEESGG----------------------DGFLVTRAVLI-- 584
                  |:.||  .|||:.     ||.|..                      .|.|:|..:.|  
Mouse   419 SHCAAARDTVQCLCVVKSN-----PEPSVAFELPSRNVTVNETEREFVYSERSGLLLTSILTIRG 478

  Fly   585 -----------------TMTVAL-----------------AYIVLVVGLMLWCRYRRQARKARLN 615
                             |.::.|                 |.:...:.:.:.|...:..||..:.
Mouse   479 QAQAPPRVICTSRNLYGTQSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVT 543

  Fly   616 DLSTKEAGGDQPDV--------AGNGKGSEQEPCLSKQHNGHSKSRSKSSGDAQKSDDTACSQQ- 671
            : |:..:|||.|.|        :|.....|.|    ||..|..:......|::.:.|.:..... 
Mouse   544 E-SSSFSGGDNPHVLYSPEFRISGAPDKYESE----KQRLGSERRLLGLRGESPELDLSYSHSDL 603

  Fly   672 -SRASKKSAHIYEQLA 686
             .|.:|.|..:.|:||
Mouse   604 GKRPTKDSYTLTEELA 619

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
otkNP_523705.2 I-set 26..115 CDD:254352
Ig 31..115 CDD:299845
IGc2 133..195 CDD:197706
Ig 268..373 CDD:299845 25/120 (21%)
Ig 395..460 CDD:143165 21/64 (33%)
I-set 468..559 CDD:254352 26/120 (22%)
IGc2 484..549 CDD:197706 17/68 (25%)
PTK_CCK4 686..1026 CDD:133178 1/1 (100%)
STYKc 692..1020 CDD:214568
MagNP_001333013.1 Interaction with RTN4R and RTN4RL2. /evidence=ECO:0000250|UniProtKB:P07722 20..325 53/217 (24%)
IgV_CD33 22..137 CDD:409377
Ig strand B 38..42 CDD:409377
Ig strand C 56..60 CDD:409377
Ganglioside GT1b binding. /evidence=ECO:0000269|PubMed:27922006 65..67
Ig strand E 100..104 CDD:409377
Ig strand F 114..119 CDD:409377
Ganglioside GT1b binding. /evidence=ECO:0000269|PubMed:27922006 124..128
Ig strand G 128..133 CDD:409377
IgC2_CD33_d2_like 141..235 CDD:409579 25/112 (22%)
Ig strand B 155..159 CDD:409579 0/3 (0%)
Ig strand C 171..175 CDD:409579 2/14 (14%)
Ig strand E 200..204 CDD:409579 1/3 (33%)
Ig strand F 214..219 CDD:409579 1/4 (25%)
Ig strand G 229..232 CDD:409579 1/2 (50%)
Ig_3 239..309 CDD:404760 20/73 (27%)
Ig strand A 239..242 CDD:409353 1/2 (50%)
Ig strand A' 248..251 CDD:409353 0/2 (0%)
Ig strand B 256..264 CDD:409353 1/7 (14%)
Ig strand C 270..274 CDD:409353 0/3 (0%)
Ig strand C' 277..280 CDD:409353 1/4 (25%)
Ig strand E 289..293 CDD:409353 1/3 (33%)
Ig strand F 301..309 CDD:409353 5/7 (71%)
Ig strand G 312..322 CDD:409353 5/9 (56%)
IG 333..409 CDD:214652 20/86 (23%)
Required for normal axon myelination in the central nervous system. /evidence=ECO:0000269|PubMed:9482783 578..627 9/42 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4475
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.