DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment otk and Il1rap

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_001152790.1	Gene:	Il1rap / 16180	MGIID:	104975	Length:	685	Species:	Mus musculus

Alignment Length:	657	Identity:	134/657 - (20%)
Similarity:	226/657 - (34%)	Gaps:	211/657 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 EGEPTALTC-LYELPDELK-------NQRIQLRW---RKDGKLLRQVELGGSAPIPGHSFDSGKD 321
            |.||..:.| |:|  ..||       :..:.|.|   |:|    |.:|...:..:|.:.....||
Mouse    39 EDEPARIKCPLFE--HFLKYNYSTAHSSGLTLIWYWTRQD----RDLEEPINFRLPENRISKEKD 97

  Fly   322 ALLREDARLVLHKQNGTLSFASIIASDAGQYQCQLQLEAHAPINSSPGILEVIEQ-------LKF 379
            .|.                |...:.:|.|.|.|.|:...:....:.|  |||:::       ::|
Mouse    98 VLW----------------FRPTLLNDTGNYTCMLRNTTYCSKVAFP--LEVVQKDSCFNSAMRF 144

  Fly   380 VPQPTSKNLELDAVVAKVHC-KAQG----TPTPQVQWVR------DGENTTLPDHVEVDANGTLI 433
               |..| :.::..:.|:.| ...|    :..|.|.|.:      |..| .||:.:.:.....|:
Mouse   145 ---PVHK-MYIEHGIHKITCPNVDGYFPSSVKPSVTWYKGCTEIVDFHN-VLPEGMNLSFFIPLV 204

  Fly   434 FRNVNSEHRGNYTCLATNSQG----QINATVAINVVVTPKFSVPP---------VGPIETSEQGT 485
            ..|      |||||:.|..:.    .:..||.:.||.:||.::||         |...|..|:
Mouse   205 SNN------GNYTCVVTYPENGRLFHLTRTVTVKVVGSPKDALPPQIYSPNDRVVYEKEPGEE-- 261

  Fly   486 VVMHCQA----IGDPKPTIQWDKDLK-------------YLSENNTDRERFRFLENGTLEIRNVQ 533
            :|:.|:.    |.|....:.|..|.|             .:|.::|:.|    .....|.|:.|.
Mouse   262 LVIPCKVYFSFIMDSHNEVWWTIDGKKPDDVTVDITINESVSYSSTEDE----TRTQILSIKKVT 322

  Fly   534 VED-EGSYGCTIGNSAGLKREDVQLVVKTTGDGFAPEESGGDGFLVTRAVLITMTVALAYIVLVV 597
            .|| ..:|.|...|:.|...:..::..|.....:..|.:.|.|          .||.|..:::||
Mouse   323 PEDLRRNYVCHARNTKGEAEQAAKVKQKVIPPRYTVELACGFG----------ATVFLVVVLIVV 377

  Fly   598 GLMLWCR----YRRQARKARLNDLSTKEA--GGDQPDV-AGNGKGSEQEP--------------- 640
            ..:.|..    ||..        ..|.|.  .|.:.|: ....:..|:|.
Mouse   378 YHVYWLEMVLFYRAH--------FGTDETILDGKEYDIYVSYARNVEEEEFVLLTLRGVLENEFG 434

  Fly   641 ---CLSKQHN---GHS---------KSR------------SKSSGDAQKSDDTACSQQSRASKKS 678
               |:..:.:   |::         :||            .||....:......| |.|.|:|..
Mouse   435 YKLCIFDRDSLPGGNTVEAVFDFIQRSRRMIVVLSPDYVTEKSISMLEFKLGVMC-QNSIATKLI 498

  Fly   679 AHIYEQLALPRSGLSELIQIGRGEFGDVFVGKLKATLVTSPSDKDADTEKQHSNSE--------- 734
            ...|..|..|..|:.:|              |...:.|:...:|     .:||.|:
Mouse   499 VVEYRPLEQPHPGIMQL--------------KESVSFVSWKGEK-----SKHSGSKFWKALRLAL 544

  Fly   735 --------NGSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSGLEQLVLVKALNKV 791
                    :|...|.|..:.:|..:.:|||:  :.:..|::..|:    .||.|......:.::.
Mouse   545 PLRSLSASSGWNESCSSQSDISLDHVQRRSR--LKEPPELRSSER----VSGAEPAPGTMSKHRG 603

  Fly   792 KDEQACQ 798
            |...||:
Mouse   604 KPSAACR 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352
		Ig	31..115	CDD:299845
		IGc2	133..195	CDD:197706
		Ig	268..373	CDD:299845	26/115 (23%)
		Ig	395..460	CDD:143165	18/79 (23%)
		I-set	468..559	CDD:254352	26/117 (22%)
		IGc2	484..549	CDD:197706	18/82 (22%)
		PTK_CCK4	686..1026	CDD:133178	24/130 (18%)
		STYKc	692..1020	CDD:214568	22/124 (18%)
Il1rap	NP_001152790.1	Ig1_IL1R_like	25..132	CDD:409584	27/116 (23%)
		Ig strand B	43..47	CDD:409584	0/3 (0%)
		Ig strand C	67..71	CDD:409584	1/3 (33%)
		Ig strand E	97..101	CDD:409584	2/19 (11%)
		Ig strand F	111..116	CDD:409584	2/4 (50%)
		Ig strand G	124..127	CDD:409584	0/2 (0%)
		Ig	145..235	CDD:416386	23/97 (24%)
		Ig strand A	145..150	CDD:409353	2/5 (40%)
		Ig strand A	145..150	CDD:409353	2/5 (40%)
		Ig strand B	156..160	CDD:409353	1/3 (33%)
		Ig strand B	156..160	CDD:409353	1/3 (33%)
		Ig strand C	174..179	CDD:409353	2/4 (50%)
		Ig strand C	174..179	CDD:409353	2/4 (50%)
		Ig strand C'	182..184	CDD:409353	0/1 (0%)
		Ig strand C'	182..184	CDD:409353	0/1 (0%)
		Ig strand D	189..193	CDD:409353	2/4 (50%)
		Ig strand D	189..193	CDD:409353	2/4 (50%)
		Ig strand E	195..200	CDD:409353	0/4 (0%)
		Ig strand E	195..200	CDD:409353	0/4 (0%)
		Ig strand F	209..218	CDD:409353	5/8 (63%)
		Ig strand F	209..218	CDD:409353	5/8 (63%)
		Ig strand G	221..234	CDD:409353	2/12 (17%)
		Ig strand G	221..234	CDD:409353	2/12 (17%)
		Ig3_IL1RAP	243..349	CDD:409525	23/111 (21%)
		Ig strand B	262..266	CDD:409525	1/3 (33%)
		Ig strand C	279..283	CDD:409525	0/3 (0%)
		Ig strand E	314..318	CDD:409525	1/3 (33%)
		Ig strand F	329..334	CDD:409525	2/4 (50%)
		Ig strand G	341..344	CDD:409525	0/2 (0%)
		TIR	404..547	CDD:214587	25/162 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910