DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment otk and Il18rap

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_034683.1	Gene:	Il18rap / 16174	MGIID:	1338888	Length:	614	Species:	Mus musculus

Alignment Length:	412	Identity:	85/412 - (20%)
Similarity:	142/412 - (34%)	Gaps:	125/412 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   312 PGHSFDSG--KD-------------ALLREDARLVLHKQN-GTLSFASIIASDAGQYQCQLQLEA 360
            |.|...||  ||             :.|.|.:|...|.|: |.|...:...:....|.|:
Mouse    68 PAHKPCSGSQKDLSDVQWYMQPRSGSPLEEISRNSPHMQSEGMLHILAPQTNSIWSYICR----- 127

  Fly   361 HAPINSSP--------GILEVIEQLKFVPQPTSKNLE--LDAVVAKVHCKA----QGTPTPQVQW 411
              |...||        .:|||..|.......|:::.:  |......:||.:    ....:|::.|
Mouse   128 --PRIRSPQDMACCIKTVLEVKPQRNVSCGNTAQDEQVLLLGSTGSIHCPSLSCQSDVQSPEMTW 190

  Fly   412 VRDGENTTLPDHVE--VDANGTLIFRNVNSEHRGNYTCLATNSQG----QINATVAINVV----- 465
            .:||.  .||:|.:  ::.....:|      ::|.|.|..|.|..    .:.|.|.:..:
Mouse   191 YKDGR--LLPEHKKNPIEMADIYVF------NQGLYVCDYTQSDNVSSWTVRAVVKVRTIGKDIN 247

  Fly   466 VTPKFSVPPVGPIETSEQGTVVMHC------QAIGDPKPTIQWDKDLKYLSENNTDRERFRFLE- 523
            |.|:...|....::......:.:.|      |.:.  ||.|:|     |:.|:..:.|...|.|
Mouse   248 VKPEILDPITDTLDVELGKPLTLPCRVQFGFQRLS--KPVIKW-----YVKESTQEWEMSVFEEK 305

  Fly   524 -----------NGTLEIRNVQVED-EGSYGCTIGNSAG--------LKREDVQLVVKTTGDGFAP 568
                       ..|:.:|.|...| ...:.|...||.|        .|:|:|..|....|
Mouse   306 RIQSTFKNEVIERTIFLREVTQRDLSRKFVCFAQNSIGNTTRTIRLRKKEEVVFVYILLG----- 365

  Fly   569 EESGGDGFLVTRAVLITMTVALAYIVLV-VGLMLWCR-YRRQARKARLND-------LSTKEAGG 624
                      |..:|:.:.||.|::... :.::|.|| |:.  :...|.|       :|......
Mouse   366 ----------TALMLVGVLVAAAFLYWYWIEVVLLCRTYKN--KDETLGDKKEFDAFVSYSNWSS 418

  Fly   625 DQPDVAGNGKGSEQEPCLSKQH 646
            .:.|..|:         ||::|
Mouse   419 PETDAVGS---------LSEEH 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352
		Ig	31..115	CDD:299845
		IGc2	133..195	CDD:197706
		Ig	268..373	CDD:299845	19/84 (23%)
		Ig	395..460	CDD:143165	16/74 (22%)
		I-set	468..559	CDD:254352	24/117 (21%)
		IGc2	484..549	CDD:197706	18/83 (22%)
		PTK_CCK4	686..1026	CDD:133178
		STYKc	692..1020	CDD:214568
Il18rap	NP_034683.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..78		4/9 (44%)
		Ig	161..243	CDD:299845	18/89 (20%)
		Ig	255..351	CDD:299845	20/102 (20%)
		IG_like	262..352	CDD:214653	19/96 (20%)
		TIR	410..558	CDD:279864	6/31 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910