DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otk and Cd22

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	XP_006539552.1	Gene:	Cd22 / 12483	MGIID:	88322	Length:	879	Species:	Mus musculus

Alignment Length:	838	Identity:	166/838 - (19%)
Similarity:	274/838 - (32%)	Gaps:	289/838 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SSSRFQRVPQSQSVV-ENESVKFECESTDSYSELHYD----W-LHNGHRIAYDKRVHQIGS---- 77
            |...||...|..|.: |::||...|..  ::|...||    | |.:....:....|..|.|
Mouse   158 SEKPFQPYIQMPSEIRESQSVTLTCGL--NFSCFGYDILLKWFLEDSEITSITSSVTSITSSVTS 220

  Fly    78 ---NLHIEA----VRRTEDVGNYV-CIATNLASGAREASPPAKLSVIYLESASVQLLGS---NRN 131
               |::.|:    ..:..|.|..| |...:.:....|.:  .:|.|.|.....:::..:   ..|
Mouse   221 SIKNVYTESKLTFQPKWTDHGKSVKCQVQHSSKVLSERT--VRLDVKYTPKLEIKVNPTEVEKNN 283

  Fly   132 ELLLKCHVEGASGDLEPLEIEWYRNSEKLSTWKNVQLDQH----RLIIRQPGSEDDGLYRCTASN 192
            .:.:.|.|..::..|..:.:.|:::...|   ::.:|:|.    :||:.....:..|.|||.|||
Mouse   284 SVTMTCRVNSSNPKLRTVAVSWFKDGRPL---EDQELEQEQQMSKLILHSVTKDMRGKYRCQASN 345

  Fly   193 AAGRVMSKQ----------------------------------------GYVYQSSVKCLP---- 213
            ..|...|::                                        .|.:..:.|.:|
Mouse   346 DIGPGESEEVELTVHYAPEPSRVHIYPSPAEEGQSVELICESLASPSATNYTWYHNRKPIPGDTQ 410

  Fly   214 ---RLPRRKNEKMMESWDKQTFLC-------RGKRGGAAGLEALPAAPEDLRIVQG--PIGQSII 266
               |:|:      :..|....:.|       .||....|.|:...|......::|.  |     |
Mouse   411 EKLRIPK------VSPWHAGNYSCLAENRLGHGKIDQEAKLDVHYAPKAVTTVIQSFTP-----I 464

  Fly   267 KEGEPTALTCLYEL--PDELKNQRIQLRWRKDGKLLRQVELGGSAPIPGHSFDSGKDALLREDAR 329
            .||:...|.|.|..  ||.     ...||...|        .||...||
Mouse   465 LEGDSVTLVCRYNSSNPDV-----TSYRWNPQG--------SGSVLKPG---------------- 500

  Fly   330 LVLHKQNGTLSFASIIASDAGQYQCQLQLEAHAPINSSPGILEVIEQLKFVPQPTSKNLELDAVV 394
             ||..|..|.. :..::..|..::|...|         |.||.|    .:.|:        |..|
Mouse   501 -VLRIQKVTWD-SMPVSCAACNHKCSWAL---------PVILNV----HYAPR--------DVKV 542

  Fly   395 AKVHCKAQGTPTPQVQWVRDGENTTLP-DHVEVD---------ANGTLI-------FRNVNSEHR 442
            .||      :|..:   :|.|:...|. |..|.:         .||:|:       |.:|:.|..
Mouse   543 LKV------SPASE---IRAGQRVLLQCDFAESNPAEVRFFWKKNGSLVQEGRYLSFGSVSPEDS 598

  Fly   443 GNYTCLATNSQGQ-INATVAINVVVTP---KFSVPPVGPIETSEQGTVVMHCQAIGDPKPTIQWD 503
            |||.|:..||.|: ::....:.|:..|   :.|:.|...:...::.|  :.|::..:| |..|:
Mouse   599 GNYNCMVNNSIGETLSQAWNLQVLYAPRRLRVSISPGDHVMEGKKAT--LSCESDANP-PISQY- 659

  Fly   504 KDLKYLSENNTDRERFRFLENGTLEIRNVQVEDEGSYGCTIGNSAGLKREDVQLVVKTTGDG--- 565
               .:...:..|...    ....|.:..::|:..|||.|...|..|            ||:.
Mouse   660 ---TWFDSSGQDLHS----SGQKLRLEPLEVQHTGSYRCKGTNGIG------------TGESPPS 705

  Fly   566 -----FAPEESG-----GDGFLVTRAVLITMTVALAYIVLVVGLML---WCRYRRQA-------- 609
                 ::||..|     |.||.:|..:|           .:.|:.:   |.:.|.|.
Mouse   706 TLTVYYSPETIGKRVALGLGFCLTICIL-----------AIWGMKIQKKWKQNRSQQGLQENSSG 759

  Fly   610 -------RKARLNDLSTKEAGGDQPDVAGNGKGSEQEPCL-----------------SKQHN-GH 649
                   :|||...||               :|.:.:.|.                 |..|| |.
Mouse   760 QSFFVRNKKARRTPLS---------------EGPQSQGCYNPAMDDTVSYAILRFPESDTHNTGD 809

  Fly   650 SKSRSKSSGDAQKSDDTACSQQSRASKKSAHIYEQL--ALPRS---GLSELIQIGRGE 702
            :.:.:..:.....||...   .|...|:....||.:  :.|..   ..|||:|.|.|:
Mouse   810 AGTPATQAPPPNNSDSVT---YSVIQKRPMGDYENVNPSCPEDESIHYSELVQFGAGK 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352	24/106 (23%)
		Ig	31..115	CDD:299845	22/101 (22%)
		IGc2	133..195	CDD:197706	16/65 (25%)
		Ig	268..373	CDD:299845	24/106 (23%)
		Ig	395..460	CDD:143165	21/82 (26%)
		I-set	468..559	CDD:254352	17/93 (18%)
		IGc2	484..549	CDD:197706	13/64 (20%)
		PTK_CCK4	686..1026	CDD:133178	7/20 (35%)
		STYKc	692..1020	CDD:214568	6/11 (55%)
Cd22	XP_006539552.1	Ig	37..145	CDD:386229
		Ig	164..250	CDD:386229	20/87 (23%)
		Ig_3	271..345	CDD:372822	15/76 (20%)
		IGc2	377..435	CDD:197706	7/63 (11%)
		IGc2	554..610	CDD:197706	16/55 (29%)
		Ig_3	629..695	CDD:372822	14/76 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900