DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment otk and vsig10l

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	XP_009290965.1	Gene:	vsig10l / 100333975	ZFINID:	ZDB-GENE-131127-231	Length:	680	Species:	Danio rerio

Alignment Length:	346	Identity:	77/346 - (22%)
Similarity:	135/346 - (39%)	Gaps:	72/346 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 GKLLRQVELGGSAPIPGHSFDSGKDALLREDARLVLHKQNGTLSFASIIASDAGQYQCQLQLEAH 361
            ||||......|.:.:|    |:....|..|        |:|:|:|.::.....|.|..::.....
Zfish    68 GKLLVAKWTVGESSLP----DAASGVLKAE--------QDGSLTFRNVSMIYNGTYTVEMNKIGE 120

  Fly   362 APINSSPGILEVIEQLKFVPQPTSKNLELDAVVAKV-----HCKAQGTPTPQVQWVRDGENTTLP 421
            |.::::..:. :.:.:..|...|..:   ||:..:|     :...|| ...:|||:.:|......
Zfish   121 AKVSATFDLF-IYDLIMNVSLHTDSD---DAIEGEVKFSLYYSTIQG-EAKEVQWLFNGLQIKDG 180

  Fly   422 DHVEVDANGTLIFRNVNSEHRGNYTCLATNSQGQINATVAINVVVTPKFSVPPVGPIE----TSE 482
            .|..:... .|..:..:....|.||.|.||.....:....|.|:..|...:..|.|.:    :.|
Zfish   181 SHYSISGK-RLTIKQPSRNDTGRYTVLLTNPFSSEDHHRNITVLYGPDMPLLKVSPTKAVFVSGE 244

  Fly   483 QGTVVMHCQAIGDPKPTIQWDKDLKYLSENNTDRERFRFLENGTLEIRNVQVEDEGSYGCTIGNS 547
              ::.:.|||.|:|.|:..|          ..:.|.......||:.:.:|:....|.|.|.:.||
Zfish   245 --SLFLSCQADGEPAPSNTW----------TFNGESIPAFSPGTVSLTDVKTNQSGVYTCLMINS 297

  Fly   548 ---AGLKREDVQLVVKTTGDGFAPEES-----GGDGFLVTRAVLITMTVALAYIVLVVGLMLWCR 604
               |.|:| ::.::|..:..| ||:.|     ||              .||.::         |.
Zfish   298 RTNAALQR-NITVIVYESPSG-APQCSVQTVPGG--------------AALQFL---------CV 337

  Fly   605 YRRQARKARLNDLSTKEAGGD 625
            :...|..||::..|..:|||:
Zfish   338 WPGGAPAARVSFPSLSDAGGE 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352
		Ig	31..115	CDD:299845
		IGc2	133..195	CDD:197706
		Ig	268..373	CDD:299845	16/75 (21%)
		Ig	395..460	CDD:143165	15/69 (22%)
		I-set	468..559	CDD:254352	23/97 (24%)
		IGc2	484..549	CDD:197706	16/67 (24%)
		PTK_CCK4	686..1026	CDD:133178
		STYKc	692..1020	CDD:214568
vsig10l	XP_009290965.1	Ig	46..131	CDD:299845	16/75 (21%)
		Ig	167..223	CDD:299845	13/56 (23%)
		IG_like	235..311	CDD:214653	21/88 (24%)
		IGc2	242..293	CDD:197706	14/62 (23%)
		Ig	413..478	CDD:299845
		FN3	496..583	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900