DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otk and ptk7b

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	XP_021336598.1	Gene:	ptk7b / 100150035	ZFINID:	ZDB-GENE-101124-3	Length:	414	Species:	Danio rerio

Alignment Length:	486	Identity:	141/486 - (29%)
Similarity:	238/486 - (48%)	Gaps:	113/486 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   555 VQLVVKTTGDGFAPEESGGD--GFLVTRAVLITMTVALAYIVLVVGLMLWCRYRRQARKARLNDL 617
            |::.|..:.:..||.:...|  .|.:.:.|.:::.||:||::.::|||.:|:.||::|..:....
Zfish    23 VRVCVCVSSEKPAPRDEDEDKSQFKLFQTVALSVAVAVAYMMAMLGLMFYCKQRRRSRHTQKTHT 87

  Fly   618 STKEAGGDQPDVAGNGKGSEQEPCLSKQHNGH---------SKSRSKSSGDAQKSDDTACSQQSR 673
            :.:               :|.| ||:...|||         :.:..::|.|.:|  :.:||...:
Zfish    88 AAE---------------AETE-CLNVPLNGHRVAGLQEEVALTDLRASADPEK--EQSCSDTHQ 134

  Fly   674 ASKKSAHIYEQLALPRSGLSELIQIGRGEFGDVFVGKLKATLVTSPSDKDADTEKQHSNSENGSG 738
                         .||:.|..:..:|||.||:||:.|.:|.|.:
Zfish   135 -------------FPRAHLQHITTLGRGVFGEVFLAKARALLAS--------------------- 165

  Fly   739 GSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSGLEQLVLVKALNKVKDEQAC--QEFR 801
                                          |||         .|||||:|   :..:.|  :||.
Zfish   166 ------------------------------EEQ---------TLVLVKSL---QSSEVCAQREFS 188

  Fly   802 RQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFLLATAGKVNTATAGSSSPPPLTT 866
            |::.:...:.|..:.||.|:|.|..|.||:|||.|.|||||||     ::.::::.|||..|::|
Zfish   189 REMQMFSKLQHTHITRLLGVCTETQPLYMMLEYEDLGDLKQFL-----QIQSSSSSSSSTHPIST 248

  Fly   867 SQVLAVAYQIARGMDAIYRARFTHRDLATRNCVISSEFIVKVSYPALCKDKYSREYHKHRNTLLP 931
            ...:::..|:|.||..:.:..|.|.|:|.|||:||.:..||||..:|.:|.|..||::|....:|
Zfish   249 RTKISICAQVADGMQYLSQQGFVHGDVAARNCLISGQRHVKVSALSLSQDVYKSEYYQHGQLWIP 313

  Fly   932 IRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQATKLPHEELTNEQVVQRSQAGSLEWSVAEATP 996
            :|||..||:...|:::|||::|:.|::||:|:.| .||:..|::|||::..:.|.|........|
Zfish   314 LRWLPLECVLHREFSSKSDVWAFAVLMWEVFSLA-DLPYTHLSDEQVLEGLRGGVLRLPPPAGCP 377

  Fly   997 DSLREILLSCWVSNPKERPSFSQLGAALSKA 1027
            ..|..::..|..|:|||||:||::...|:.|
Zfish   378 APLFSLMRRCCSSSPKERPAFSEILQTLTDA 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352
		Ig	31..115	CDD:299845
		IGc2	133..195	CDD:197706
		Ig	268..373	CDD:299845
		Ig	395..460	CDD:143165
		I-set	468..559	CDD:254352	1/3 (33%)
		IGc2	484..549	CDD:197706
		PTK_CCK4	686..1026	CDD:133178	110/341 (32%)
		STYKc	692..1020	CDD:214568	107/329 (33%)
ptk7b	XP_021336598.1	PKc_like	135..407	CDD:328722	110/340 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H43672
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245153at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010