DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment otk and zgc:172106

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_001108035.2	Gene:	zgc:172106 / 100136844	ZFINID:	ZDB-GENE-080204-42	Length:	396	Species:	Danio rerio

Alignment Length:	465	Identity:	101/465 - (21%)
Similarity:	163/465 - (35%)	Gaps:	163/465 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 AKLSVIYLESASVQLLGSNRNELLLKCHVEGASGDLEPLEIEWYRNSEKLSTWKNVQLDQHRLII 175
            :|.::..|:.::::|.||.:       |.:|    |...||.|..|.||   .|.:.|      :
Zfish    26 SKTAICVLKGSTMRLSGSYK-------HPDG----LTVTEIFWTVNIEK---GKAINL------L 70

  Fly   176 RQPGSEDDGLYRCTASNAAGRV----MSKQGYVYQSSVKCLPRLPRRKNEKMM-----ESWDKQT 231
            ..|             |..|||    :.:..::..|:|       |.::|.|.     ...:||.
Zfish    71 NNP-------------NYTGRVDYFQIEEMFFLKLSNV-------RHEDEGMYCIRIETKVEKQQ 115

  Fly   232 FLCRGKRGGAAGLEALPAAPEDLRIVQGPIGQSIIKEGEPTALTCLYELPDELKNQRIQLR---- 292
            ||      |..|:|   ....||| |:.|   :.:.||:...|||         .....|.
Zfish   116 FL------GFPGIE---LTVTDLR-VETP---AEVVEGDSPVLTC---------KSSCNLGSTIF 158

  Fly   293 -WRKDGKLLRQVELGGSAPIPGHSFDSGKDALLREDARLVLHKQNGTLSFASIIASDAGQYQCQL 356
             |.|:||                ||.        |..|     || .|...|:.:.|:|.|.|.:
Zfish   159 IWYKNGK----------------SFS--------ESVR-----QN-QLILQSVSSEDSGNYSCAV 193

  Fly   357 QLEAHAPINSSPGILEVIEQLKFVPQPTSKNLELDAVV-----AKVHCKAQGTPTPQVQ--WVRD 414
            :.....|   ||.:   ...:::.|:..|.::...||:     ..:.|.:...| |.|.  |.::
Zfish   194 RDLKDLP---SPAL---TLNIRYPPKSVSVSVSGSAVIESGDSVTLSCSSDSNP-PAVNFTWFKE 251

  Fly   415 GENTTLPDHVEVDANGTLIFRNVNSEHRGNYTCLATNSQG-QINATVAINVVVTPKFSVPPVGPI 478
            .:::.      |.:..:....:.||.|.|.|.|.|.|..| |.:.:|::.|..:..|.:.....|
Zfish   252 NQSSA------VGSGQSFSISSFNSSHSGQYYCEAENKYGSQRSESVSVTVKESGSFWISITAGI 310

  Fly   479 ---------------------ETSEQGTVVMHCQ---AIGDPK-PTIQWD-----------KDLK 507
                                 |.:.:|:.....|   |:..|: |.:..|           .:||
Zfish   311 AASAFVFVFIVIIRKRVTRSEEQNHRGSQQQQQQKHSAVEPPEDPYMALDPNSRCSEYDTLDNLK 375

  Fly   508 YLSENNTDRE 517
            ...||..|||
Zfish   376 RSCENTDDRE 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352	1/3 (33%)
		Ig	31..115	CDD:299845	1/3 (33%)
		IGc2	133..195	CDD:197706	13/61 (21%)
		Ig	268..373	CDD:299845	25/109 (23%)
		Ig	395..460	CDD:143165	16/67 (24%)
		I-set	468..559	CDD:254352	16/86 (19%)
		IGc2	484..549	CDD:197706	13/49 (27%)
		PTK_CCK4	686..1026	CDD:133178
		STYKc	692..1020	CDD:214568
zgc:172106	NP_001108035.2	IG_like	32..126	CDD:214653	32/142 (23%)
		Ig	32..110	CDD:299845	25/117 (21%)
		ig	131..195	CDD:278476	24/105 (23%)
		IG_like	136..195	CDD:214653	22/97 (23%)
		Ig_2	228..296	CDD:290606	17/74 (23%)
		IG_like	228..296	CDD:214653	17/74 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900