DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8298 and gk5

DIOPT Version :9

Sequence 1:	NP_610718.1	Gene:	CG8298 / 36282	FlyBaseID:	FBgn0033673	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_001071271.3	Gene:	gk5 / 777765	ZFINID:	ZDB-GENE-061110-49	Length:	529	Species:	Danio rerio

Alignment Length:	570	Identity:	150/570 - (26%)
Similarity:	261/570 - (45%)	Gaps:	75/570 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NGRYGRFGALIGVACVSSTHCRFLIYSTKNAEVLAYHELKLRQIVHQAGWMEYDPSEIWKNTQEC 67
            || |.:....|....|.:|..|..:|. |:|.:......|:..:..|.||:|.||.|:|......
Zfish     6 NG-YSKRETFILSVDVGTTSIRCHVYD-KSASIRGSCSAKVSLLYPQPGWVEIDPDELWDGFVTV 68

  Fly    68 IETAYKN--LVILEINPRDIIAIGIVNQRGTSVLWNLETGQPLHNAIGWSDCRSTPILKT----- 125
            ::.|.::  |.:.::.     ::||..||.|.:.|:..||:|.|..|.|.|.|:..::::
Zfish    69 VKGAVQDSGLQMCQME-----SLGISTQRATFMTWDRNTGKPFHKFITWQDMRAAELVRSWNGSC 128

  Fly   126 ---LLHNVRHNVDYV-RYRSGLPLS-----SCFSALKIRWLMDHVPAVATAIEENKCLFGTLDSW 181
               .:|.|...:.:: |.:..|..|     :...:|::.|.::::|.:..|:|:..|.|||:|:|
Zfish   129 TMKTVHGVMKMLHFLSRQKRFLAASLVVFTTQHVSLRLVWALNNIPQLRQAVEDGTCYFGTIDTW 193

  Fly   182 LLWNLTGGVEMGVHSTDITNAHYTSLMNVSTEQWDPKLCQFFRLPLNILPRIRSNSEIFGYVLEG 246
            ||:.||.|:   ||:||.:||..|::.:.....|...||....:||:|||:::..|..|| :.:.
Zfish   194 LLYKLTKGL---VHATDYSNASATAIFDSYQMCWSGFLCSLLSIPLSILPKVQDTSHKFG-LCDS 254

  Fly   247 PLHGTPIAAM--MGEQPASLLGQLCVKAGQNVCTLDDSCFVLLNTGREKLDSANGLITGIAHKLG 309
            .:.|.||..|  |.:|.|::.|:.|...|....|:....|:.:|||.:...|..||...:..|:|
Zfish   255 SIFGVPIPIMCVMADQQAAMFGECCFDTGDVKITMGTGTFMDINTGSKPHTSVAGLYPLVGWKIG 319

  Fly   310 EKAATNYTLEGAISNAGSTVTWLRDKLQINTEINSNDNVVESLNTFIGENSMISSSCSSSMLNAE 374
              |...|..||..:..|:.:.|.:| |::.:::...:.:..|:....|
Zfish   320 --ADVVYLAEGNAAGTGAAIKWAQD-LELFSDVKETEAIATSVEDSDG----------------- 364

  Fly   375 CGLAAKRSEITFVPAFHGMYAPYWRHDARGIILGLTSQTTAENITQAAYEATGF---QIFEVLQA 436
                     :.|||:|.|:.||.....|....:||...||..::.:|..|:..|   |:|:|:
Zfish   365 ---------VFFVPSFSGLQAPLNDPKACASFMGLKPSTTKRHLVRAILESIAFRNKQLFDVM-- 418

  Fly   437 FKRDTPNWDRSSMQPVLTFGGDYAENLHLVQFIADIIGYMLERPQTTSPAGLGVMITAGVTMKVV 501
             .|:|    |..:..:...|| ...|..::|..||::|..:.||.....:.||....||:.....
Zfish   419 -LRET----RIPITKIRADGG-VCTNDFIMQLTADLLGRKIARPSHFDMSCLGAAFVAGLGTGYW 477

  Fly   502 SLEHAVKMYTPPTDVFSPTTTKNRREL--LYK----RWAYAVKKCLHWNN 545
            ..:..:|........|.|..:|:..|.  ||:    .|..|:::.:||.|
Zfish   478 RNQEELKKLLSTDQHFLPRRSKSEGEKGGLYRGVLQSWEKALQRSMHWYN 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8298	NP_610718.1	FGGY_GK	12..534	CDD:198347	142/548 (26%)
CG8298	NP_610718.1	glycerol_kin	21..543	CDD:273549	142/548 (26%)
gk5	NP_001071271.3	GlpK	14..525	CDD:223628	144/557 (26%)
gk5	NP_001071271.3	FGGY_GK5_metazoa	14..522	CDD:212665	144/554 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820