DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8298 and Gk1

DIOPT Version :9

Sequence 1:	NP_610718.1	Gene:	CG8298 / 36282	FlyBaseID:	FBgn0033673	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_524655.1	Gene:	Gk1 / 43913	FlyBaseID:	FBgn0025592	Length:	538	Species:	Drosophila melanogaster

Alignment Length:	556	Identity:	206/556 - (37%)
Similarity:	316/556 - (56%)	Gaps:	46/556 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GALIGVACVSSTHCRFLIYSTKNAEVLAYHELKLRQIVHQAGWMEYDPSEIWKNTQECIETAYKN 74
            |..:|.....:|..||:|:.....|::.:|::::..|..:.||.|.||..|.....|||..|.|.
  Fly    17 GPFVGAIDEGTTSARFIIFRAGTDEIVCFHQIEVESIFQKEGWCEQDPMAIVNTVNECITGACKK 81

  Fly    75 LVILEINPRDIIAIGIVNQRGTSVLWNLETGQPLHNAIGWSDCRST----PILKTLLHNVRHNVD 135
            ||.:.....:||.|||.|||.::|:|:..:||||.|||.|.|.|:|    .:|:|:.:|.| |::
  Fly    82 LVAVGGKVEEIITIGITNQRESTVVWDRNSGQPLVNAIIWLDNRTTSTVEELLETIPNNAR-NIN 145

  Fly   136 YVRYRSGLPLSSCFSALKIRWLMDHVPAVATAIEENKCLFGTLDSWLLWNLTGGVEMGVHSTDIT 200
            |:|...|||||..||.:|:|||.|:||.|:.|:|:...:|||:|:||::|||||.:.|||.||:|
  Fly   146 YLRPLCGLPLSPYFSGVKLRWLRDNVPVVSQAMEKGTAMFGTIDTWLMYNLTGGKDCGVHKTDVT 210

  Fly   201 NAHYTSLMNVSTEQWDPKLCQFFRLPLNILPRIRSNSEIFGYVLEGPLHGTPIAAMMGEQPASLL 265
            ||..|.|||:.|.|||..|.:||.||..|||.|.|:||.:|.:.:|.|.|..|.:::|:|.|:|:
  Fly   211 NASRTMLMNIETLQWDANLLKFFGLPKTILPEICSSSEFYGSIAQGVLQGIGITSVLGDQQAALV 275

  Fly   266 GQLCVKAGQNVCTLDDSCFVLLNTGREKLDSANGLITGIAHKLGEKAATNYTLEGAISNAGSTVT 330
            ||.|:..||...|....||:|.|||...:.|.:||:|.:.::||.||...|.|||::|.||:...
  Fly   276 GQQCLAKGQAKATYGTGCFLLYNTGPSIVHSTHGLLTTVGYQLGRKAVPFYALEGSVSIAGAAFN 340

  Fly   331 WLRDKLQINTEINSNDNVVESLNTFIGENSMISSSCSSSMLNAECGLAAKRSEITFVPAFHGMYA 395
            ||||    |..:..|...:|::.:.: :||:                     ::.|||||:|:||
  Fly   341 WLRD----NMNLIQNSGQIETMASTV-DNSL---------------------DVYFVPAFNGLYA 379

  Fly   396 PYWRHDARGIILGLTSQTTAENITQAAYEATGFQIFEVLQAFKRDTPNWDRSSMQPVLTFGGDYA 460
            |||..||||:|.||:.:||:|:|.:|..||..||:.::|.:..:|.    :..:..::..||...
  Fly   380 PYWNQDARGVICGLSEETTSEHIVRATLEAVCFQVRDILDSMHKDC----KIPLAKLMVDGGMTV 440

  Fly   461 ENLHLVQFIADIIGYMLERPQTTSPAGLGVMITAGVTMKVVSLEHAVKMYTP-----PTDVFSPT 520
            .||.| |..:|::|..:.|.:......||..:.|     ..::|:..:|..|     |.:...|:
  Fly   441 NNLFL-QLQSDLVGIQVLRAKIAETTALGAAMAA-----YKAVENRYQMEAPLSKSGPREAIKPS 499

  Fly   521 TTKNRRELLYKRWAYAVKKCLHWNNYETYEADIELF 556
            .:...|.|.|::|..|:.:.|:|......:.:.|.|
  Fly   500 ISATDRNLRYQKWKMAIDRSLNWETSTLPQGEREAF 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8298	NP_610718.1	FGGY_GK	12..534	CDD:198347	199/530 (38%)
CG8298	NP_610718.1	glycerol_kin	21..543	CDD:273549	201/530 (38%)
Gk1	NP_524655.1	glycerol_kin	18..522	CDD:273549	202/540 (37%)
Gk1	NP_524655.1	FGGY_GK1-3_metazoa	18..522	CDD:212664	202/540 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443070
Domainoid	1	1.000	195	1.000	Domainoid score	I120
eggNOG	1	0.900	-	-		E1_COG0554
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D34936at6960
OrthoFinder	1	1.000	-	-		FOG0001035
OrthoInspector	1	1.000	-	-		otm46472
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10196
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.850