DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8298 and Gykl1

DIOPT Version :9

Sequence 1:	NP_610718.1	Gene:	CG8298 / 36282	FlyBaseID:	FBgn0033673	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_599168.1	Gene:	Gykl1 / 291468	RGDID:	1305596	Length:	549	Species:	Rattus norvegicus

Alignment Length:	590	Identity:	210/590 - (35%)
Similarity:	330/590 - (55%)	Gaps:	59/590 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GALIGVACVSSTHCRFLIYSTKNAEVLAYHELKLRQIVHQAGWMEYDPSEIWKNTQECIETAYKN 74
            |.|:|.....::..|||:::.:.||:|.:|::::.|...:.||:|.||..|.::..||||...:.
  Rat    10 GPLVGAVDQGTSSTRFLVFNPQTAELLCHHQVEIAQEFPREGWVEQDPKVILQSVYECIEKTCEK 74

  Fly    75 LVILEINPRDIIAIGIVNQRGTSVLWNLETGQPLHNAIGWSDCRSTPILKTLLHNVRHNVDYVRY 139
            |....|:..:|.|||:.|||.|:::|:..||:||:||:.|.|.|:...::.|..::..:.::::.
  Rat    75 LGQQSIDISNIKAIGVTNQRETTIVWDKFTGEPLYNAVVWLDLRTQSTVENLNKSISASNNFIKI 139

  Fly   140 RSGLPLSSCFSALKIRWLMDHVPAVATAIEENKCLFGTLDSWLLWNLTGGVEMGVHSTDITNAHY 204
            ::|||:|:.|||:|:.||:::|..|..|||:.:..|||:||||:|.:|||:..|||.||::||..
  Rat   140 KTGLPISTYFSAVKLHWLIENVKNVQKAIEDGRAFFGTVDSWLIWCMTGGINGGVHCTDVSNASR 204

  Fly   205 TSLMNVSTEQWDPKLCQFFRLPLNILPRIRSNSEIFGYVLEGPLHGTPIAAMMGEQPASLLGQLC 269
            |.|.|:.:.|||.:||:||.:|:.|||||||:|||:|.:..|.|.|.||:..:|:|.|:|:||||
  Rat   205 TMLFNIHSLQWDEELCEFFGIPMTILPRIRSSSEIYGLMKSGVLEGVPISGCLGDQSAALVGQLC 269

  Fly   270 VKAGQNVCTLDDSCFVLLNTGREKLDSANGLITGIAHKLGEKAATNYTLEGAISNAGSTVTWLRD 334
            ::.||...|....||:|.|||::.::|.:||:|.:|:|:|.:....|.|||:::.||:.|:||::
  Rat   270 LQDGQAKSTYGTGCFLLCNTGQKCVNSDHGLLTTVAYKMGREEPVYYALEGSVAIAGAVVSWLKN 334

  Fly   335 KLQINTEINSNDNVVESLNTFIGENSMISSSCSSSMLNAECGLAAKRSEITFVPAFHGMYAPYWR 399
            .|||   |.|:.::.:     :.|.:..|..|                  .|||||.|:|||||.
  Rat   335 NLQI---IKSSSDIEK-----LAEKAGTSYGC------------------YFVPAFSGLYAPYWD 373

  Fly   400 HDARGIILGLTSQTTAENITQAAYEATGFQIFEVLQAFKRDTPNWDRSSMQPVLTFGGDYAENLH 464
            ..|||||.|||..|...:|..||.||..||..|:|     |..|.|.......|...|....|..
  Rat   374 PSARGIICGLTQFTNKFHIAFAALEAVCFQTREIL-----DAMNSDCGIPLTHLQVDGGMTANKI 433

  Fly   465 LVQFIADIIGYMLERPQTTSPAGLGVMITAGVT--MKVVSLEHAVKMYTPPTDV-------FSPT 520
            |:|..|||:...:.:|.......||..:.||..  ::|.||:        |.|:       |.|.
  Rat   434 LMQLQADILCIPVMKPFMPETTALGAAMAAGAAEGIRVWSLD--------PKDLTGVQMEKFEPQ 490

  Fly   521 TTKNRRELLYKRWAYAVKKCLHWNNYETYEADIELFAQRELDPNLPVRRSVPGSIFLTTSFAMII 585
            ......|..|..|..||.|.:.|...::.:..         ||:  :.||:....::.:|..::|
  Rat   491 INVEESEGRYSTWKRAVMKSMGWVLTQSPDGH---------DPS--IFRSLTLGFYIVSSMVLLI 544

  Fly   586 LANYL 590
            .|.|:
  Rat   545 GARYI 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8298	NP_610718.1	FGGY_GK	12..534	CDD:198347	196/530 (37%)
CG8298	NP_610718.1	glycerol_kin	21..543	CDD:273549	198/530 (37%)
Gykl1	NP_599168.1	glycerol_kin	11..513	CDD:273549	200/540 (37%)
Gykl1	NP_599168.1	FGGY_GK1-3_metazoa	11..513	CDD:212664	200/540 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337242
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	1	1.000	-	-		FOG0001035
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10196
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.810