Protein Alignment CG8298 and GK3

DIOPT Version :10

• Sequence 1: NP_610718.1
• Gene: CG8298 / 36282
• FlyBaseID: FBgn0033673
• Length: 596
• Species: Drosophila melanogaster
• Sequence 2: NP_001382882.1
• Gene: GK3 / 2713
• HGNCID: 4292
• Length: 553
• Species: Homo sapiens
• Alignment Length: 602
• Identity: 230/602 - (38%)
• Similarity: 337/602 - (55%)
• Gaps: 57/602 - (9%)

  Fly     1 MSNGRYGRFGALIGVACVSSTHCRFLIYSTKNAEVLAYHELKLRQIVHQAGWMEYDPSEIWKNTQ 65
            |:..:....|.|:|.....::..|||:::::.||:|::|:::::|...:.||:|.||.||..:..
Human     1 MAASKKAVLGPLVGAVDQGTSSTRFLVFNSRTAELLSHHQVEIKQEFPREGWVEQDPKEILHSVY 65

  Fly    66 ECIETAYKNLVILEINPRDIIAIGIVNQRGTSVLWNLETGQPLHNAIGWSDCRSTPILKTLLHNV 130
            ||||...:.|..|.|...:|.|||:.|||.|:|:|:..||:||:||:.|.|.|:...:::|...:
Human    66 ECIEKTCEKLGQLNIGISNIKAIGVSNQRETTVVWDKITGEPLYNAVVWLDLRTQSTVESLSKRI 130

  Fly   131 RHNVDYVRYRSGLPLSSCFSALKIRWLMDHVPAVATAIEENKCLFGTLDSWLLWNLTGGVEMGVH 195
            ..|.::|:.::|||||:.|||:|:|||:|:|..|..|:||.:.||||:||||:|:|||||..|||
Human   131 PGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEKRALFGTIDSWLIWSLTGGVNGGVH 195

  Fly   196 STDITNAHYTSLMNVSTEQWDPKLCQFFRLPLNILPRIRSNSEIFGYVLEGPLHGTPIAAMMGEQ 260
            .||:|||..|.|.|:.:.:||.:||:||.:|:.|||.:||:|||:|.:..|.|.|.||:..:|:|
Human   196 CTDVTNASRTMLFNIHSLEWDKQLCEFFGIPMEILPHVRSSSEIYGLMKAGALEGVPISGCLGDQ 260

  Fly   261 PASLLGQLCVKAGQNVCTLDDSCFVLLNTGREKLDSANGLITGIAHKLGEKAATNYTLEGAISNA 325
            .|:|:||:|.:.||...|....||:|.|||.:.:.|.:||:|.:|:|||......|.|||:::.|
Human   261 SAALVGQMCFQIGQAKNTYGTGCFLLCNTGHKCVFSDHGLLTTVAYKLGRDKPVYYALEGSVAIA 325

  Fly   326 GSTVTWLRDKLQINTEINSNDNVVESLNTFIGENSMISSSCSSSMLNAECGLAAKRSEITFVPAF 390
            |:.:.||||.|.|   |.:::. :|.|...:|    .|..|                  .|||||
Human   326 GAVIRWLRDNLGI---IKTSEE-IEKLAKEVG----TSYGC------------------YFVPAF 364

  Fly   391 HGMYAPYWRHDARGIILGLTSQTTAENITQAAYEATGFQIFEVLQAFKRDTPNWDRSSMQPV--L 453
            .|:|||||...|||||.|||..|...:|..||.||..||..|:|.|..||..       .|:  |
Human   365 SGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCG-------IPLSHL 422

  Fly   454 TFGGDYAENLHLVQFIADIIGYMLERPQTTSPAGLGVMITAGVT--MKVVSLE----HAVKMYTP 512
            ...|....|..|:|..|||:...:.:|.......||..:.||..  :.|.|||    .||.|
Human   423 QVDGGMTSNKILMQLQADILYIPVVKPLMPETTALGAAMAAGAAEGVDVWSLEPEDLSAVTM--- 484

  Fly   513 PTDVFSPTTTKNRRELLYKRWAYAVKKCLHWNNYETYEADIELFAQRELDPNLPVRRSVPGSIFL 577
              :.|.|.......|:.|..|..||.|.:.|...::.|..         ||:  |..|:|...|:
Human   485 --ERFEPQINAEESEIRYSTWKKAVMKSMGWVTTQSPEGG---------DPS--VFCSLPLGFFI 536

  Fly   578 TTSFAMIILANYLKSNP 594
            .:|.||:|.|.|:...|
Human   537 VSSMAMLIGARYISGIP 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8298	NP_610718.1	ASKHA_ATPase-like	19..540	CDD:483947	210/528 (40%)
GK3	NP_001382882.1	ASKHA_NBD_FGGY_GK1-3-like	11..510	CDD:466802	212/536 (40%)