Protein Alignment CG8298 and GK2

DIOPT Version :10

• Sequence 1: NP_610718.1
• Gene: CG8298 / 36282
• FlyBaseID: FBgn0033673
• Length: 596
• Species: Drosophila melanogaster
• Sequence 2: NP_149991.2
• Gene: GK2 / 2712
• HGNCID: 4291
• Length: 553
• Species: Homo sapiens
• Alignment Length: 593
• Identity: 219/593 - (36%)
• Similarity: 329/593 - (55%)
• Gaps: 57/593 - (9%)

  Fly    10 GALIGVACVSSTHCRFLIYSTKNAEVLAYHELKLRQIVHQAGWMEYDPSEIWKNTQECIETAYKN 74
            |.|:|.....:...|||::::|.||:|::|:::|.|...:.||:|.||.||.::..|||....:.
Human    10 GPLVGAVVQGTNSTRFLVFNSKTAELLSHHKVELTQEFPKEGWVEQDPKEILQSVYECIARTCEK 74

  Fly    75 LVILEINPRDIIAIGIVNQRGTSVLWNLETGQPLHNAIGWSDCRSTPILKTLLHNVRHNVDYVRY 139
            |..|.|:..:|.|:|:.|||.|:|:|:..||:||:||:.|.|.|:...::.|...:..|.::|:.
Human    75 LDELNIDISNIKAVGVSNQRETTVIWDKLTGEPLYNAVVWLDLRTQTTVEDLSKKIPGNSNFVKS 139

  Fly   140 RSGLPLSSCFSALKIRWLMDHVPAVATAIEENKCLFGTLDSWLLWNLTGGVEMGVHSTDITNAHY 204
            ::|||||:.|||:|:||::|:|..|..|:||.:.||||:||||:|:|||||..|||.||:|||..
Human   140 KTGLPLSTYFSAVKLRWMLDNVRNVQKAVEEGRALFGTIDSWLIWSLTGGVNGGVHCTDVTNASR 204

  Fly   205 TSLMNVSTEQWDPKLCQFFRLPLNILPRIRSNSEIFGYVLEGPLHGTPIAAMMGEQPASLLGQLC 269
            |.|.|:.:.:||.:||.||.:|:::||.:.|:|||:|.:..|.|.|.||:..:|:|.|:|:||:|
Human   205 TMLFNIHSLEWDKELCDFFEIPMDLLPNVFSSSEIYGLIKTGALEGVPISGCLGDQCAALVGQMC 269

  Fly   270 VKAGQNVCTLDDSCFVLLNTGREKLDSANGLITGIAHKLGEKAATNYTLEGAISNAGSTVTWLRD 334
            .:.||...|....||:|.||||:.:.|.:||:|.:|:|||.:....|.|||:::.||:.:.||||
Human   270 FQEGQAKNTYGTGCFLLCNTGRKCVFSEHGLLTTVAYKLGREKPAYYALEGSVAIAGAVIRWLRD 334

  Fly   335 KLQINTEINSNDNVVESLNTFIGENSMISSSCSSSMLNAECGLAAKRSEITFVPAFHGMYAPYWR 399
            .|.|.......:.:.:.:.|..|                 |         .|||||.|:|||||.
Human   335 NLGIIETSGDIERLAKEVGTSYG-----------------C---------YFVPAFSGLYAPYWE 373

  Fly   400 HDARGIILGLTSQTTAENITQAAYEATGFQIFEVLQAFKRDTPNWDRSSMQPV--LTFGGDYAEN 462
            ..||||:.|||..|...:|..||.||..||..|:|:|..||..       .|:  |...|....|
Human   374 PSARGILCGLTQFTNKCHIAFAALEAVCFQTREILEAMNRDCG-------IPLRHLQVDGGMTNN 431

  Fly   463 LHLVQFIADIIGYMLERPQTTSPAGLGVMITAGVT--MKVVSLE----HAVKMYTPPTDVFSPTT 521
            ..|:|..|||:...:.:|.......||..:.||..  :.|.|||    ..::|     :.|.|..
Human   432 KVLMQLQADILHIPVIKPFMPETTALGAAMAAGAAEGVSVWSLEPQALSVLRM-----ERFEPQI 491

  Fly   522 TKNRRELLYKRWAYAVKKCLHWNNYETYEADIELFAQRELDPNLPVRRSVPGSIFLTTSFAMIIL 586
            .....|:.|..|..||.|.:.|...::.|..         ||:  :..|:|...|:.:|..|:|.
Human   492 QATESEIRYATWKKAVMKSMGWVTSQSPEGG---------DPS--IFSSLPLGFFIVSSMVMLIG 545

  Fly   587 ANYLKSNP 594
            |.|:...|
Human   546 ARYISGVP 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8298	NP_610718.1	ASKHA_ATPase-like	19..540	CDD:483947	202/528 (38%)
GK2	NP_149991.2	ASKHA_NBD_FGGY_GK1-3-like	11..510	CDD:466802	204/536 (38%)