DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8298 and GK2

DIOPT Version :9

Sequence 1:	NP_610718.1	Gene:	CG8298 / 36282	FlyBaseID:	FBgn0033673	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_149991.2	Gene:	GK2 / 2712	HGNCID:	4291	Length:	553	Species:	Homo sapiens

Alignment Length:	593	Identity:	219/593 - (36%)
Similarity:	329/593 - (55%)	Gaps:	57/593 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GALIGVACVSSTHCRFLIYSTKNAEVLAYHELKLRQIVHQAGWMEYDPSEIWKNTQECIETAYKN 74
            |.|:|.....:...|||::::|.||:|::|:::|.|...:.||:|.||.||.::..|||....:.
Human    10 GPLVGAVVQGTNSTRFLVFNSKTAELLSHHKVELTQEFPKEGWVEQDPKEILQSVYECIARTCEK 74

  Fly    75 LVILEINPRDIIAIGIVNQRGTSVLWNLETGQPLHNAIGWSDCRSTPILKTLLHNVRHNVDYVRY 139
            |..|.|:..:|.|:|:.|||.|:|:|:..||:||:||:.|.|.|:...::.|...:..|.::|:.
Human    75 LDELNIDISNIKAVGVSNQRETTVIWDKLTGEPLYNAVVWLDLRTQTTVEDLSKKIPGNSNFVKS 139

  Fly   140 RSGLPLSSCFSALKIRWLMDHVPAVATAIEENKCLFGTLDSWLLWNLTGGVEMGVHSTDITNAHY 204
            ::|||||:.|||:|:||::|:|..|..|:||.:.||||:||||:|:|||||..|||.||:|||..
Human   140 KTGLPLSTYFSAVKLRWMLDNVRNVQKAVEEGRALFGTIDSWLIWSLTGGVNGGVHCTDVTNASR 204

  Fly   205 TSLMNVSTEQWDPKLCQFFRLPLNILPRIRSNSEIFGYVLEGPLHGTPIAAMMGEQPASLLGQLC 269
            |.|.|:.:.:||.:||.||.:|:::||.:.|:|||:|.:..|.|.|.||:..:|:|.|:|:||:|
Human   205 TMLFNIHSLEWDKELCDFFEIPMDLLPNVFSSSEIYGLIKTGALEGVPISGCLGDQCAALVGQMC 269

  Fly   270 VKAGQNVCTLDDSCFVLLNTGREKLDSANGLITGIAHKLGEKAATNYTLEGAISNAGSTVTWLRD 334
            .:.||...|....||:|.||||:.:.|.:||:|.:|:|||.:....|.|||:::.||:.:.||||
Human   270 FQEGQAKNTYGTGCFLLCNTGRKCVFSEHGLLTTVAYKLGREKPAYYALEGSVAIAGAVIRWLRD 334

  Fly   335 KLQINTEINSNDNVVESLNTFIGENSMISSSCSSSMLNAECGLAAKRSEITFVPAFHGMYAPYWR 399
            .|.|.......:.:.:.:.|..|                 |         .|||||.|:|||||.
Human   335 NLGIIETSGDIERLAKEVGTSYG-----------------C---------YFVPAFSGLYAPYWE 373

  Fly   400 HDARGIILGLTSQTTAENITQAAYEATGFQIFEVLQAFKRDTPNWDRSSMQPV--LTFGGDYAEN 462
            ..||||:.|||..|...:|..||.||..||..|:|:|..||..       .|:  |...|....|
Human   374 PSARGILCGLTQFTNKCHIAFAALEAVCFQTREILEAMNRDCG-------IPLRHLQVDGGMTNN 431

  Fly   463 LHLVQFIADIIGYMLERPQTTSPAGLGVMITAGVT--MKVVSLE----HAVKMYTPPTDVFSPTT 521
            ..|:|..|||:...:.:|.......||..:.||..  :.|.|||    ..::|     :.|.|..
Human   432 KVLMQLQADILHIPVIKPFMPETTALGAAMAAGAAEGVSVWSLEPQALSVLRM-----ERFEPQI 491

  Fly   522 TKNRRELLYKRWAYAVKKCLHWNNYETYEADIELFAQRELDPNLPVRRSVPGSIFLTTSFAMIIL 586
            .....|:.|..|..||.|.:.|...::.|..         ||:  :..|:|...|:.:|..|:|.
Human   492 QATESEIRYATWKKAVMKSMGWVTSQSPEGG---------DPS--IFSSLPLGFFIVSSMVMLIG 545

  Fly   587 ANYLKSNP 594
            |.|:...|
Human   546 ARYISGVP 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8298	NP_610718.1	FGGY_GK	12..534	CDD:198347	201/529 (38%)
CG8298	NP_610718.1	glycerol_kin	21..543	CDD:273549	203/529 (38%)
GK2	NP_149991.2	FGGY_GK1-3_metazoa	11..513	CDD:212664	205/539 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143497
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	1	1.000	-	-		FOG0001035
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10196
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.810