DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8298 and Gykl1

DIOPT Version :9

Sequence 1:	NP_610718.1	Gene:	CG8298 / 36282	FlyBaseID:	FBgn0033673	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_034423.2	Gene:	Gykl1 / 14625	MGIID:	891990	Length:	549	Species:	Mus musculus

Alignment Length:	588	Identity:	211/588 - (35%)
Similarity:	327/588 - (55%)	Gaps:	55/588 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GALIGVACVSSTHCRFLIYSTKNAEVLAYHELKLRQIVHQAGWMEYDPSEIWKNTQECIETAYKN 74
            |.|:|.....::..|||:::.:.||:|.:|::::.|...:.||:|.||..|.::..||||.|.:.
Mouse    10 GPLVGAVDQGTSSTRFLVFNPQTAELLCHHQVEIAQEFPKEGWVEQDPKAILQSVYECIEKACEK 74

  Fly    75 LVILEINPRDIIAIGIVNQRGTSVLWNLETGQPLHNAIGWSDCRSTPILKTLLHNVRHNVDYVRY 139
            |....|:..:|.|||:.|||.|:::|:..||:||:||:.|.|.|:...::.|..::..:.::|:.
Mouse    75 LGQQSIDISNIKAIGVTNQRETTIVWDKFTGEPLYNAVVWLDLRTQSTVENLSKSISVSNNFVKN 139

  Fly   140 RSGLPLSSCFSALKIRWLMDHVPAVATAIEENKCLFGTLDSWLLWNLTGGVEMGVHSTDITNAHY 204
            ::|||:|:.|||:|:.||:::|..|..|||:.:.:|||:||||:|.:|||:..|||.||::||..
Mouse   140 KTGLPISTYFSAVKLHWLIENVRKVQKAIEDGRAIFGTVDSWLIWCMTGGINGGVHCTDVSNASR 204

  Fly   205 TSLMNVSTEQWDPKLCQFFRLPLNILPRIRSNSEIFGYVLEGPLHGTPIAAMMGEQPASLLGQLC 269
            |.|.|:.:.|||.:||.||.:|:.|||||||:|||:|.|..|.|.|.||:..:|:|.|:|:||||
Mouse   205 TMLFNIHSLQWDEELCDFFGIPMTILPRIRSSSEIYGLVKSGVLEGVPISGCLGDQSAALVGQLC 269

  Fly   270 VKAGQNVCTLDDSCFVLLNTGREKLDSANGLITGIAHKLGEKAATNYTLEGAISNAGSTVTWLRD 334
            ::.||...|....||:|.|||::.::|.:||:|.:|::||.:....|.|||:::.||:.|:|:::
Mouse   270 LQDGQAKSTYGTGCFLLCNTGQKCVNSEHGLLTTVAYQLGRQEPVYYALEGSVAIAGAVVSWIKN 334

  Fly   335 KLQINTEINSNDNVVESLNTFIGENSMISSSCSSSMLNAECGLAAKRSEITFVPAFHGMYAPYWR 399
            .|||....:..:.:.|...|..|                 |         .|||||.|:|||||.
Mouse   335 NLQIIQSSSEIEKLAEVAGTSYG-----------------C---------YFVPAFSGLYAPYWD 373

  Fly   400 HDARGIILGLTSQTTAENITQAAYEATGFQIFEVLQAFKRDTPNWDRSSMQPVLTFGGDYAENLH 464
            ..|||||.|||..|...:|..||.||..||..|:|     |..|.|.......|...|....|..
Mouse   374 PSARGIICGLTQFTNKFHIAFAALEAVCFQTREIL-----DAMNSDCGIPLTHLQVDGGMTANRV 433

  Fly   465 LVQFIADIIGYMLERPQTTSPAGLGVMITAGVT--MKVVSLE----HAVKMYTPPTDVFSPTTTK 523
            |:|..|||:...:.:|.......|||.:.||..  :.|.||:    .:|:|     :.|.|....
Mouse   434 LMQLQADILCIPVMKPFMPETTALGVAMAAGAAEGVSVWSLDPKDLSSVQM-----EKFEPQINV 493

  Fly   524 NRRELLYKRWAYAVKKCLHWNNYETYEA-DIELFAQRELDPNLPVRRSVPGSIFLTTSFAMIILA 587
            ...|..|..|..||.|.:.|...::.:. |..:|:...|            ..::.:|..::|.|
Mouse   494 EESEGRYATWKKAVLKSMGWVLTQSPDGRDPSIFSSLTL------------GFYVVSSMVILIGA 546

  Fly   588 NYL 590
            .|:
Mouse   547 RYM 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8298	NP_610718.1	FGGY_GK	12..534	CDD:198347	198/527 (38%)
CG8298	NP_610718.1	glycerol_kin	21..543	CDD:273549	200/527 (38%)
Gykl1	NP_034423.2	glycerol_kin	11..513	CDD:273549	202/537 (38%)
Gykl1	NP_034423.2	FGGY_GK1-3_metazoa	11..513	CDD:212664	202/537 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833654
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	1	1.000	-	-		FOG0001035
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10196
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.810