DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8298 and KATNA1

DIOPT Version :9

Sequence 1:	NP_610718.1	Gene:	CG8298 / 36282	FlyBaseID:	FBgn0033673	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_008975.1	Gene:	KATNA1 / 11104	HGNCID:	6216	Length:	491	Species:	Homo sapiens

Alignment Length:	267	Identity:	45/267 - (16%)
Similarity:	89/267 - (33%)	Gaps:	99/267 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 TWLRDKLQ-----INTEINSNDNVVESLNTFIGENSMISSSCSSSMLNAECGLAAKRSEITFVPA 389
            |:|:.|.|     ||.|.....:::::|.:|..:::.:.:        |:..|.|...|:..:|.
Human    46 TYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKA--------AQHDLPASEGEVWSMPV 102

  Fly   390 -------------FHGMYAPYWRHDARGIILGLTSQTTAENI----------------------- 418
                         ....|:....|..|........:::|:|:
Human   103 PVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEK 167

  Fly   419 --TQAA--------YEATGFQIFEVLQAFKRD----TPN--WDRSSMQPVLTFGGDYAENLHLVQ 467
              :.||        :::||:. .::::|.:||    .||  ||            |.|:.:...:
Human   168 NKSPAAVTEPETNKFDSTGYD-KDLVEALERDIISQNPNVRWD------------DIADLVEAKK 219

  Fly   468 FIADIIGYMLERPQ-------------TTSPAGLGVMITAGVTMKVVSLEHAVKMYTPPTDVFSP 519
            .:.:.:...:..|:             ...|.|.|..:.|    |.|:.|.....:    :|.|.
Human   220 LLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLA----KAVATECKTTFF----NVSSS 276

  Fly   520 TTTKNRR 526
            |.|...|
Human   277 TLTSKYR 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8298	NP_610718.1	FGGY_GK	12..534	CDD:198347	45/267 (17%)
CG8298	NP_610718.1	glycerol_kin	21..543	CDD:273549	45/267 (17%)
KATNA1	NP_008975.1	Interaction with microtubules	1..185		21/146 (14%)
		Interaction with dynein and NDEL1. /evidence=ECO:0000250	1..75		8/28 (29%)
		Interaction with KATNB1. /evidence=ECO:0000269\|PubMed:10751153	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..185		11/97 (11%)
		AAA	241..382	CDD:214640	12/51 (24%)
		AAA	245..381	CDD:278434	12/47 (26%)
		Vps4_C	<456..489	CDD:286426
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900