DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rho-7 and RHBDF2

DIOPT Version :9

Sequence 1:	NP_001286324.1	Gene:	rho-7 / 36281	FlyBaseID:	FBgn0033672	Length:	351	Species:	Drosophila melanogaster
Sequence 2:	NP_078875.4	Gene:	RHBDF2 / 79651	HGNCID:	20788	Length:	856	Species:	Homo sapiens

Alignment Length:	215	Identity:	34/215 - (15%)
Similarity:	64/215 - (29%)	Gaps:	74/215 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 LCNLVAFAMWRVPALKSTMITYFTSNPAAKVVCWPMFLSTFSHYSAMHLFANMYVMHSFANAAAV 217
            :|.|:.|.                 ||......:.::||.|.|...:|...::....:.......
Human   639 VCGLLPFL-----------------NPEVPDQFYRLWLSLFLHAGVVHCLVSVVFQMTILRDLEK 686

  Fly   218 SLGKEQFLAVYLSAGVFSSLMSVL---YKAATSQAGMSLGASGAI-------------------- 259
            ..|..:...:::.:|:..:|.|.:   |:|....||...|....:
Human   687 LAGWHRIAIIFILSGITGNLASAIFLPYRAEVGPAGSQFGLLACLFVELFQSWPLLERPWKAFLN 751

  Fly   260 ---MTLLAYVCTQYP-------------DTQLSILFLPALTFSAG----------AGIKVLMGID 298
               :.|..::|...|             ...|:..|||.:||...          ..:....|:
Human   752 LSAIVLFLFICGLLPWIDNIAHIFGFLSGLLLAFAFLPYITFGTSDKYRKRALILVSLLAFAGL- 815

  Fly   299 FAGVVM-------GWKFFDH 311
            ||.:|:       .|.:.:|
Human   816 FAALVLWLYIYPINWPWIEH 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rho-7	NP_001286324.1	Rhomboid	186..327	CDD:396315	29/182 (16%)
RHBDF2	NP_078875.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..115
		Rhomboid_SP	128..334	CDD:289371
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..184
		Involved in interaction with FRMD8. /evidence=ECO:0000269\|PubMed:29897333	191..271
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..553
		Rhomboid	648..789	CDD:279958	20/140 (14%)
		GtrA	748..832	CDD:303012	14/84 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0705
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900