DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rho-7 and Parl

DIOPT Version :9

Sequence 1:	NP_001286324.1	Gene:	rho-7 / 36281	FlyBaseID:	FBgn0033672	Length:	351	Species:	Drosophila melanogaster
Sequence 2:	NP_001030326.1	Gene:	Parl / 287979	RGDID:	1306191	Length:	377	Species:	Rattus norvegicus

Alignment Length:	384	Identity:	153/384 - (39%)
Similarity:	216/384 - (56%)	Gaps:	59/384 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SWLPQVARRCHANVNVPILRINSGHPAARSCRQIHSN------------RKQSSNLKP---TTGE 59
            ||: |...|| .....|:|.......:|...||:...            ||....::|   .||.
  Rat     5 SWV-QRGWRC-GQTWAPLLGGGYRELSATQARQLLGRRFNLLLQQKCGFRKAPRKVEPRRSDTGS 67

  Fly    60 PAAAEQN--------------TPVPVNNVIKAVAFTGAFTVGC-FAGATILEYENTRSLI----- 104
            ...|.:.              :|.||..::|...||..|| || |..|.|.:||:.:|.:
  Rat    68 SGEAYKRSALIPPLEETVFYPSPYPVRTLLKPFFFTVGFT-GCAFGSAAIWQYESLKSRVQSYFD 131

  Fly   105 ------LEKARQARFGWWQSRSLADRDYWTQIKQDIRRHWDSLTPGDKMFAPILLCNLVAFAMWR 163
                  |:..|..:.|              .::::|.:.|:||:.|.:....|:..|.:.|.:||
  Rat   132 GIKADWLDSIRPQKEG--------------NLRKEINKWWNSLSDGQRTVTGIIAANALVFCLWR 182

  Fly   164 VPALKSTMITYFTSNPAAKVVCWPMFLSTFSHYSAMHLFANMYVMHSFANAAAVSLGKEQFLAVY 228
            ||:|..|||.|||||||:||:|.||.||||||:|..|:.|||||:.||:.:....||:|||:|||
  Rat   183 VPSLHRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSTSIVNILGQEQFVAVY 247

  Fly   229 LSAGVFSSLMSVLYKAATSQAGMSLGASGAIMTLLAYVCTQYPDTQLSILFLPALTFSAGAGIKV 293
            |||||.|:.:|.:.|.||.:.|.||||||||||:||.|||:.|:.:|:|:|||..||:||..:|.
  Rat   248 LSAGVISNFVSYVCKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPVFTFTAGNALKA 312

  Fly   294 LMGIDFAGVVMGWKFFDHAAHLGGAMFGIFWATYGAQ-IWAKRIGLLNYYHDLRRTKQK 351
            ::.:|.||:::||||||||||||||:|||::.|||.: ||..|..|:..:|::|....|
  Rat   313 IIAMDTAGMILGWKFFDHAAHLGGALFGIWYITYGHELIWKNREPLVKIWHEIRTNGPK 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rho-7	NP_001286324.1	Rhomboid	186..327	CDD:396315	82/140 (59%)
Parl	NP_001030326.1	Rhomboid	207..348	CDD:396315	83/140 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338580
Domainoid	1	1.000	179	1.000	Domainoid score	I3454
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10239
Inparanoid	1	1.050	268	1.000	Inparanoid score	I2953
OMA	1	1.010	-	-		QHG45264
OrthoDB	1	1.010	-	-		D1554324at2759
OrthoFinder	1	1.000	-	-		FOG0005057
OrthoInspector	1	1.000	-	-		oto97119
orthoMCL	1	0.900	-	-		OOG6_101864
Panther	1	1.100	-	-	LDO	PTHR43731
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3580
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910