DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RnrS and RNR2

DIOPT Version :9

Sequence 1:	NP_525111.1	Gene:	RnrS / 36280	FlyBaseID:	FBgn0011704	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_012508.1	Gene:	RNR2 / 853427	SGDID:	S000003563	Length:	399	Species:	Saccharomyces cerevisiae

Alignment Length:	401	Identity:	226/401 - (56%)
Similarity:	280/401 - (69%)	Gaps:	33/401 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SKENIADNMEKF----SLKSP--SKKILTDSTNNVRKMSIGHEANGQLAKESSTVNGIGKSANSL 61
            ||.|:...:|..    .:||.  .:|:..|:.|:...:. .|:.:....||
Yeast    22 SKSNLNKELETLREENRVKSDMLKEKLSKDAENHKAYLK-SHQVHRHKLKE-------------- 71

  Fly    62 MEKSVTPFDPSLEPLLRENPRRFVIFPIQYHDIWQMYKKAEASFWTVEEVDLSKDLTDW-HRLKD 125
            |||.        ||||.|:..|.|:|||:||:|||.||:|||||||.||:|||||:.|| :|:.:
Yeast    72 MEKE--------EPLLNEDKERTVLFPIKYHEIWQAYKRAEASFWTAEEIDLSKDIHDWNNRMNE 128

  Fly   126 DERHFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENVHSEMYSVLIDTYIRD 190
            :||.|||.||||||||||||||||||.||.||||.||:.||||||.:||:|||.||:||||||:|
Yeast   129 NERFFISRVLAFFAASDGIVNENLVENFSTEVQIPEAKSFYGFQIMIENIHSETYSLLIDTYIKD 193

  Fly   191 PHQREYLFNAIETMPAVKRKADWALSWISSKSANFGERIIAFAAVEGIFFSGSFASIFWLKKRGL 255
            |.:.|:|||||.|:|.:..||:|||.||....|.||||::|||::||:||||||||||||||||:
Yeast   194 PKESEFLFNAIHTIPEIGEKAEWALRWIQDADALFGERLVAFASIEGVFFSGSFASIFWLKKRGM 258

  Fly   256 MPGLTFSNELISRDEGLHCDFAVLMFQHLVQRPKRERIIEIIRDAVAIEQEFLTDALPVNLIGMN 320
            |||||||||||.||||||.|||.|:|.||..:|....:.:|:.:||.|||.:..|||||.|:|||
Yeast   259 MPGLTFSNELICRDEGLHTDFACLLFAHLKNKPDPAIVEKIVTEAVEIEQRYFLDALPVALLGMN 323

  Fly   321 CDLMSQYIEFVADRLLVELGVGKIYNTKNPFNFMEMISLDGKTNFFEKKVGEYQRMGVVSNPLD- 384
            .|||:||:|||||||||..|..|.|..:|||:|||.|||.||||||||:|.:||:.||:|....
Yeast   324 ADLMNQYVEFVADRLLVAFGNKKYYKVENPFDFMENISLAGKTNFFEKRVSDYQKAGVMSKSTKQ 388

  Fly   385 --NVFTLDADF 393
              ..||.:.||
Yeast   389 EAGAFTFNEDF 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RnrS	NP_525111.1	Ferritin_like	74..393	CDD:294190	209/322 (65%)
RNR2	NP_012508.1	Ferritin_like	76..399	CDD:412271	209/322 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344740
Domainoid	1	1.000	379	1.000	Domainoid score	I107
eggNOG	1	0.900	-	-		E1_COG1678
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20277
Inparanoid	1	1.050	433	1.000	Inparanoid score	I270
Isobase	1	0.950	-	0	Normalized mean entropy	S211
OMA	1	1.010	-	-		QHG61695
OrthoFinder	1	1.000	-	-		FOG0001155
OrthoInspector	1	1.000	-	-		oto100237
orthoMCL	1	0.900	-	-		OOG6_100537
Panther	1	1.100	-	-	LDO	PTHR23409
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1105
SonicParanoid	1	1.000	-	-		X1121
TreeFam	1	0.960	-	-
	16	15.740