DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RnrS and RRM2

DIOPT Version :9

Sequence 1:	NP_525111.1	Gene:	RnrS / 36280	FlyBaseID:	FBgn0011704	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_001159403.1	Gene:	RRM2 / 6241	HGNCID:	10452	Length:	449	Species:	Homo sapiens

Alignment Length:	377	Identity:	274/377 - (72%)
Similarity:	307/377 - (81%)	Gaps:	8/377 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SPSKKI-LTDSTNNVRKMSIGHEANGQLAKESSTVNGIGKSANSLMEKSVTPFDPSLEPLLRENP 81
            ||.|.: |.|..|....:|      |.....|.|...|.:.......|:..| ....||||||||
Human    80 SPLKGLSLVDKENTPPALS------GTRVLASKTARRIFQEPTEPKTKAAAP-GVEDEPLLRENP 137

  Fly    82 RRFVIFPIQYHDIWQMYKKAEASFWTVEEVDLSKDLTDWHRLKDDERHFISHVLAFFAASDGIVN 146
            ||||||||:|||||||||||||||||.||||||||:..|..||.:||:|||||||||||||||||
Human   138 RRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVN 202

  Fly   147 ENLVERFSQEVQITEARCFYGFQIAMENVHSEMYSVLIDTYIRDPHQREYLFNAIETMPAVKRKA 211
            ||||||||||||||||||||||||||||:||||||:||||||:||.:||:|||||||||.||:||
Human   203 ENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKA 267

  Fly   212 DWALSWISSKSANFGERIIAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDF 276
            ||||.||..|.|.:|||::||||||||||||||||||||||||||||||||||||||||||||||
Human   268 DWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDF 332

  Fly   277 AVLMFQHLVQRPKRERIIEIIRDAVAIEQEFLTDALPVNLIGMNCDLMSQYIEFVADRLLVELGV 341
            |.|||:|||.:|..||:.|||.:||.|||||||:||||.||||||.||.||||||||||::|||.
Human   333 ACLMFKHLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGF 397

  Fly   342 GKIYNTKNPFNFMEMISLDGKTNFFEKKVGEYQRMGVVSNPLDNVFTLDADF 393
            .|::..:|||:|||.|||:||||||||:|||||||||:|:|.:|.|||||||
Human   398 SKVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSSPTENSFTLDADF 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RnrS	NP_525111.1	Ferritin_like	74..393	CDD:294190	259/318 (81%)
RRM2	NP_001159403.1	PLN02492	130..449	CDD:215272	259/318 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152060
Domainoid	1	1.000	458	1.000	Domainoid score	I492
eggNOG	1	0.900	-	-		E1_COG1678
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20277
Inparanoid	1	1.050	547	1.000	Inparanoid score	I1157
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61695
OrthoDB	1	1.010	-	-		D316743at33208
OrthoFinder	1	1.000	-	-		FOG0001155
OrthoInspector	1	1.000	-	-		otm42128
orthoMCL	1	0.900	-	-		OOG6_100537
Panther	1	1.100	-	-	O	PTHR23409
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1105
SonicParanoid	1	1.000	-	-		X1121
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800