DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RnrS and suc22

DIOPT Version :9

Sequence 1:	NP_525111.1	Gene:	RnrS / 36280	FlyBaseID:	FBgn0011704	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_596546.1	Gene:	suc22 / 2540381	PomBaseID:	SPBC25D12.04	Length:	391	Species:	Schizosaccharomyces pombe

Alignment Length:	399	Identity:	240/399 - (60%)
Similarity:	289/399 - (72%)	Gaps:	25/399 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DNMEKFSL-KSPSKKILTDSTNNVRKM---SIGHEANGQLAKESSTVNG----IGKSANSLMEKS 65
            :::|:||. |...:::..||...|||:   ||....|.....|.....|    :||..:.|.
pombe     4 EHLEEFSYPKEHGEEVEYDSEQGVRKIYVKSIKETFNFDNVSEEEKQEGGDYYLGKKEDELD--- 65

  Fly    66 VTPFDPSLEPLLRENPRRFVIFPIQYHDIWQMYKKAEASFWTVEEVDLSKDLTDW-HRLKDDERH 129
                    |.:||.||.|||:|||:||:|||.||||||||||.||:||||||.|| ::|..|||:
pombe    66 --------EVVLRPNPHRFVLFPIKYHEIWQFYKKAEASFWTAEEIDLSKDLVDWDNKLNADERY 122

  Fly   130 FISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENVHSEMYSVLIDTYIRDPHQR 194
            |||.|||:||||||||||||:||||.||||.||||.|||||.:||:|||.||:|:|||||:|.::
pombe   123 FISTVLAYFAASDGIVNENLLERFSSEVQIPEARCVYGFQIMIENIHSETYSLLLDTYIREPKEK 187

  Fly   195 EYLFNAIETMPAVKRKADWALSWISSKSANFGERIIAFAAVEGIFFSGSFASIFWLKKRGLMPGL 259
            :..|:||.||.::|.||.|||.||:.:.:.:..|::|||||||||||||||||||||||||||||
pombe   188 QRHFDAILTMGSIKAKAKWALRWINDEDSTYAIRLVAFAAVEGIFFSGSFASIFWLKKRGLMPGL 252

  Fly   260 TFSNELISRDEGLHCDFAVLMFQHLVQRPKRERIIEIIRDAVAIEQEFLTDALPVNLIGMNCDLM 324
            |||||||.||||||.|||.|||.||..||.|:.:..||.:||.||:|:.||||||:|:|||.|||
pombe   253 TFSNELICRDEGLHTDFACLMFSHLKHRPGRKVVEAIIVEAVDIEKEYFTDALPVSLLGMNKDLM 317

  Fly   325 SQYIEFVADRLLVELGVGKIYNTKNPFNFMEMISLDGKTNFFEKKVGEYQRMGVVSNPL-----D 384
            .||||||||||||.||..|.||..|||:|||.|||.||||||||||.:||..||:|...     |
pombe   318 CQYIEFVADRLLVALGNDKYYNVTNPFDFMENISLAGKTNFFEKKVSDYQIAGVMSGTKRAEKDD 382

  Fly   385 NVFTLDADF 393
            :.||:|.||
pombe   383 HTFTIDEDF 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RnrS	NP_525111.1	Ferritin_like	74..393	CDD:294190	221/324 (68%)
suc22	NP_596546.1	Ferritin_like	66..391	CDD:294190	221/324 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	386	1.000	Domainoid score	I123
eggNOG	1	0.900	-	-		E1_COG1678
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20277
Inparanoid	1	1.050	448	1.000	Inparanoid score	I298
OMA	1	1.010	-	-		QHG61695
OrthoFinder	1	1.000	-	-		FOG0001155
OrthoInspector	1	1.000	-	-		oto101991
orthoMCL	1	0.900	-	-		OOG6_100537
Panther	1	1.100	-	-	LDO	PTHR23409
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1105
SonicParanoid	1	1.000	-	-		X1121
TreeFam	1	0.960	-	-
	14	13.860