DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GalT1 and B3GNT8

DIOPT Version :9

Sequence 1:	NP_788328.1	Gene:	GalT1 / 36279	FlyBaseID:	FBgn0053145	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_001372577.1	Gene:	B3GNT8 / 374907	HGNCID:	24139	Length:	397	Species:	Homo sapiens

Alignment Length:	449	Identity:	104/449 - (23%)
Similarity:	167/449 - (37%)	Gaps:	129/449 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WNPEKIEEQSSLLAAEYSSSSGAAASGSEDETVTTSGALRSKAKLRKRQLRNRMPLPRMLRRLGC 69
            ||    ::|..|         |:..||...||    |..::.......::.:....|:.|||
Human    73 WN----QQQWRL---------GSLPSGDSTET----GGCQAWGAAAATEIPDFASYPKDLRR--- 117

  Fly    70 YTLSAFLICGLLLVYLPLVYLDVHKRSAGLPDWTSETSRSIADYLDIGLSSGVIVPKDFCRNKTF 134
            :.|||  .|                ||  .|.|......|     .:...|...||        :
Human   118 FLLSA--AC----------------RS--FPQWLPGGGGS-----QVSSCSDTDVP--------Y 149

  Fly   135 LVIAVCTGVDNFIQRHTIRETWGNTTEFNYPAFGKLHGHLKGHYLPPLPDRLKMYGDYLSGEGQS 199
            |::||.:....|.:|..:|||||:                      |.|
Human   150 LLLAVKSEPGRFAERQAVRETWGS----------------------PAP---------------- 176

  Fly   200 LTASVRIVFIVGRQKDEAMLGNETLNRIHIESEKYNDIIQENFVDSYNNLTLKSVMALKHISRSC 264
               .:|::|::|....||  |.:..:.:..||.:|:|::..:|:|...|.|||.::.|..:.|.|
Human   177 ---GIRLLFLLGSPVGEA--GPDLDSLVAWESRRYSDLLLWDFLDVPFNQTLKDLLLLAWLGRHC 236

  Fly   265 FNTAVYFLKCDDDTFVNIPNLLNFLLGGTIPLYNDTLDYHDRSTYLVTAPQTRLKASSDVLY-GH 328
             .|..:.|:..||.||:.|.||                     .:|...|    .||:..|| |.
Human   237 -PTVSFVLRAQDDAFVHTPALL---------------------AHLRALP----PASARSLYLGE 275

  Fly   329 QFCNVVPVSEVSSKWYMPSYMYKPESYPKYLSGAGYLMSIDVVQRLFEASLNTTLVYLEDVYITG 393
            .|...:|:.:....:|:|...:: ..||.|.||.||:::..:...|..|:........|||| ||
Human   276 VFTQAMPLRKPGGPFYVPESFFE-GGYPAYASGGGYVIAGRLAPWLLRAAARVAPFPFEDVY-TG 338

  Fly   394 LCAQKAKINRHHHPLFSFA----HSKQMCAFKGTITQHQLKDDSMVSAWNYVSNYSIKC 448
            ||.:...:....||.|..|    .:...|||:..:....|...:.:..|..:.:..::|
Human   339 LCIRALGLVPQAHPGFLTAWPADRTADHCAFRNLLLVRPLGPQASIRLWKQLQDPRLQC 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GalT1	NP_788328.1	Galactosyl_T	204..407	CDD:304462	56/203 (28%)
B3GNT8	NP_001372577.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..58
B3GNT8	NP_001372577.1	Galactosyl_T	162..349	CDD:419759	64/257 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D174158at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X41
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820