DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ADD1 and ATRX

DIOPT Version :10

Sequence 1:NP_725094.1 Gene:ADD1 / 36278 FlyBaseID:FBgn0026573 Length:1199 Species:Drosophila melanogaster
Sequence 2:NP_000480.3 Gene:ATRX / 546 HGNCID:886 Length:2492 Species:Homo sapiens


Alignment Length:1408 Identity:283/1408 - (20%)
Similarity:499/1408 - (35%) Gaps:405/1408 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 SAPGSESGLAKVATP------SPSPLAKLDA-DFTSSKFEMHPSLSDEERRFYLKMYPNVDLVNQ 61
            |...||:.:...:.|      .|.|:...|. ||...:|.....:..|               |.
Human   108 SNENSENDITMQSLPKGTVIVQPEPVLNEDKDDFKGPEFRSRSKMKTE---------------NL 157

  Fly    62 RK---------VHCTVCKLHLGTAPAAESNIKMHPILRVTHCVKCHDFYNSGEFSKGEDGSELYC 117
            :|         |.||.|...:.  ...:.:|..||.|:|..|..|..:|.|.:.|:..||.:..|
Human   158 KKRGEDGLHGIVSCTACGQQVN--HFQKDSIYRHPSLQVLICKNCFKYYMSDDISRDSDGMDEQC 220

  Fly   118 RWCGQGGEVYCCSTCPYVFCKSCIVKNLSKGVIVDI-EQNENWNCFSCTSKILWPL----RAQHW 177
            |||.:||.:.||..|...|||.||::||.:..:..| ::|..|.|:.|..:.|..|    .:...
Human   221 RWCAEGGNLICCDFCHNAFCKKCILRNLGRKELSTIMDENNQWYCYICHPEPLLDLVTACNSVFE 285

  Fly   178 ALVNYLQTQKRAL-----QTLQLPEVEARRQMLKDNSNC----------C--------------- 212
            .|...||..|:.:     ::.::.|..:|....|.:|||          |               
Human   286 NLEQLLQQNKKKIKVDSEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSVTYSYSALIVPK 350

  Fly   213 -RLAKSK-----TSSLSDSMESLESNVSKRSQGSSAGSSKRGSMPKTIPPGPPSKRA-------- 263
             .:.|:|     |::::.|........:..|:.|||...::....|::.  ...|:|        
Human   351 EMIKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSVL--ADIKKAHLALEEDL 413

  Fly   264 ----------------------------KASNNEVVCTPDLLSMLEPDCQLS------------- 287
                                        ||...|..|..:...:.:.:.:||             
Human   414 NSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNV 478

  Fly   288 -----VTPKPTGRQTVTAANITTPRIVTVQQNYQPGQSSSNSGSNGSVSGSSSVP-------PTR 340
                 .|.|.||.:...:.....|:       |:|..:|.:...: .||..||||       .|.
Human   479 PTEEQRTNKSTGGEHKKSDRKEEPQ-------YEPANTSEDLDMD-IVSVPSSVPEDIFENLETA 535

  Fly   341 SSLPPPLVLSGSGIRYRQNAPGGVSGVVRRTVVPNSVKTTGPVFHTINGFKVDLNSAAQQDSYRL 405
            ..:...:...|.|           |....:.|..:|||               ||.:::.:...:
Human   536 MEVQSSVDHQGDG-----------SSGTEQEVESSSVK---------------LNISSKDNRGGI 574

  Fly   406 PNGRLIQVKRQVPQTIQPASTVPTP-PTPPALVVPQVGPGVV---IRPRAP-------------I 453
            .:....:|.:::...:.|.|...:| .......|||...|..   :.|:..             :
Human   575 KSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHL 639

  Fly   454 TTNRPSLHISTYGSNMGIYNPQTNQQQRAPQVRVGNANPAPPPLQGLPPNANGGQTLMITPAPQP 518
            ..|..||.:            :.:..:|:|:|:   ..|...|.:..|..:|..:....|...:.
Human   640 VENEVSLLL------------EESDLRRSPRVK---TTPLRRPTETNPVTSNSDEECNETVKEKQ 689

  Fly   519 APKVP-----------TLVRLTFPNTPMGQARAQLQEQIFSAMDICTHLTGKVVSLTHSNAYNQV 572
            ...||           :.:....||......:::..:| .|..|....:..:|..::||::    
Human   690 KLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQ-NSDSDEMLAILKEVSRMSHSSS---- 749

  Fly   573 RSYLELKELYIHMSYLMTYAIGRFKNLQEKCLVDMREKGFKNDANSLENGQLAADKQASDDEDNE 637
             |..::.|  ||.::              |.|.|::.:..|:|...        .|:.|....::
Human   750 -SDTDINE--IHTNH--------------KTLYDLKTQAGKDDKGK--------RKRKSSTSGSD 789

  Fly   638 IEIVEPKTDTITIDSDNEDDMPSTSTATQQEQPQETAIM-KITSV---------TSEASKKELQE 692
            .:..:.|:...:|.|..:....|.|:....|..:|...| ||.:.         |.:....|.::
Human   790 FDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEK 854

  Fly   693 NNQADIDVAAFSSTILASLLEVEVNEGASEPKPVSPG-----QKKQPRKK------TTNKPNPAL 746
            :::..:|                 |:|....|....|     ::||.|:.      |.:| :..:
Human   855 HSKKGMD-----------------NQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDK-DTTI 901

  Fly   747 LQLERQRMEDMKKSDAKLKMKVMVKLKRAEDEF---EVARKWVEDMKQGQELATKIKDSKAATPS 808
            ::| |.|:.  ||..|......:.||...|:.|   || ||..|..::.:.|.||          
Human   902 MEL-RDRLP--KKQQASASTDGVDKLSGKEESFTSLEV-RKVAETKEKSKHLKTK---------- 952

  Fly   809 NKTQKPSENLK-ISEKGSSAKKESTKQHGEGD----KENTKNKEKIGDILKAAIKAKIGENEKLM 868
             ..:|..:.|. |:||  ..||:.:.:..|.|    |:.|:.|:|..|..|..||.   |.:...
Human   953 -TCKKVQDGLSDIAEK--FLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKM---EQQYES 1011

  Fly   869 AED--VQLPVDELLTEKDKELDKETLTSTEPETNKKSGTEKGSDKKQHLT---KENNVKGESKDE 928
            :.|  .:||..|.:....|.:.:....:|:.|...|...:|.|.||..|:   :::..||:|.|.
Human  1012 SSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDS 1076

  Fly   929 SKTDQKSD----------CK-KGPDS----ECTEIEEETEMLSEKGYGGSEKEQGDTENMEDETS 978
            |: |:||.          || .|..|    :|:..:.|...:.|.|...|:|.            
Human  1077 SE-DKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKR------------ 1128

  Fly   979 SERPTLIGEIEKNLLKEGKEESSEKFDKEVE---PSKDVGKDSPTTQGKGQDSDKLKNA---RAG 1037
                  :..||   |:|.:..||::..||::   .|.|..:.|...:.|.|.:...|.|   :..
Human  1129 ------LKRIE---LRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEK 1184

  Fly  1038 LKNSTQDASNTVEPPVAASN-----ENDQSSVGELIERMDVTELDEKPKELL------------D 1085
            .:||.:.::...:..:.:|:     ::||:|:||  ...|..::....:.|:            |
Human  1185 KRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGE--GSSDEQKIKPVTENLVLSSHTGFCQSSGD 1247

  Fly  1086 CALDEVIPMEGIELSDDTEDLIKALGSPSVLPSQNTKDN-ETDLDANDFIGNLPLETTEPPEILL 1149
            .||.:.:|:. ::..||..|....:....:|  :..|.| .:|.|.:        ...||.|   
Human  1248 EALSKSVPVT-VDDDDDDNDPENRIAKKMLL--EEIKANLSSDEDGS--------SDDEPEE--- 1298

  Fly  1150 KEDECKVEKTTGISQVGAPSPAENGDTEMESTLEA-SDSAPDE 1191
                       |..:.|..:....||.|.::.:.: |||..:|
Human  1299 -----------GKKRTGKQNEENPGDEEAKNQVNSESDSDSEE 1330

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADD1NP_725094.1 ADDz_ATRX 62..164 CDD:277252 37/111 (33%)
PTZ00121 <720..1057 CDD:173412 91/381 (24%)
ATRXNP_000480.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..147 9/38 (24%)
ADDz_ATRX 167..270 CDD:277252 37/104 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 445..516 12/77 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 535..576 9/66 (14%)
PxVxL motif 581..594 2/12 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 593..616 6/22 (27%)
PTZ00108 <642..857 CDD:240271 44/259 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 649..956 69/372 (19%)
PTZ00121 <791..1438 CDD:173412 138/627 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 968..1479 93/415 (22%)
Interaction with DAXX 1189..1326 29/163 (18%)
HepA <1543..2191 CDD:440319
DEXHc_ATRX 1560..1803 CDD:350826
DEGH box 1719..1722
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1913..2000
Interaction with MECP2. /evidence=ECO:0000269|PubMed:17296936 2010..2280
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2462..2492
Blue background indicates that the domain is not in the aligned region.

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