DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ADD1 and Dnmt3b

DIOPT Version :9

Sequence 1:	NP_725094.1	Gene:	ADD1 / 36278	FlyBaseID:	FBgn0026573	Length:	1199	Species:	Drosophila melanogaster
Sequence 2:	NP_001003959.1	Gene:	Dnmt3b / 444985	RGDID:	1303274	Length:	859	Species:	Rattus norvegicus

Alignment Length:	173	Identity:	41/173 - (23%)
Similarity:	66/173 - (38%)	Gaps:	38/173 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DFTSSKFEMHPSL------------SDEERRFYLKMYPNVDLVNQR---KVHCTVCKLHLGTAPA 78
            ||.:|::...|..            .|||.|..:..    |:.|.:   :..|..|        .
  Rat   392 DFAASEYSTPPKRLKTNSYGGKDRGEDEESRERMAS----DVTNNKGNLEDRCLSC--------G 444

  Fly    79 AESNIKMHPILRVTHCVKCHDFYNSGEFSKGEDGSELYCRWCGQGGEVYCCS--TCPYVFCKSCI 141
            .::.:..||:.....|..|.|.:....:...|||.:.||..|.:|.|:..||  :|...||..|:
  Rat   445 KKNPVSFHPLFEGGLCQSCRDRFLELFYMYDEDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECL 509

  Fly   142 VKNLSKGVIVDIEQNENWNCFSCTSK----IL-----WPLRAQ 175
            ...:..|...|.:..|.|:|:.|..:    :|     |.:|.|
  Rat   510 EVLVGTGTAEDAKLQEPWSCYMCLPQRCHGVLRRRKDWNMRLQ 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADD1	NP_725094.1	ADDz_ATRX	62..164	CDD:277252	26/106 (25%)
Dnmt3b	NP_001003959.1	Dnmt3b_related	229..315	CDD:99896
		ADDz_Dnmt3b	436..555	CDD:277254	31/125 (25%)
		Dcm	580..>762	CDD:223348
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto97953
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.960