DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADD1 and atrx

DIOPT Version :9

Sequence 1:	NP_725094.1	Gene:	ADD1 / 36278	FlyBaseID:	FBgn0026573	Length:	1199	Species:	Drosophila melanogaster
Sequence 2:	XP_021336651.1	Gene:	atrx / 323299	ZFINID:	ZDB-GENE-030912-11	Length:	2053	Species:	Danio rerio

Alignment Length:	1282	Identity:	255/1282 - (19%)
Similarity:	448/1282 - (34%)	Gaps:	360/1282 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PSPLAKLDAD-FTSSKFEMHPSLSDEERRFYLKMYPNVDLVNQRKVHCTVCKLHLGTAPAAESNI 83
            |.|:|....| |...:|......:.||.   .:..|:..|  |...:||.|...:.  ...:.:|
Zfish   120 PEPVANETKDEFRGPEFRNKGGKAKEEG---ARKRPDDQL--QEIFNCTACGQQVN--HFQKDSI 177

  Fly    84 KMHPILRVTHCVKCHDFYNSGEFSKGEDGSELYCRWCGQGGEVYCCSTCPYVFCKSCIVKNLSKG 148
            ..||.|.|..|..|..:|.|.:.||.::|.:..||||.:||.:.||..|...|||.||::||.:.
Zfish   178 FQHPALHVLICKSCFKYYMSDDISKDDEGMDEQCRWCAEGGNLMCCDYCSNAFCKKCILRNLGRK 242

  Fly   149 VIVDI-EQNENWNCFSCTSKILWPLRAQHWALVNYLQTQKRALQTLQLPEVEARRQMLKDNSNCC 212
            .:.:| .:...|:|:.|                              .||      .|:|:...|
Zfish   243 ELSEIMSEQSKWHCYIC------------------------------CPE------PLQDHVKTC 271

  Fly   213 RLAKSKTSSLSDSMESLESNVSKRSQGSSAGSSKRGSMPKTIPPGPPSKRAKASNNEVVCTPDLL 277
            ...          :.:|||: |::.:|....:.:.....|.:      ||.|.:.|......|..
Zfish   272 EKV----------LLNLESS-SRKPKGEHDKTKREERKHKHV------KREKTAVNGQDYASDGA 319

  Fly   278 SMLEPDCQLSVTPKPTGRQT---VTAANITTPRIVTVQQNYQPGQSSSNSGSNGSVSGSSSV--- 336
            ..|...|:....||...::|   :...|......|...|....||.:| :.|...:....||
Zfish   320 GTLTFSCKTLTVPKELVKKTKKLIETTNGLNRTFVQFLQQTSKGQEAS-AVSYRHLKAFKSVLAD 383

  Fly   337 -PPTRSSLPPPL--VLSGSGIRYR---QNAPGGVSGVVRRTVVPNSVKTTGPVFHTINGFKVDLN 395
             ....::|...|  .....|::::   :..|.....|....|..|..:.| ||...      ||:
Zfish   384 LKKAHAALEESLENEFESKGLKFQNGEEQRPSNSQSVENAVVNSNHTEPT-PVKED------DLD 441

  Fly   396 SA-----------AQQDSYRLPNGRLIQVKRQVPQTIQPASTVPTPPTPPALVVPQVGPGVVIRP 449
            .:           .||||      .|..|:.:.|                              |
Zfish   442 CSTKNHNPVGEEETQQDS------NLADVEMESP------------------------------P 470

  Fly   450 RAPITTNRPSLHISTYGSN----MGIYNPQTNQQQRAPQVRVGNANPAPPPLQGLPPNANGGQTL 510
            .:|......|...|....|    .|....:..:|:.|.....|:..||...|.         :.:
Zfish   471 HSPEKAQEQSEERSEEKENEEKENGEKENEAKEQEIADNFEEGSVPPAEESLD---------KDI 526

  Fly   511 MITPAPQPAPKVPTLVRLTFPNTPMGQARAQLQEQIFSAMDICT--------HLTGKVVSLTHSN 567
            :..|     |.||                    |::|..::...        :||....:.:::.
Zfish   527 VSIP-----PSVP--------------------EELFEMVESLAVKKENNDDNLTDSSDNKSNTE 566

  Fly   568 AYNQVRSYLEL-KELYIHMSYL-MTYAIGRFKNLQEKCLVDMREKGFKNDANSLENGQLAADKQA 630
            .....:|..:| |:|.:.::.: :...|.|.|:.::....||       |..:|::||   |.:.
Zfish   567 VVESKKSLTKLGKKLVVKLTPVPLKITIKRDKSREQSPSEDM-------DGEALKDGQ---DSRR 621

  Fly   631 SDDEDNEIEIVEPKTDTITIDSDNEDDMPSTSTATQQEQPQETAIMKIT-SVTSEASKKELQENN 694
            |                           |...|...::.|:..:..|:. |...|.|...::|
Zfish   622 S---------------------------PRMKTTPLRKSPEAKSKRKLNMSKADEKSSDAVKE-- 657

  Fly   695 QADIDVAAFSSTILASLLEVEVNEGASEPKPVSPGQKKQPR--KKTTNKPNPALLQLERQRMED- 756
            |:|.|.......:.::.|:...:|  |||:..||.:.|:.|  .::|.||.      .::::|:
Zfish   658 QSDSDSDEVPEVLQSAALKDSSDE--SEPENTSPKRTKKRRLSSRSTAKPK------TKRKLEEG 714

  Fly   757 ------------MKKSDAKLKM--------------KVMVKLKRAEDEFEVARKWVEDMKQGQEL 795
                        .||..||.|.              |.:.||.:.:...:.::...:|..:|.:
Zfish   715 SSESDDSEKPSAAKKRSAKKKKGKESDSSNHNSDLEKEIKKLSKVDSGKKKSKSTKKDEDEGSK- 778

  Fly   796 ATKIKDSKAATPSNKTQKPSENLKISEKGSSAKKESTKQHGEGDKENTKNKEKIGDILKAAIKA- 859
              ::|.....:...|.:...|..|..|:.||:.:|..::....:.....:::||..||::.|.:
Zfish   779 --EVKKGPKRSFERKRRSQREKAKTKEESSSSDEEEEEEKQADNSGEDSDQQKIKPILESVIASI 841

  Fly   860 -----KIGENEKLMAEDVQLPVDE-----------LL---------------------------T 881
                 ..|:..:|..|..|:..|:           ||                           |
Zfish   842 DGFHQSSGDEVELKNEASQVVDDDDDPENRIAKRMLLAQIKANYSSGADSSSDDENADKEDGDST 906

  Fly   882 EKDKE-LDKETLTSTEPETNKKSGTE----KGSDKKQHLTKENNV-KGESKDESKTDQKSDCKK- 939
            :|:|: ..||..:.::.||...||::    ||..:.:.|.|:.:: :|||.:|:....|.:.||
Zfish   907 KKEKDNAKKEDESDSDEETTSDSGSDVDLKKGGRRHRLLRKKLSLSEGESDEENAVKNKKETKKR 971

  Fly   940 ------GPDSECTEIEEETEMLSEKGYGGSEKEQGDTENMEDETSSERPTLIGEIEKNLLKEGKE 998
                  ..||..::.:......|:    .|...:..:|:.:||.|::|.|   ...|...|: ||
Zfish   972 GRRKVDSDDSADSDFKHSRSDSSD----ASALSEAVSEDEDDEKSTKRKT---RSSKKAAKD-KE 1028

  Fly   999 ESSEKFDK-----EVEPSKDVGKDSPTTQGKGQDSDK-LKNARAGLKNSTQDASNTVEPPVAASN 1057
            .|.:|..|     :|:.|...||.......:|.:.|| ....|..::...:|.....|...|...
Zfish  1029 RSYKKEKKKRRRIKVQESSSSGKSGEEEGEEGDEDDKGTPKGRKKIRKIIKDDKLRTETRDALKE 1093

  Fly  1058 ENDQSSVGELIERMDVTELDEKPKELLD--------CALDEVIPMEGIELSDDTEDLIKALGSPS 1114
            |.|:..  .:.||   ..|.||.:|.::        |.:...:.::  |..:..|.|::
Zfish  1094 EEDRRK--RIAER---ERLREKLRETIEVKESSQVTCPITTKLVLD--EDEETKEPLVQ------ 1145

  Fly  1115 VLPSQNTKDNETDLDANDFIGNLPLETTEPPEILLKEDECKVEKTTG 1161
            |..:..||.....:|...|:.:...|:..           ||||:.|
Zfish  1146 VHRNMVTKLKPHQVDGVQFMWDCCCESVR-----------KVEKSAG 1181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADD1	NP_725094.1	ADDz_ATRX	62..164	CDD:277252	34/102 (33%)
atrx	XP_021336651.1	ADDz_ATRX	158..261	CDD:277252	35/134 (26%)
		Neuromodulin_N	<594..1151	CDD:331332	126/627 (20%)
		SNF2_N	1157..1483	CDD:306645	8/36 (22%)
		HELICc	1602..1746	CDD:238034
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	115	1.000	Domainoid score	I5971
eggNOG	1	0.900	-	-		E2759_KOG1015
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46357
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4866
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.030