DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ADD1 and dnmt3bb.2

DIOPT Version :9

Sequence 1:	NP_725094.1	Gene:	ADD1 / 36278	FlyBaseID:	FBgn0026573	Length:	1199	Species:	Drosophila melanogaster
Sequence 2:	NP_571461.1	Gene:	dnmt3bb.2 / 30659	ZFINID:	ZDB-GENE-990712-11	Length:	1448	Species:	Danio rerio

Alignment Length:	185	Identity:	42/185 - (22%)
Similarity:	68/185 - (36%)	Gaps:	36/185 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 PSLSDEERRFYLKMYPNVD--LVNQRKVH--CTVCKLHLGTAPAAESNIKMHPILRVTHCVKCHD 99
            |::..|.|:...|.:..|.  |.|:||:.  |..|        .:.|...:||:.....|..|..
Zfish   993 PTVQIESRQNSQKRHQMVHEFLKNKRKIEDFCLSC--------GSMSVDIIHPLFEGKLCTNCKF 1049

  Fly   100 FYNSGEFSKGEDGSELYCRWCGQGGEVYCC--STCPYVFCKSCIVKNLSKGVIVDIEQNENWNCF 162
            .:....:...|||.:.||..|..|.||..|  .:|...||..|:...:.:|....::..:.|.|:
Zfish  1050 NFTETLYRYDEDGYQSYCTVCCSGMEVILCGHDSCCRSFCVDCLDILVCQGTFDQLKNVDPWTCY 1114

  Fly   163 SCTSKIL---------WPLRAQ-------------HWALVNYLQTQKRALQTLQL 195
            .|..:..         |.:|.|             |....:....|:|.::.|.|
Zfish  1115 LCAPETSSGALKPRHDWSIRVQEFFANDTGMEFEPHRVYPSIPAIQRRPIRVLSL 1169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADD1	NP_725094.1	ADDz_ATRX	62..164	CDD:277252	26/105 (25%)
dnmt3bb.2	NP_571461.1	CH	16..>81	CDD:278723
		Dnmt3b_related	790..873	CDD:99896
		PHD_SF	1020..1139	CDD:304600	28/126 (22%)
		Dcm	1163..>1325	CDD:223348	2/7 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	1	0.960