DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ADD1 and Dnmt3b

DIOPT Version :9

Sequence 1:	NP_725094.1	Gene:	ADD1 / 36278	FlyBaseID:	FBgn0026573	Length:	1199	Species:	Drosophila melanogaster
Sequence 2:	XP_006498745.1	Gene:	Dnmt3b / 13436	MGIID:	1261819	Length:	872	Species:	Mus musculus

Alignment Length:	188	Identity:	45/188 - (23%)
Similarity:	73/188 - (38%)	Gaps:	40/188 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SNSAPGSESGLAKVATPSPSPLAKLDADFTSSKFEMHPSLSDEERRFYLKMYPNVDLVNQR---K 63
            :|.:..|||       |.|..| |.::.....:.|      |||.|..:..    ::.|.:   :
Mouse   403 TNDSAASES-------PPPKRL-KTNSYGGKDRGE------DEESRERMAS----EVTNNKGNLE 449

  Fly    64 VHCTVCKLHLGTAPAAESNIKMHPILRVTHCVKCHDFYNSGEFSKGEDGSELYCRWCGQGGEVYC 128
            ..|..|        ..::.:..||:.....|..|.|.:....:...|||.:.||..|.:|.|:..
Mouse   450 DRCLSC--------GKKNPVSFHPLFEGGLCQSCRDRFLELFYMYDEDGYQSYCTVCCEGRELLL 506

  Fly   129 CS--TCPYVFCKSCIVKNLSKGVIVDIEQNENWNCFSCTSK----IL-----WPLRAQ 175
            ||  :|...||..|:...:..|...|.:..|.|:|:.|..:    :|     |.:|.|
Mouse   507 CSNTSCCRCFCVECLEVLVGAGTAEDAKLQEPWSCYMCLPQRCHGVLRRRKDWNMRLQ 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADD1	NP_725094.1	ADDz_ATRX	62..164	CDD:277252	26/106 (25%)
Dnmt3b	XP_006498745.1	Dnmt3b_related	242..328	CDD:99896
		ADDz_Dnmt3b	448..567	CDD:277254	31/125 (25%)
		Dcm	593..>755	CDD:223348
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	1	0.960