Protein Alignment ADD1 and LOC1280894

DIOPT Version :10

• Sequence 1: NP_725094.1
• Gene: ADD1 / 36278
• FlyBaseID: FBgn0026573
• Length: 1199
• Species: Drosophila melanogaster
• Sequence 2: XP_061510381.1
• Gene: LOC1280894 / 1280894
• VectorBaseID: AGAMI1_007476
• Length: 1616
• Species: Anopheles gambiae
• Alignment Length: 1565
• Identity: 410/1565 - (26%)
• Similarity: 634/1565 - (40%)
• Gaps: 468/1565 - (29%)

  Fly    22 PLAKLDADFTSSKFEMHPSLSDEERRFYLKMYPNVDLVNQRKVHCTVCKLHLGTAPAAESNIKMH 86
            |....|.|.....||  ...|.:||:::::.:|||..:.:|::|||.|..|:||||.:|:.|:||
Mosquito     2 PAEFYDEDGFRLSFE--NDTSPDERQYFMRAFPNVSKIAERRIHCTTCNAHIGTAPVSEAVIRMH 64

  Fly    87 PILRVTHCVKCHDFYNSGEFSKGEDGSELYCRWCGQGGEVYCCSTCPYVFCKSCIVKNLSKGVIV 151
            |:||||||..||.|||||:|.|||||||||||||||||||:|||.|||||||||||:|||:..:.
Mosquito    65 PVLRVTHCRNCHAFYNSGDFDKGEDGSELYCRWCGQGGEVFCCSKCPYVFCKSCIVRNLSRACVQ 129

  Fly   152 DIEQNENWNCFSCTSKILWPLRAQHWALVNYLQTQKRALQTLQLPEVEARRQMLKDNSNCC---- 212
            ||.:||||:||.|..:|:|.||||||||.|:::.||:.::...|........|.||.:.||
Mosquito   130 DIVRNENWHCFGCAPRIMWHLRAQHWALENFIEKQKKEIKNQDLSPNVISALMKKDRTTCCPGKG 194

  Fly   213 -----------------------RLAKSKT----------------------------------- 219
                                   :.|..:|
Mosquito   195 QNRKSVNATATAPMITSPVSATKKTAAKRTYGEVSGKREGSMEGGPRLEPVVSIPPLAHSILGQL 259

  Fly   220 ---------------SSLSDSMESLESNV-SKRSQGSSAGSSK--RGSMPKT------IPPGPPS 260
                           ::::.|..|:.|:| :..|.|.:|||.|  :.|.|.:      .||....
Mosquito   260 DVDPGIALPGNAQGDAAIASSSGSVGSSVTTSSSSGKAAGSKKPRKSSTPNSDSGQAARPPQAKK 324

  Fly   261 KRAKASNNEVVCTPDLLSMLEPDCQLSVTPKPT----------GRQTVTAANITTPRI--VTVQQ 313
            || .|.|||||||||::|||..|......|:.|          |:..|..|....|.:  .|...
Mosquito   325 KR-MAGNNEVVCTPDIMSMLSDDGPTVGQPQTTPSRPPIVTVGGKPLVPIAPKPAPYVDPATGSP 388

  Fly   314 NYQPGQSSSNSGSNGSVSGSSSVPPTRS----SLPPPLVLSGSGIRYRQNAP-------GGVSGV 367
            ...||     :|:..|.....:||..::    |:|..|.:|..|.|... ||       |..:..
Mosquito   389 MLMPG-----NGALPSPMSKVNVPKQKAILHHSIPRNLAVSVPGSRISM-APLDHPEQVGPQTVR 447

  Fly   368 VRRTVVPNSVKTTGPVFHTINGFKVDLNSAAQQDSYRLPNGRLIQVKRQVP--QTIQPASTVPTP 430
            |..|....|...:.|::||..|:::||.:|:||.:||||||:||.|::|..  .....|.||.:|
Mosquito   448 VSSTAPRQSTGGSAPMYHTFEGYQIDLQAASQQSTYRLPNGKLILVRKQTADGSAQNAAETVISP 512

  Fly   431 PTPPALVVPQVGPGVVIRPRAPITTNR-----------------------------PSLHISTYG 466
            ..|     |:|.||:    ..||..||                             |:.|:....
Mosquito   513 VQP-----PKVAPGM----SGPIPGNRLLNNNVTSVPPGAAGGPMVVRNGQEMRRVPATHVQRQQ 568

  Fly   467 ------------SNMGIYNPQTNQQ--------------QRA----------------------- 482
                        :.|...|.|..||              |||
Mosquito   569 AMQHQQRVQMQMAQMAQQNDQYQQQFQRMQQRMDQRTTGQRAMAQRMQQQQQQQQQQQQQQQQLH 633

  Fly   483 -----PQVRVGNANPAPPPLQGLPPNANGGQTLMITPAP-QPAPKVPT--------------LVR 527
                 |.:.||   ||.|...|:...|.||....:.|.| |.||..|.              ||.
Mosquito   634 QQLPQPGMYVG---PAAPGAGGIVYPAAGGAAPAVVPVPVQQAPPSPAGNAQQPAILALLRGLVN 695

  Fly   528 LTFPNTPMGQARAQLQEQIFSAMDICTHLTGKVVSLTHSNAYNQVRSYLELKELYIHMSYLMTYA 592
            .....||:|.||...:.::.:..:||.|:.||:.|||:||::..:|:..:||||:||:||||||.
Mosquito   696 GPHEETPLGSARKDFEAKMLAGAEICHHILGKIYSLTNSNSFKNIRNLRDLKELFIHLSYLMTYG 760

  Fly   593 IGRFKNLQEKCLVDMREKGFKNDANSLENGQLAADKQASDD---EDNEIEIVEPKTDTITIDSDN 654
            |||||.|.|:|:.|:::.||..:::.:..|:...::...||   :|::.||:|..|..|.:|||:
Mosquito   761 IGRFKTLHERCVDDVKKMGFTKESDFVMMGERVNNRNPEDDNSEDDDDCEIIEQNTTVIEVDSDD 825

  Fly   655 EDDMPSTSTATQQEQPQETA----------------------------------IMKITSVTSEA 685
            |    :.|||.:::...|.|                                  ..|:|.|:...
Mosquito   826 E----AASTAGKEKAATEGAAGGSSAKKAPKTVAQPAAPKDGPANTLTVGEIVVTWKVTGVSDTP 886

  Fly   686 SKKELQENNQ------ADIDVAAFSSTILASLLEVEVNEGASEPKPVSPGQKKQPRKKTTNKPN- 743
            .:.:....|.      |:.|..|.:..|:.:  ..:....|:...|...|..:.....|::|.:
Mosquito   887 GQTQTPAQNDKEGPRAANTDNVAVAGEIVVA--PKKTTPAAAAATPAGEGSNENASHDTSDKDSN 949

  Fly   744 ----------------------PALLQLERQRMEDMKKSDAKLKMKVMVKLKRAEDEFEVARKWV 786
                                  ..:..:|.:....:..|:..:...:..||...:.. |||....
Mosquito   950 NTVEVTIEALNSSGTGNLSSSTETMEMMETEANNSVTDSEGPVVSALPNKLTATQTP-EVASPGN 1013

  Fly   787 EDM-----------------KQGQELATKIKDSKAATPSN-KTQKPSENLKISEKGSSAKKESTK 833
            ||:                 |:..||......|.|||..: ::::..|:::|::...:.:..|:.
Mosquito  1014 EDIDLGAADKDEVEMIEISDKEVSELLDIHASSNAATEKDAQSEQKDESIEITDSDDAGQNGSST 1078

  Fly   834 QHGEGDKENTKNKEKIGDILKAAIKAKIGENEKLMAEDVQLPVDELLTEKDKELDKETLTSTEPE 898
            :..|..||..:|...:.                  |:|..    |.|:: ||..|.|...|.:..
Mosquito  1079 EKSEAGKEAAENATTVS------------------ADDTV----ETLSD-DKSADAELDASDQKA 1120

  Fly   899 TNKKSGTEKGS--DKKQHLTKENNVK----GESKDESKTDQKSDCKKG-----PDSECTEIEEET 952
            .:..:.|:|.|  |..:..:||::.:    .::.|:|.....||.:.|     |||..|.
Mosquito  1121 DDATTCTDKASLPDDMEQSSKESSSEVLDLMDAADDSYHSDSSDIQFGAECDAPDSAATH----- 1180

  Fly   953 EMLSEKGYGGSEKEQGDTENMEDETSSERPTLIGEIEK--NLLKEGKEESSEKFDKE-VEPSKDV 1014
                :.|..|......::|....|:...:|:|..|.:|  .:....:.|.|::.:|: ||||..:
Mosquito  1181 ----KDGNAGESSSVKNSEPKTGESDKNKPSLPSETKKGETVGSTNEAEISKQQEKQAVEPSAVI 1241

  Fly  1015 GKDSPTTQGKGQDSDKLKNARAGLKNSTQDASNTVEPPVAASNE--------------------- 1058
            ..|:.:|:..|..|...::|.|..|:   |.::|.|...|..||
Mosquito  1242 DLDASSTESDGNKSATEEDADASKKS---DDASTKEDDTATKNESVTTKQQEKSEATAEPSAIID 1303

  Fly  1059 --------NDQSSVGELIERMDVTELDEKP---KELLDCALDEVI-------PME----GIELSD 1101
                    :|..|..|  |.:|.:..|.:|   :|:.:...:|.|       |.|    |:|:||
Mosquito  1304 LDASSTESSDNKSATE--EDVDASNKDSEPTVQEEISEICTNESIDESLMTDPAEPETAGVEVSD 1366

  Fly  1102 D-------------TEDLIKALG--------SPSVLPSQNTKDNETDLDANDFIGNLPLETTEPP 1145
            :             .|::.:.:|        ..|.|.||   :.||..|:.:.:|..|.|
Mosquito  1367 NKEESTDNPKVQEVAEEIEEVVGENVDTTSDGSSELQSQ---EKETPDDSAEVVGCEPAE----- 1423

  Fly  1146 EILLKEDECKVEKTTG--ISQVGAPSPAENG-----DTEM----------------EST-LEASD 1186
            :|:..||:....||:.  ::....|...|:|     |.|:                ||| ::||:
Mosquito  1424 KIVSGEDDVVSAKTSSEPVNSNSEPMDTEDGQLSCNDAEVMDVTEEQERPSSSHGQESTEMDASE 1488

  Fly  1187 SAPDE 1191
            ....|
Mosquito  1489 GMEQE 1493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADD1	NP_725094.1	ADDz_ATRX	62..164	CDD:277252	73/101 (72%)
		PTZ00121	<720..1057	CDD:173412	78/391 (20%)
LOC1280894	XP_061510381.1	None