Protein Alignment Hectd1 and UFD4

DIOPT Version :10

• Sequence 1: NP_001406767.1
• Gene: Hectd1 / 362736
• RGDID: 1561653
• Length: 2610
• Species: Rattus norvegicus
• Sequence 2: NP_012915.3
• Gene: UFD4 / 853859
• SGDID: S000001493
• Length: 1483
• Species: Saccharomyces cerevisiae
• Alignment Length: 1311
• Identity: 311/1311 - (23%)
• Similarity: 508/1311 - (38%)
• Gaps: 347/1311 - (26%)

  Rat  1421 DVHEPIVVLSSAENVP----------QTEVGSSSSASTSTLTAETG--------------SENAE 1461
            |:.|.||.|.|.::.|          .|.:..||...:..|..:|.              |.||.
Yeast   388 DLIERIVQLVSIQDTPLENKLKCLDILTVLAMSSDVLSRELREKTDIVDMATRSFQHYSKSPNAG 452

  Rat  1462 RKLGPDSSVRAPGE-SSAISMGIVSVSSPDVSSVSELTNKEAASQRPLSSSASNRLSVSSLLAAG 1525
            ..   ::.:..|.. ..:||..||.:..|:...:.........|.|.:   .||:....||:
Yeast   453 LH---ETLIYVPNSLLISISRFIVVLFPPEDERILSADKYTGNSDRGV---ISNQEKFDSLV--- 508

  Rat  1526 APMSSSASVPNLSSRETSSLESFVRRVANIARTNATNNMNLSRSSSDNNTNTLGRNVMSTATSPL 1590
                 ...:|.|....|::.:..|||...||.....:.:|.|.:.:.|:      .::....|.|
Yeast   509 -----QCLIPILVEIYTNAADFDVRRYVLIALLRVVSCINNSTAKAIND------QLIKLIGSIL 562

  Rat  1591 MGAQSFPNLTTPGTTSTVTMSTSSVTSSSNVATATTVLSVGQSLSNTLTTSLTSTSSESDTGQEA 1655
            ...:              |.|.::.|.||.   |.|:|..|.||.:.:....:.....| ..:|.
Yeast   563 AQKE--------------TASNANGTYSSE---AGTLLVGGLSLLDLICKKFSELFFPS-IKREG 609

  Rat  1656 EYSLYDFLDSCRASTLLAELDDDEDLPEPDEEDD-----ENEDDNQEDQEYE------------- 1702
            .:.|...| |...:.:..:.|.:|::...|||.|     |..|:..|:.:||
Yeast   610 IFDLVKDL-SVDFNNIDLKEDGNENISLSDEEGDLHSSIEECDEGDEEYDYEFTDMEIPDSVKPK 673

  Rat  1703 --EVMILRRPSLQ----------RRAGSRSDVTHHAVTSQLPQVPSGAG-----SRPIGEQEEEE 1750
              .:.|.|..||.          .|..|:.:|...|:|.:|.|:.....     |.|  ::.||:
Yeast   674 KISIHIFRTLSLAYIKNKGVNLVNRVLSQMNVEQEAITEELHQIEGVVSILENPSTP--DKTEED 736

  Rat  1751 YETKGGRRRTWD--------DDY---------------VLKRQFSALVPAFDPRPGRTNV-QQTT 1791
            :  ||    .|.        :|:               :.||..|:.|..|........| :...
Yeast   737 W--KG----IWSVLKKCIFHEDFDVSGFEFTSTGLASSITKRITSSTVSHFILAKSFLEVFEDCI 795

  Rat  1792 D--LEIPPPGTPHSELLEEVEC---------TPSPRLALTLKVTGLGTTREVELPLSNFRSTIFY 1845
            |  |||........|....|:|         :.:..:.:.|...|..:...:...||   |||
Yeast   796 DRFLEILQSALTRLENFSIVDCGLHDGGGVSSLAKEIKIKLVYDGDASKDNIGTDLS---STI-- 855

  Rat  1846 YVQKLLQLSCNGNVKS--DKLR------RIWEPTYTIMYREMKDSDKEKENGKMGCWSIEHVEQY 1902
                 :.:.|..:..|  :.||      |........:.....::|:|:|...:.....::.:.:
Yeast   856 -----VSVHCIASFTSLNEFLRHRMVRMRFLNSLIPNLTSSSTEADREEEENCLDHMRKKNFDFF 915

  Rat  1903 LGTDELPKNDLI------TYLQKNADAAFLRHWKLTGTNKSIRKNRNCSQLIAAYKDFC---EHG 1958
            ...:::.....:      |::::|.|...|  |..|.|.|                 ||   |..
Yeast   916 YDNEKVDMESTVFGVIFNTFVRRNRDLKTL--WDDTHTIK-----------------FCKSLEGN 961

  Rat  1959 TRSGLNQGASSSLQSSDILNLTKEQPQAKAGNGQNPCGVEDVLQLLRILYIVASDPYSRISQEDG 2023
            .|.  ::.|..:.:...:.:..|::..|:...|.:    .|:|.||..|:...
Yeast   962 NRE--SEAAEEANEGKKLRDFYKKREFAQVDTGSS----ADILTLLDFLHSCG------------ 1008

  Rat  2024 DEQPQFTFPPDEFTSKKITTKILQQIEEPLALASGALPDWCEQLTSKCPFLIPFETRQLYFTCTA 2088
                   ...|.|.:.|::.|:.:|::|||.:||||||||...||.:.|||.||:||.|:..||:
Yeast  1009 -------VKSDSFINSKLSAKLARQLDEPLVVASGALPDWSLFLTRRFPFLFPFDTRMLFLQCTS 1066

  Rat  2089 FGASRAIVWLQNRREATVERTRTTSSVRRDDPGEFRVGRLKHERVKVPRGESLMEWAENVMQIHA 2153
            ||..|.|...:|:.:.        |...|:|....::||:...::::.| :::......::..:.
Yeast  1067 FGYGRLIQLWKNKSKG--------SKDLRNDEALQQLGRITRRKLRISR-KTIFATGLKILSKYG 1122

  Rat  2154 DRKSVLEVEFLGEEGTGLGPTLEFYALVAAEFQRTDLGTWLC---------DDNFPDDESRHVDL 2209
            ....|||:|:..|.|||||||||||::|:..|.|..|..|.|         |.:..||
Yeast  1123 SSPDVLEIEYQEEAGTGLGPTLEFYSVVSKYFARKSLNMWRCNSYSYRSEMDVDTTDD------- 1180

  Rat  2210 GGGLKPPGYYVQRSCGLFTAPFPQDSDELERITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLM 2274
                     |:  :..||..|....|:. |::.:||.:||.|:|:.:.|||::|...||.||:|
Yeast  1181 ---------YI--TTLLFPEPLNPFSNN-EKVIELFGYLGTFVARSLLDNRILDFRFSKVFFEL- 1232

  Rat  2275 CMGDIKSNMSKLIYESRGDRDLHCTESQSEASTEEGHDSLSVGSFEEDSKSEFILDPPKPKPPAW 2339
                                 ||      ..||.      :|.:...|.::..::
Yeast  1233 ---------------------LH------RMSTP------NVTTVPSDVETCLLM---------- 1254

  Rat  2340 FNGILTWEDFELVNPHRARFLKEIKDLAIKRRQILGNKSLSEDEKNTKLQELVLKNPSGSGPPLS 2404
                     .|||:|..|:.||          .|:.||    |:.                  ::
Yeast  1255 ---------IELVDPLLAKSLK----------YIVANK----DDN------------------MT 1278

  Rat  2405 IEDLGLNFQFCPSSRIYGFTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDGF 2469
            :|.|.|.|      .:.|...::|.|.|.::.:...|.|||:..:.|..:..||:||::||.:||
Yeast  1279 LESLSLTF------TVPGNDDIELIPGGCNKSLNSSNVEEYIHGVIDQILGKGIEKQLKAFIEGF 1337

  Rat  2470 NKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRFVRVLCGMSSDE 2534
            :|||..|::.....:|:..|. |.....|:...:......:.|||.||.....|:.::......|
Yeast  1338 SKVFSYERMLILFPDELVDIF-GRVEEDWSMATLYTNLNAEHGYTMDSSIIHDFISIISAFGKHE 1401

  Rat  2535 RKAFLQFTTGCSTLPPGGLANLHPRLTVVRKVD----ATDASYPSVNTCVHYLKLPEYSSEEIMR 2595
            |:.||||.||...||.||..:|:|:.|||.|..    ..|...|||.||.:|||||:|:|::|||
Yeast  1402 RRLFLQFLTGSPKLPIGGFKSLNPKFTVVLKHAEDGLTADEYLPSVMTCANYLKLPKYTSKDIMR 1466

  Rat  2596 ERLLAATMEKG 2606
            .||..| :|:|
Yeast  1467 SRLCQA-IEEG 1476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hectd1	NP_001406767.1	ANKYR	<366..>479	CDD:440430
		ANK repeat	366..393	CDD:293786
		ANK repeat	396..426	CDD:293786
		ANK repeat	428..457	CDD:293786
		Sad1_UNC	1107..1240	CDD:400199
		MIB_HERC2	1277..1335	CDD:461991
		BTHB_HectD1	1893..1958	CDD:439138	11/73 (15%)
		HECTc	2131..2608	CDD:238033	138/489 (28%)
UFD4	NP_012915.3	HUL4	581..1482	CDD:227354	265/1081 (25%)