Protein Alignment Hectd1 and Ufd4

DIOPT Version :9

• Sequence 1: XP_006240148.1
• Gene: Hectd1 / 362736
• RGDID: 1561653
• Length: 2610
• Species: Rattus norvegicus
• Sequence 2: NP_609369.1
• Gene: Ufd4 / 34378
• FlyBaseID: FBgn0032208
• Length: 2727
• Species: Drosophila melanogaster
• Alignment Length: 2899
• Identity: 1398/2899 - (48%)
• Similarity: 1793/2899 - (61%)
• Gaps: 461/2899 - (15%)

  Rat     1 MADVDPDTLLEWLQMGQGDERDMQLIALEQLCMLLLMSDNVDRCFETCPPRTFLPALCKIFLDES 65
            |.||||:||||||.||||||||||||||||||||||||||||||||:|||||||||||||||||.
  Fly     1 MGDVDPETLLEWLSMGQGDERDMQLIALEQLCMLLLMSDNVDRCFESCPPRTFLPALCKIFLDEL 65

  Rat    66 APDNVLEVTARAITYYLDVSAECTRRIVGVDGAIKALCNRLVVVELNNRTSRDLAEQCVKVLELI 130
            ||:|||||||||||||||||||||||||.:||||||:||.|||.:|::||||||||||:||||||
  Fly    66 APENVLEVTARAITYYLDVSAECTRRIVSIDGAIKAICNHLVVADLSSRTSRDLAEQCIKVLELI 130

  Rat   131 CTRESGAVFEAGGLNCVLTFIRDSGHLVHKDTLHSAMAVVSRLCGKMEPQDSSLEICVESLSSLL 195
            ||||:|||||.|||||||:||||.|..||||||||||:||||||.|:||....::.||||||:||
  Fly   131 CTREAGAVFEGGGLNCVLSFIRDCGSQVHKDTLHSAMSVVSRLCTKVEPNTPCIQNCVESLSTLL 195

  Rat   196 KHEDHQVSDGALRCFASLADRFTRRGVDPAPLAKHGLTEELLSRMAAAGG------TVSG--PSS 252
            :|||..||||||:||||:||||||:.|||||||::|||.|||.|:.:.||      |.:|  |:|
  Fly   196 QHEDPMVSDGALKCFASVADRFTRKWVDPAPLAEYGLTTELLKRLQSVGGNTHSSLTAAGTQPTS 260

  Rat   253 ACKPGRSTTG---APSAAADSKLSN--------------QVSTIVSLLSTLCRGSPLVTHDLLRS 300
            :.:|..:|..   ..:.|..:.:||              .:||.:|||||||||||.:|||:|||
  Fly   261 SSQPAATTNSDAINENVAGTATISNSTKVKSSDAAASPQSISTTISLLSTLCRGSPSITHDILRS 325

  Rat   301 ELPDSIESALQGDERCVLDTMRLVDLLLVLLFEGRKALPKSSAG-STGRI-PGLRRLDSSGERSH 363
            :|.|::|.|||||||||||.||..||||:||||||:||.:.|.. :.|:: |..||.:::.:|:|
  Fly   326 QLADALERALQGDERCVLDCMRFADLLLLLLFEGRQALNRGSNNPNQGQLAPRPRRNNTNTDRTH 390

  Rat   364 RQLIDCIRSKDTDALIDAIDTGAFEVNFMDDVGQTLLNWASAFGTQEMVEFLCERGADVNRGQRS 428
            |||||||||||::||.:||::|..:||.|||||||||||||||||.||||:|||:|||||:||||
  Fly   391 RQLIDCIRSKDSEALREAIESGGIDVNCMDDVGQTLLNWASAFGTLEMVEYLCEKGADVNKGQRS 455

  Rat   429 SSLHYAACFGRPQVAKTLLRHGANPDLRDEDGKTPLDKARER---GHSEVVAILQSPGDWMCP-- 488
            ||||||||||||.:||.||:.||.||||||||||||||||||   ||.||.|||||||:||.|
  Fly   456 SSLHYAACFGRPAIAKILLKFGAYPDLRDEDGKTPLDKARERLDDGHREVAAILQSPGEWMSPDH 520

  Rat   489 --VNKGDDKKKKDTNKDEEECNEPKGDPEMAPVYLKRLLPVFAQTFQHTMLPSIRKASLALIRKM 551
              :|| |.||        ....||:|||||||:|||.|||:|.:||..:||.|:|:||||||:|:
  Fly   521 SLLNK-DGKK--------YTLMEPRGDPEMAPIYLKVLLPIFCRTFLGSMLGSVRRASLALIKKI 576

  Rat   552 IHFC--------SEALLKEVCDSDAGHNLPTALVEITATVLDQEDDDDGHLLALQIIRDLVDKGG 608
            :.:.        ||....|...|.:|.|....|:|:.|:|||.|||.||||:.|.||.:::.|..
  Fly   577 VQYAYPTVLQSLSETSFSEDAASTSGQNGGNLLIEVIASVLDNEDDGDGHLIVLNIIEEIMCKTQ 641

  Rat   609 DIFLDQLARLGVISKVSALAGPSSDD-------ENEEESKPEK------------EDEPQEDAKE 654
            :.|||..|||||.:||.||....:::       ..||.:..::            .|:|.|||||
  Fly   642 EEFLDHFARLGVFAKVQALMDTDAEELYVQLPGTVEEPAAAQRSSTSVVVAPRPTSDDPMEDAKE 706

  Rat   655 LQQGKPYHWRDWSVIRGRDCLYIWSDAAALELSNGSNGWFRFILDGKLATMYSSGSPEGGSDSSE 719
            :.||||||||:||:.|||||||:|||:.|||||||||||||||:||||||||||||||.|:||||
  Fly   707 ILQGKPYHWREWSICRGRDCLYVWSDSVALELSNGSNGWFRFIIDGKLATMYSSGSPENGNDSSE 771

  Rat   720 SRSEFLEKLQRARGQVKPSTSSQPILSAPGPTKLTVGNWSLTCLKEGEIAIHNSDGQQATILKED 784
            :|.||||||.|||..|.....|||||......:|.||||.|...|..::.|||::|.|.|:|::|
  Fly   772 NRGEFLEKLMRARSCVIAGVVSQPILPTASALRLVVGNWVLQSQKTNQLQIHNTEGHQVTVLQDD 836

  Rat   785 LPGFVFESNRGTKHSFTAETSLGSEFVTGWTGKRGRKLKSKLEKTKQKVRTMARDLYDDHFKAVE 849
            ||||:|||||||||:|:|||.||.:|.:||:..:.::.|||.|..|.:||.::|::|:.:||:.:
  Fly   837 LPGFIFESNRGTKHTFSAETVLGPDFASGWSTAKKKRNKSKTEGQKFQVRNLSREIYNKYFKSAQ 901

  Rat   850 SMPRGVVVTLRNIATQLESSWELHTNRQCIEGENTWRDLMKTALENLIVLLKDESTISPYEMCSS 914
            .:|||.|..|.:|..|:|.|:|    .|.:.....|...:..||..|..|:.::..:|.|||.||
  Fly   902 IIPRGAVAILTDIVKQIELSFE----EQHMAPNGNWETTLTDALMKLSQLIHEDGVVSAYEMHSS 962

  Rat   915 GLVQALLTVLNSSIDLDMKQDCSQ---LVERINVFKTAFSES--EDDESRP-----AVALIRKLI 969
            ||||||:.||:.:........|.:   ..:|::|||....|.  |...::|     |..||:||:
  Fly   963 GLVQALVAVLSVNHWETNSPRCKRNKMQKQRVSVFKKCILEDNVESATNKPRTKSTASILIQKLV 1027

  Rat   970 AVLESIERLPLHLYDTPGSTYNLQILTRRLRFRLERAPGETALIDRTGRMLKMEPLATVESLEQY 1034
            :||||.|:||::|||:|.:.|:||||.:|||||||||..|:.|.||:||.||||||||:..|.:|
  Fly  1028 SVLESTEKLPVYLYDSPCTGYSLQILQKRLRFRLERAECESTLFDRSGRTLKMEPLATIGQLSKY 1092

  Rat  1035 LLKMVAKQWYDFDRSSFVFVRKLREGQN-FIFRHQHDFDENGIIYWIGTNAKTAYEWVNPAAYGL 1098
            |||||||||||.|||::.:::|:||.:. .:|.|..||||.|::::||:||||. :|||||.|||
  Fly  1093 LLKMVAKQWYDLDRSTYFYLKKIREHRTATVFTHSFDFDEEGLLFYIGSNAKTC-DWVNPAQYGL 1156

  Rat  1099 VVVTSSEGRNLPYGRLEDILSRDNSALNCHSNDDKNAWFAIDLGVWVIPSAYTLRHARGYGRSAL 1163
            |.||||||:.||||:||||||||:.:||||:.|:|.|||||||||::||:|||||||||||||||
  Fly  1157 VQVTSSEGKTLPYGKLEDILSRDSISLNCHTKDNKKAWFAIDLGVYIIPTAYTLRHARGYGRSAL 1221

  Rat  1164 RNWVFQVSKDGQNWTSLYTHVDDCSLNEPGSTATWPLDPAKDEKQGWRHVRLKQMGKNASGQTHY 1228
            |||:.|.||||..||:|.|||||.||.|||||||||::.|.|:...:||:|::|.|:||||||||
  Fly  1222 RNWLLQGSKDGSTWTTLSTHVDDKSLVEPGSTATWPINCATDDSVWYRHIRIQQNGRNASGQTHY 1286

  Rat  1229 LSLSGFELYGTVNGVCEDQLGKAAKEAEANLRRQRRLVRSQVLKYMVPGARVIRGLDWKWRDQDG 1293
            |||||||:||.|.||.:| :||:.|||||..||:||.:|:| ||:|..|||||||:||:|.:|||
  Fly  1287 LSLSGFEIYGRVVGVADD-IGKSVKEAEAKTRRERRQIRAQ-LKHMTTGARVIRGVDWRWEEQDG 1349

  Rat  1294 SPQGEGTVTGELHNGWIDVTWDAGGSNSYRMGAEGKFDLKLA-----PGYD-------PDTVASP 1346
            .  .|||:|||:|||||||.||.|..||||||||||:|||||     ..:|       ..|.|.|
  Fly  1350 C--AEGTITGEIHNGWIDVKWDHGVRNSYRMGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAKP 1412

  Rat  1347 -----KPVSSTVSGTTQSW-SSLVKNNCPDKTSAAAGSSSRKGSSSSVCSVAS-----------S 1394
                 ..::|..|.:|.|. .:..||..|:..|....|:.......:|.::|.           |
  Fly  1413 SEKGGNTLTSRKSSSTPSLPEATEKNQNPEGASNQTVSADNLAWKQTVETIAENVFASAKTQIIS 1477

  Rat  1395 SDISLG-STKTERRSE------IVMEHSIVSG-ADVHEPIVVLS--SAENVPQTEVGSSSSASTS 1449
            :.:::. |:..|.|::      ..|....:|| :.:...:..:|  ||.|.....:.||:.:..:
  Fly  1478 NQLAMNTSSSREARAKHKESGTNQMHKDNISGPSPLSRELEHISDLSAINNSMPAINSSNVSDLA 1542

  Rat  1450 TLT-----AETGSENAERKLGPDSSVRAPGESSAISMGIVSVSSPDVSSVS-------------- 1495
            |::     .|...||..|.|.|...   |.||...|.   |.|.|||.|.|
  Fly  1543 TISENLSLTELSKENICRVLTPSYK---PAESVTASQ---SSSHPDVQSSSPRENDIKNISNIEE 1601

  Rat  1496 ----------------------------------------------------------------- 1495
                                                                             
  Fly  1602 NNKMNANNSVNKISKDLLANLRTSNIAGCPPVTQLSTEALEMIDKMRDGVDMIRNMSNSILSTDT 1666

  Rat  1496 -------------------ELTNKEAASQR---------PLSSS---------ASNRLSVSSLL- 1522
                               .|.|.:.|:|:         |..||         |....:|.|::
  Fly  1667 FPVPCTNVPVGGKKTPKAQALINPDNANQKQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVD 1731

  Rat  1523 ---------AAGAPMSSSASVPNLSSRETSSLES---------FVRRVANIAR------TNATNN 1563
                     ....|...|.|||||::...|.:.|         .:...|.|||      ||..:|
  Fly  1732 IKEQPISNENVSVPSQMSISVPNLTTTSASEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQDN 1796

  Rat  1564 M------NLSRSSSDNNTNT-LGRNVMSTA---------TSPLMGAQSFPNLTTPGTTSTVTMST 1612
            .      |::.....|.:.: ||.:|.|..         :..|..|||:|:|:: ..:..:..|.
  Fly  1797 QIMNAEANVNEHGDQNASGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSS-NNSENIAPSN 1860

  Rat  1613 SSVTSSSNVATATTVLSVGQSLSNTLTTSLTSTSSESDTGQEAEYSLYDFLDSCRASTLLAELDD 1677
            .|.||:...:.:|        :::|||.|||||||:|:     :.||.|||:||||..||.:|||
  Fly  1861 PSNTSAGQQSAST--------INHTLTMSLTSTSSDSE-----QVSLEDFLESCRAPALLGDLDD 1912

  Rat  1678 DEDLPEPDEEDDENEDDNQEDQEYEEVMILRRPSLQRRAGSRSDVTHHAVTSQLPQVPSGAGSRP 1742
            ::|:.| |.:::||||      ||||                       |.:.|.||........
  Fly  1913 EDDMDE-DNDEEENED------EYEE-----------------------VGNTLLQVMVSRNLLT 1947

  Rat  1743 IGEQEEEEYETKG-GRRRTWDDDYVLKRQFSALVPAFDPRPGRTNVQQTTDLEIPPPGT--PHSE 1804
            ..:.|..|....| .:|::|||::|||||||||:||||||||||||.||:||||.|.|.  |..:
  Fly  1948 FMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPLGAELPKPQ 2012

  Rat  1805 LLEEVECTPSPRLALTLKVTGLGTTREVELPLSNFRSTIFYYVQKLLQLSCNGNVKSDKLRRIWE 1869
            .....|....|.|.|.|:..|:|...|||:.|||...|||..||:|||  |:...|.||.|:|||
  Fly  2013 QSGGPETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDWTIFRAVQELLQ--CSQLNKLDKFRKIWE 2075

  Rat  1870 PTYTIMYREMKDSDKEKENGKMGCWSIEHVEQYLGTDELPKNDLITYLQKNADAAFLRHWKLTGT 1934
            |||||:|||:....:|..     |         |.::|.|:...:                   :
  Fly  2076 PTYTIVYREVSPEAQEST-----C---------LESEEFPQTPDV-------------------S 2107

  Rat  1935 NKSIRKNRNCSQLIAAYKDFCEHGTRSGLNQGASSSLQSSDILNLTKEQPQAKAGN--GQNPCGV 1997
            :||                            |||:         |:...|.....|  ..|.|.|
  Fly  2108 SKS----------------------------GAST---------LSPNSPMHIGFNVADNNLCSV 2135

  Rat  1998 EDVLQLLRILYIVASDPYSRISQEDGD----EQPQFTFPPDEFTSKKITTKILQQIEEPLALASG 2058
            :|||:||..:        :.::|.:.|    |........|.|.|||||.|:.|||::||.|||.
  Fly  2136 DDVLELLTQI--------NGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASN 2192

  Rat  2059 ALPDWCEQLTSKCPFLIPFETRQLYFTCTAFGASRAIVWLQNRREATVERTR-TTSSVRRDDPGE 2122
            |||:|||.|...||||.|||||||||.||:|||||:||.||::|:.||||.| ...|.|||| .|
  Fly  2193 ALPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDD-HE 2256

  Rat  2123 FRVGRLKHERVKVPRGESLMEWAENVMQIHADRKSVLEVEFLGEEGTGLGPTLEFYALVAAEFQR 2187
            ||:||||||||||||.|.|:.||..||:.|.:||||||||||.|||||||||||||||||||.||
  Fly  2257 FRIGRLKHERVKVPRNEDLLMWAMQVMKTHCNRKSVLEVEFLDEEGTGLGPTLEFYALVAAEIQR 2321

  Rat  2188 TDLGTWLCDDNFPDD-ESRHVDLGGGLKPPGYYV-QRSCGLFTAPFPQDSDELERITKLFHFLGI 2250
            :||..|||||:..:| |:......|..||.|||| :|..|:|.||.||:|:..|.:.|.|.|.|:
  Fly  2322 SDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQNSEICENVLKYFWFFGV 2386

  Rat  2251 FLAKCIQDNRLVDLPISKPFFKLMCMGDIKS-NMSKLIYESR-GDRDLHCTESQSEASTEEGHDS 2313
            |:||.:||.||||:|:|..|.:|:|...:.| |:.|:|.:.| ||
  Fly  2387 FVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGD-------------------- 2431

  Rat  2314 LSVGSFEED--SKSEFILDPPKPKPPAWFNGILTWEDFELVNPHRARFLKEIKDLAIKRRQILGN 2376
            |||.|.:.|  .....:|.....|..| |.|||:.|:.:.::|.|.:||:|:::|.::::.|..:
  Fly  2432 LSVVSEDSDIVETCTKLLRTDSNKSNA-FGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFD 2495

  Rat  2377 KSLSEDEKNTKLQELVLKNPSGSGPPLSIEDLGLNFQFCPSSRIYGFTAVDLKPSGEDEMITMDN 2441
            .::|.::|:..:.||.|:..:|.  .:|:|||.|.|.:.|||.|||:|..:|.|:|....:|:||
  Fly  2496 DTISAEKKHELINELKLQTQNGL--EVSLEDLALTFTYLPSSSIYGYTQAELLPNGSSVNVTIDN 2558

  Rat  2442 AEEYVDLMFDFCMHTGIQKQMEAFRDGFNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINY 2506
            .|.|.:|:.:|.:..||.:||:||.||||:|||::||::|:..|.:|::||.|.|.|:.||||:|
  Fly  2559 LEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGEQFPHWSREDIISY 2623

  Rat  2507 TEPKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKVDATDA 2571
            |||||||.:|||||.|||.||..||.||||||||||||||:|||||||||||||||||||||...
  Fly  2624 TEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANLHPRLTVVRKVDAGVG 2688

  Rat  2572 SYPSVNTCVHYLKLPEYSSEEIMRERLLAATMEKGFHLN 2610
            |||||||||||||||:|.:||||:||||.||.|||||||
  Fly  2689 SYPSVNTCVHYLKLPDYPTEEIMKERLLTATKEKGFHLN 2727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hectd1	XP_006240148.1	Ank_2	366..457	CDD:289560	70/90 (78%)
		ANK repeat	366..393	CDD:293786	16/26 (62%)
		ANK	369..479	CDD:238125	87/112 (78%)
		ANK repeat	396..426	CDD:293786	25/29 (86%)
		ANK repeat	428..457	CDD:293786	22/28 (79%)
		F5_F8_type_C	1107..1240	CDD:304887	95/132 (72%)
		MIB_HERC2	1277..1335	CDD:284184	42/57 (74%)
		HECTc	2131..2608	CDD:238033	255/482 (53%)
		HECTc	2155..2607	CDD:214523	240/457 (53%)
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786	16/26 (62%)
		ANK	396..509	CDD:238125	87/112 (78%)
		ANK repeat	422..453	CDD:293786	26/30 (87%)
		ANK repeat	455..484	CDD:293786	22/28 (79%)
		F5_F8_type_C	1173..1298	CDD:329041	90/124 (73%)
		MIB_HERC2	1333..1389	CDD:310955	42/57 (74%)
		DamX	1576..>1725	CDD:330571	15/151 (10%)
		HECTc	2265..2725	CDD:238033	255/482 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346098
Domainoid	1	1.000	625	1.000	Domainoid score	I168
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9115
Inparanoid	1	1.050	2238	1.000	Inparanoid score	I35
OMA	1	1.010	-	-		QHG52632
OrthoDB	1	1.010	-	-		D10145at33208
OrthoFinder	1	1.000	-	-		FOG0006411
OrthoInspector	1	1.000	-	-		oto95914
orthoMCL	1	0.900	-	-		OOG6_107049
Panther	1	1.100	-	-	LDO	PTHR45670
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4675
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770