DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hectd1 and SPAC12B10.01c

DIOPT Version :9

Sequence 1:XP_006240148.1 Gene:Hectd1 / 362736 RGDID:1561653 Length:2610 Species:Rattus norvegicus
Sequence 2:NP_594633.2 Gene:SPAC12B10.01c / 2541575 PomBaseID:SPAC12B10.01c Length:1647 Species:Schizosaccharomyces pombe


Alignment Length:1841 Identity:401/1841 - (21%)
Similarity:680/1841 - (36%) Gaps:525/1841 - (28%)


- Green bases have known domain annotations that are detailed below.


  Rat  1053 FVRKLREGQNFI-------------------FRH---QHDFDENGIIYWIGTNAKT-AYEWVNPA 1094
            |.:|.|..::|:                   .||   :|||.|  ::....|.:|| .::..|..
pombe    49 FTKKRRATKHFLKMEVSAKISEPPSSKSVEFGRHLNMRHDFSE--LLEQPLTTSKTRVFKSFNEK 111

  Rat  1095 AYGLVVVTSSEGRNLPYGRLEDILSRDNSALNCHSND---DKNAWFAI---DLGVWVIPSAYTLR 1153
            ..|...:..|:...||..:..|||:.....|:..|.|   ||.|...|   |..| :.|...|..
pombe   112 LKGKPQLVKSDKGVLPLNKQSDILNSYERVLSNASVDSALDKKAEVDIIPFDKSV-MEPKNITFN 175

  Rat  1154 HARG---YGRSALRNWV------FQVSKDGQNWTSLYTHV---------DDCSLNE------PGS 1194
            ...|   :|.|......      :..|.|...:.....||         ||.:.||      ...
pombe   176 DKSGLTKFGNSNSYETTYSDSSNYHTSTDSSQYNDQDDHVYDDTNDGTDDDINNNEYKDDESSSG 240

  Rat  1195 TATWPLDPAKDEKQGW-----------------RHVRLKQMGKNAS----GQTHYLSLSGFELYG 1238
            :.::..|...||::..                 ..:|.:....|.|    .:...:::||.|.|.
pombe   241 SESYERDEDVDEEEEEDDDENNDEGDDEDENENDELRSENGSPNPSAAVINEQENMNMSGIEEYD 305

  Rat  1239 TVNGVCEDQLGKAAKEAEANLRRQRRLVRSQVLKYMVPGARVIRGLDWKWRDQDGS--PQ----- 1296
            ..|.:.|             |.|.||..:.|.|...:..:..:...|    |:|.|  ||     
pombe   306 ETNLLNE-------------LGRIRRGNQFQSLASSILSSGNLENSD----DEDVSLGPQTYRFN 353

  Rat  1297 -----------GEGTVTGELHNG---WIDVTWDAGG----SNSYRMGAE----GKF--------- 1330
                       ..|...|.|..|   :.|.|.....    |.::.|..|    |.|         
pombe   354 SSFHPFRSAFSAPGVQFGRLLEGIKDFSDPTVQMLSLQELSEAFAMSTEDMLVGLFSTDSYIAAF 418

  Rat  1331 -DLKLAPGYDPDTVASPKPVSST--VSGTTQ---------SWSSLVKNNCP--------DKTSAA 1375
             ::.....||...|:....:|.|  ||...:         ::|.:|:..|.        |....|
pombe   419 SEILSGRNYDFGEVSIQLMLSCTTCVSNMMEALPLCMAKIAYSPIVRILCERMFDMQYIDIAEQA 483

  Rat  1376 AGSSSRKGSSSSVC--------------------------SVASSSDISLGSTKTERRSEIV-ME 1413
            .|...|......:|                          |:|::....|..:......||: :.
pombe   484 LGVLERLSKDFGICILEHRGMLAALQYFDFFYTTVQRTAISLAANCCKFLDESNASAAEEIIPLL 548

  Rat  1414 HSIVSGADVHEPIVVLSSAENVPQTEVGS------------SSSASTSTLTAETGSENAERKLGP 1466
            .:|:..:|.    :|:|.|.:..:|.:.|            |....|:.:.|.|.|.:..:.:..
pombe   549 SNILQSSDT----IVVSKAYSCLETIIESLKTSPNIIETIISEDLITTIVNALTNSTSQNKSMHL 609

  Rat  1467 D-------SSVRAPGESSAISMGIVSVSSPDV-------------SSVSELTNKEAASQRPLSSS 1511
            .       ||:..  .|||:.:..::.:.|||             |..:::...::....|:...
pombe   610 QVQLLHIISSLCQ--SSSALILPFLNHNLPDVMYEMLCGIPPSDTSHQADMITMQSLYYCPIELI 672

  Rat  1512 ASNRLSVSSLLAAGAPMSSSASVPNLSSRETSSLES-------------FVRRVANIARTNATNN 1563
            .:...:::|||    |.::|    |||....:.|..             |:..:.:|.....|..
pombe   673 ENLLRAITSLL----PKNTS----NLSDEFNTKLYRLNSILLTVVMDIYFIVPLHDIRSLAVTTA 729

  Rat  1564 MNLSRSSSDNNTNTLGRNV-MSTATSPLMGAQSFPNLTTPGTTSTVTMSTSSVTSSSNVATAT-- 1625
            :.:..|..:||.:.|..:: :|:..:.::.::...|..   ....:.|....:.:..||.::.  
pombe   730 LKMLCSIRENNLDGLVCSLPLSSFIASILNSRKSDNFL---KRDALEMCLFLLEALPNVYSSLFI 791

  Rat  1626 ---TVLSVGQSLSNT------LTTSLTSTSSESDTGQEAEYSLYDFLDSCRASTL--LAELDDDE 1679
               .|..||..:.:|      :..|::.:.::|....|...:|         |||  ||:    |
pombe   792 REGVVQEVGFLVRSTNADMKKIKLSISFSQNKSAARHEELKNL---------STLKSLAK----E 843

  Rat  1680 DLPEPDEEDDENE-------------DDNQEDQEYEEVMILRRPSLQRRAGSRSDVTHHAVTSQL 1731
            .|....||:.||.             .:.::|:.:.|        |.:.....|::|.|.:    
pombe   844 FLSNYKEENLENSTLVQLKQLSKHLLSETKQDESFSE--------LAKIFQEGSNITSHEL---- 896

  Rat  1732 PQVPSG------AGSRPIGEQEEEEYETKGGRRRTWDDDYVLKRQFSALVPAFDPRPGRTNVQQT 1790
              :.||      ...:..|......:..   ...|.|:..||:.....||..........:..:.
pombe   897 --LHSGLIHNLLLSLKKFGSSSLRTFLL---AMNTCDEREVLEFGNGPLVSLIFCLQNLLSTVEN 956

  Rat  1791 TDLEIPPPGTPHS-------ELLEEVECTPSPRL-----ALTLKVTGLGTTREVE------LPLS 1837
            ..|...||.|.::       :....:...|..|:     :|.:.:.||.|.|.::      :.:.
pombe   957 FQLSTLPPDTENAVDHVFSRQFKLRLMALPGSRIRPPFRSLVVSINGLATIRTLDNYLHSRISVR 1021

  Rat  1838 NFRSTIFYYVQKL--LQLSCNGNVK------SDKLRRIWEPTYTIMYREMKDSDKEKENGKMGCW 1894
            |.....|..:::.  |:.|.:|:.:      :|.:.:. .|.:|....|.:||.           
pombe  1022 NETGRRFSILREAGSLRESMSGSSRNSSGDYTDSMSQD-APNHTTEPSERRDSS----------- 1074

  Rat  1895 SIEHVEQY----LGTDELPKND-----LITYLQKNADAAFLRHWKLTGTNKSIRKNRNCSQLIAA 1950
            :..|.|::    |...::|:|.     |..|:|.:.|......||              :.:...
pombe  1075 TSSHFEEHFVFSLMGKKVPRNKTIFRILYEYIQLSDDHTLDDFWK--------------TPVPIF 1125

  Rat  1951 Y-KDFCEHGTRSGLNQGASSSLQSSDILNLTKEQPQAKAGNGQNPCGVEDVLQLLRILYIVASDP 2014
            | :..|.|....|             .||...|    ..|...|   :.::|.||.|||....|.
pombe  1126 YGEPDCIHNDMKG-------------ELNYENE----TEGFSIN---IREILDLLSILYYGIRDV 1170

  Rat  2015 YSRISQED--GDEQPQFTFPPDEFTSKKITTKILQQIEEPLALASGALPDWCEQLTSKCPFLIPF 2077
            ::....:.  |:.:...|    :|::.|::.|:.:|:||...:..|.||.||..|||..|||:||
pombe  1171 HTLFPDKHFRGNIENILT----DFSNWKLSAKLNRQLEEQQLVVHGCLPSWCISLTSAYPFLVPF 1231

  Rat  2078 ETRQLYFTCTAFGASRAIVWLQNRREATVERTRTTSSVRRDDPGEFRVGRLKHERVKVPRGESLM 2142
            |||.|....||||.||::.:|.:|..   |.::..||      ...:...|..:::::.| :.:.
pombe  1232 ETRYLLLQSTAFGLSRSVSFLLSRNP---ELSKNESS------SILQFVSLHRQKIRISR-KKIF 1286

  Rat  2143 EWAENVMQIHADRKSVLEVEFLGEEGTGLGPTLEFYALVAAEFQRTDLGTWLCDDNFPDDESRHV 2207
            .:|.:::..:|..:::||:|:..|.|:|||||||||..|:.||....|..|..|           
pombe  1287 NYALHLLATYAASENILEIEYEDEVGSGLGPTLEFYTSVSKEFTLNSLDIWRND----------- 1340

  Rat  2208 DLGGGLKPPGYYVQRSCGLFTAPFP--QDSDELERITKLFHFLGIFLAKCIQDNRLVDLPISKPF 2270
                  :|...:|.::.|||.:|.|  ..|.|.||...||..||.|:|:.|.|:|::.:..:..|
pombe  1341 ------QPNSKFVYQASGLFPSPIPLLGSSPENERKISLFFALGQFVARSIYDSRIISIQFNPLF 1399

  Rat  2271 FKLMCMGDIKSNMSKLIYESRGDRDLHCTESQSEASTEEGHDSLSVGSFEEDSKSEFILDPPKPK 2335
            |.                     |::..|.| |.|..::|                         
pombe  1400 FA---------------------RNIPLTIS-SVAKVDKG------------------------- 1417

  Rat  2336 PPAWFNGILTWEDFELVNPHRARFLKEIKDLAIKRRQILGNKSLSEDEKNTKLQELVLKNPSGSG 2400
                           |.|  ..|:|:::         |.|                  |||:.:.
pombe  1418 ---------------LAN--SLRYLEKL---------IPG------------------KNPTNAE 1438

  Rat  2401 PPLSIEDLGLNFQFCPSSRIYGFTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAF 2465
            ..:.:|||.|:|      .:.||.:::|.|.|....:|..|..:|::.:.|:.:..|:|:|:|||
pombe  1439 TDIKLEDLHLDF------TLPGFPSIELIPDGASTPVTTFNVSDYLNYVIDYTVGKGVQQQLEAF 1497

  Rat  2466 RDGFNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRFVRVLCGM 2530
            ::||:.|||...|...:..|: :.|.|.....|:...::.......|||.:||...|.:.::..|
pombe  1498 QNGFSSVFPYTSLQVLTEHEL-VTLFGTVDEDWSYATLMKSIVADHGYTMESPTIQRLLTLMSQM 1561

  Rat  2531 SSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKVD----ATDASYPSVNTCVHYLKLPEYSSE 2591
            :..|::.||||.||...||.||.|.|:|.|||||:::    ..|...|||.|||:|||||||||.
pombe  1562 NFQEQRDFLQFITGSRKLPIGGFAGLNPPLTVVRRLNEPPYVPDDYLPSVMTCVNYLKLPEYSSS 1626

  Rat  2592 EIMRERLLAATME--KGFHLN 2610
            |::..||..|.:|  ..|||:
pombe  1627 EVLGSRLSKAILEGQGSFHLS 1647

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hectd1XP_006240148.1 Ank_2 366..457 CDD:289560
ANK repeat 366..393 CDD:293786
ANK 369..479 CDD:238125
ANK repeat 396..426 CDD:293786
ANK repeat 428..457 CDD:293786
F5_F8_type_C 1107..1240 CDD:304887 37/183 (20%)
MIB_HERC2 1277..1335 CDD:284184 17/96 (18%)
HECTc 2131..2608 CDD:238033 137/484 (28%)
HECTc 2155..2607 CDD:214523 134/459 (29%)
SPAC12B10.01cNP_594633.2 HECTc 1276..1645 CDD:238033 137/484 (28%)
HECTc 1301..1642 CDD:214523 134/455 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45670
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
33.000

Return to query results.
Submit another query.