Protein Alignment Hectd1 and hecd-1

DIOPT Version :9

• Sequence 1: XP_006240148.1
• Gene: Hectd1 / 362736
• RGDID: 1561653
• Length: 2610
• Species: Rattus norvegicus
• Sequence 2: NP_001368365.1
• Gene: hecd-1 / 177486
• WormBaseID: WBGene00016405
• Length: 2650
• Species: Caenorhabditis elegans
• Alignment Length: 2933
• Identity: 1093/2933 - (37%)
• Similarity: 1518/2933 - (51%)
• Gaps: 606/2933 - (20%)

  Rat     1 MADVDPDTLLEWLQMGQGDERDMQLIALEQLCMLLLMSDNVDRCFETCPPRTFLPALCKIFLDES 65
            |..:||:|||||||.|.|||||:||:|||||||||||:||:|||||:||||||:|||||||:||:
 Worm     1 MDGIDPETLLEWLQTGIGDERDLQLMALEQLCMLLLMADNIDRCFESCPPRTFIPALCKIFIDET 65

  Rat    66 APDNVLEVTARAITYYLDVSAECTRRIVGVDGAIKALCNRLVVVELNNRTSRDLAEQCVKVLELI 130
            ||||||||||||||||||||.||||||..||||:||:|.||...::::|:|:||||||||:||.:
 Worm    66 APDNVLEVTARAITYYLDVSNECTRRITQVDGAVKAICTRLAAADISDRSSKDLAEQCVKLLEHV 130

  Rat   131 CTRESGAVFEAGGLNCVLTFIRDSGHLVHKDTLHSAMAVVSRLCGKMEPQDSSLEICVESLSSLL 195
            |.||:.||::|||:|.:||.:|..|..|||||:||||:||:||||||||.|..|..|.|||.:||
 Worm   131 CQRETMAVYDAGGINAMLTLVRVHGTQVHKDTMHSAMSVVTRLCGKMEPTDPELGKCAESLGALL 195

  Rat   196 KHEDHQVSDGALRCFASLADRFTRRGVDPAPLAKH-GLTEELLSRMAAAGGTVSGPSSACKPGRS 259
            :|||.:||:.||||||:|.|||.|:.:|||.||.| .|.|.|:|.|.|:               :
 Worm   196 EHEDPKVSESALRCFAALTDRFVRKMMDPAELAMHSNLVEHLISIMVAS---------------N 245

  Rat   260 TTGAPSAAADSKLSNQVSTIVSLLSTLCRGSPLVTHDLLRSELPDSI----ESALQGDERCVLDT 320
            ...:|:.|:    :|.:|.::||:..|||||.|:|..:|.|  |:.|    .:....:||.|.|.
 Worm   246 DENSPTTAS----ANILSIVLSLIGNLCRGSSLITEKVLTS--PNMITGLKATLTNKEERVVTDG 304

  Rat   321 MRLVDLLLVLLFEGRKALPKSSAGSTGRIPGLRRLDSSGERSHRQLIDCIRSKDTDALIDAIDTG 385
            :|..|||||||.|||.|||.:|..|.....|     |..||.||||||.||.||..||:|||::|
 Worm   305 LRFCDLLLVLLCEGRSALPLTSVVSGDYAAG-----SGAERVHRQLIDAIRQKDLTALVDAIESG 364

  Rat   386 AFEVNFMDDVGQTLLNWASAFGTQEMVEFLCERGADVNRGQRSSSLHYAACFGRPQVAKTLLRHG 450
            ..:|||.|||||:|.|||||||:.|||::||::|:|||:|.:|||||||||||||.|.|.||:.|
 Worm   365 QVDVNFADDVGQSLTNWASAFGSIEMVQYLCDKGSDVNKGHKSSSLHYAACFGRPDVVKLLLQRG 429

  Rat   451 ANPDLRDEDGKTPLDKARERG---HSEVVAILQSPGDWMCPVNKGDDKKKKDTNKDEEECNEPK- 511
            ||||||||||||.|||||||.   |::|..||:||..:|  .||.|.|.|..|:|......:|:
 Worm   430 ANPDLRDEDGKTALDKARERSDDDHNQVANILESPSAFM--RNKEDPKVKASTSKQPGTSTKPEL 492

  Rat   512 GDPEMAPVYLKRLLPVFAQTFQHTMLPSIRKASLALIRKMIHFCSEALLKEVCDSDA-----GHN 571
            .:|.:....|.:|||:|.:.||.::..|:|:.||:|:||::....:.....|.|.:|     ...
 Worm   493 PNPNLVRKVLHQLLPIFCEIFQKSLNGSVRRTSLSLMRKIVENIGDLRQSAVGDGNAPAAQSARK 557

  Rat   572 LPT-------ALVEITATVLDQEDDDDGHLLALQIIRDLVDKGGDIFLDQLARLGVISKVSALAG 629
            :.|       :||.:..:|:|||||.:||...|.|:..|::|..::::.:|.||||..:|.|:|.
 Worm   558 MSTDVSAGAESLVAVVVSVMDQEDDHEGHEQVLLILESLLEKDAELWVIELVRLGVFERVEAMAK 622

  Rat   630 -------------------------------------------------PSSDDENEEESK---- 641
                                                             |||....:.||.
 Worm   623 EPPKGLEEVLNAIHLEGRSRVTPMEIDFENQPSSSTAVPTANDIMDTTVPSSSGGADAESNSNPS 687

  Rat   642 ------PEKE----------DEPQEDAKE----------------------------------LQ 656
                  ||..          .:|:..|..                                  |.
 Worm   688 TIEMADPESSTPSSSTQQSISKPKATASSTASSAILQVVSKLSSVASLDKSAAAVDKKPTKTVLS 752

  Rat   657 QGKPYHWRDWSVIRGRDCLYIWSDAAALELSNGSNGWFRFILDGKLATMYSSGSPEGGSDSSESR 721
            ||.||.|::|.::||...|:||||...:||...||||||::.|......:.:|:.......:|..
 Worm   753 QGTPYRWKEWRIVRGTTSLFIWSDVLLIELPFQSNGWFRYLADNDSHVQFVTGTASVDQQMTEEE 817

  Rat   722 SEFLEKLQR---------ARGQVKPSTSSQPI--LSAPG-----PTKLTVGNWSLTCLKEGEIAI 770
            .:..:|.:|         .:|......||.||  |..|.     ..||.|..|.|...|..|:.|
 Worm   818 KDNFQKTERREMVSRWNAVKGVFDDDWSSVPIAVLGIPSNAKKVSQKLEVPAWELWSSKSSELQI 882

  Rat   771 HN-----SDGQQATIL-----KEDLPGFVFESNRGTKHSFTAETSLGSEFVTGWT--GKRGRKLK 823
            .:     ..||..|:|     ::|..||:||:..|.|.:...|.:|.|:|.|||:  |...||:|
 Worm   883 KSISSSAPTGQANTMLTTIKIQDDAGGFLFETGTGRKTNVMPEHALPSDFHTGWSSHGVSTRKMK 947

  Rat   824 SKLEKTKQKVRTMARDLYDDHFKAVESMPRGVVVTLRNIATQLESSWELHTNRQC---------- 878
            .:.:..|:||:.:|..|::||.|...:.||..:|.|.|.|..:||:.. |...|.
 Worm   948 FRQDIQKRKVQELAWKLWNDHLKEAHAKPREALVRLENAARTIESTIR-HVKAQSNFKHRNVKQP 1011

  Rat   879 -IEGENTWRDLMKTALENLIVLLKDESTISPYEMCSSGLVQALLTVLNSSIDLDMKQDCSQLVER 942
             ||....:...:.|..|:::    |:..:|.:|...||:|.||..:|:             ::|:
 Worm  1012 RIERVQEYCAAISTLHESIV----DDRRLSTFEFSVSGIVPALFGLLS-------------MMEK 1059

  Rat   943 I------NVFKTAFSESEDDESRPAVA-LIRKLIAVLESIERLPLHLYDTP-GSTYNLQILTRRL 999
            .      .:||..||:.|      |:: |..|::||||:.|:.|.||||:| ||::.||:|:||:
 Worm  1060 FPDSFPSRIFKEQFSKGE------ALSYLALKIVAVLEANEKFPQHLYDSPGGSSFGLQLLSRRV 1118

  Rat  1000 RFRLERAP-------GETALIDRTGRMLKMEPLATVESLEQYLLKMVAKQWYDFDRSSFVFVRKL 1057
            |.:||..|       .:..|:::||:::|.||||:|.::..||.:||.:||:|.:|:::.:|:::
 Worm  1119 RTKLEMLPRADGKENNDENLVNKTGKIVKCEPLASVGAIRAYLHRMVTRQWHDRERANYRYVKEI 1183

  Rat  1058 RE----GQNFIFRHQHDFDENGIIYWIGTNAKTAYEWVNPAAYGLVVVTSSEGRNLPYGRLEDIL 1118
            :|    |::...||..||||||:|||||||.:.|..|.|||....|.:|.|:.|. |:|:.||:|
 Worm  1184 QELKTKGKSIELRHVSDFDENGVIYWIGTNGRAAPLWTNPATVKAVKITCSDTRQ-PFGKPEDLL 1247

  Rat  1119 SRDNSALNCHSNDDKNAWFAIDLGVWVIPSAYTLRHARGYGRSALRNWVFQVSKDGQNWTSLYTH 1183
            |||.:.:|||::|||||.|.||||::|:|::|:|||:|||||||||||:.|.|.|.:.|.::..|
 Worm  1248 SRDQNPINCHTSDDKNAHFTIDLGLFVVPTSYSLRHSRGYGRSALRNWMLQGSVDAKRWENVIVH 1312

  Rat  1184 VDDCSLNEPGSTATWPLDPAKDEK--QGWRHVRLKQMGKNASGQTHYLSLSGFELYGTV-----N 1241
            .||..|.||||||||.:    .||  ..:|..|:.|.|||:||||||||.||||:||.:     .
 Worm  1313 TDDKGLGEPGSTATWHV----GEKGTTAFRFFRIAQNGKNSSGQTHYLSCSGFEIYGDIVDVVTE 1373

  Rat  1242 GVCED------QLGKAAKEAEANLRRQRRLVRSQVLKYMVPG----------------------- 1277
            .:|||      ..|.::....::......|.:.|||: |:|.
 Worm  1374 AICEDPPKKDSPAGTSSTPGSSSSAALPPLTKEQVLE-MLPARENNNRLKSGLSLETVTSMLQRS 1437

  Rat  1278 --------------ARVIRGLDWKWRDQDGSPQGEGTVTGELHNGWIDVTWDAGGSNSYRMGAEG 1328
                          ::|:||.||:|.||||.....|.:|....:||:|||||.|.:||||.||.|
 Worm  1438 RHRSRGSYKISESKSKVVRGKDWRWEDQDGGEGKFGRITSPPESGWVDVTWDNGNANSYRFGANG 1502

  Rat  1329 KFDLKLAPG----YDPDTVAS------------------PK----PVSSTVSGTTQSWSS----- 1362
            .||::....    |...::||                  ||    |.||:|.||:.|..|
 Worm  1503 NFDIERVTSTGHRYSTPSLASHVPTSVMEAVRRNRAFYTPKTTGGPPSSSVFGTSSSAGSSRGAA 1567

  Rat  1363 -------LVKNNCPDKTSAAAGSSS-----------------RKGSSSSVCS---VASSSDISLG 1400
                   .|||..|..|.::.|||.                 :|.|..||.|   .||:..:...
 Worm  1568 SALSRFASVKNTTPAGTPSSGGSSGGAIGKKSMSTTNLVDERQKTSGPSVASTGQAASAESLQHQ 1632

  Rat  1401 STKTERRSEIVMEHSIVSGADVHEPIVVLSSAENVPQTEVGSSSSASTSTLTAETGSENAERKLG 1465
            :...|......|.|:....|:..||       |:.|.....|.|:||..:
 Worm  1633 TPSLENLLARAMPHAFGRIAENQEP-------EDEPMGGEESDSAASMRS--------------- 1675

  Rat  1466 PDSSVRAPGESSAISMGIVSVSSPDVSSVSELTNKEAASQRPLSSSASNR-LSVSS--LLAAGAP 1527
                  |...:|.:|||  |.|.......|::|.:::|..........|: ||||:  |.||...
 Worm  1676 ------AASSNSQMSMG--SSSQQQQQQDSDMTPRDSAGTPSTPRDDKNQTLSVSAPDLAAARQR 1732

  Rat  1528 MSSSASVPNLSSRETSSLESFVRRVANIARTNATNNMNLSRSSSDNNTNTLGRNVMSTATSPLMG 1592
            .:|:.:..:..:.||:|.:..|.....:...:............|::.:....|........|:|
 Worm  1733 QASAETDGDADADETNSEDKTVGADDAMEEDDEEEETMEDEEDDDDDDDDESSNENQEKLVELLG 1797

  Rat  1593 AQS--FPNLTTPGTTSTVTMSTSSVTSSSNVATATTVLSVGQSLSNTLTTSLTSTSSESDTGQEA 1655
            .:.  |..|....|..    |.|..:||:..||.......|..........::|.:.......:.
 Worm  1798 GERGLFDKLKEVITGE----SLSDASSSAKDATTNEAQKKGGKKPKKWFKKMSSYTDVLKGLMQN 1858

  Rat  1656 EYSLYDFLDSCRASTLLAELDDDEDLPEPDEEDDENEDDNQEDQEYEEVMILRRP--SLQRRAGS 1718
            .|.: ..||...|...:.|:.||:|..: ..||..::.|:.||   |....|..|  |......:
 Worm  1859 RYPV-ALLDPAAAGIEMDEMMDDDDYYD-FSEDGPDDGDSVED---EVAAHLGMPVDSFASMVAA 1918

  Rat  1719 RSDVTHHAVTSQLPQVPSGAGSRPIGEQEEEEYETKGGRRRTWDDDYVLKRQFSALVPAFDPRPG 1783
            |:.:|..    |..::.||:..    |:..........|...|:||..:|..|.||:||||||||
 Worm  1919 RTPITWR----QFSELMSGSNR----ERAAMARAVASSRGSPWEDDATVKCTFEALIPAFDPRPG 1975

  Rat  1784 RTNVQQTTDLEIPPPGTPHSELLEEVECTPS--------PRLALTLKVTGLGTTREVELPLSNFR 1840
            |:||.||.::|:|       .::::...|.:        .::...|:...:.....|.:.:::..
 Worm  1976 RSNVNQTLEVELP-------TVVKDFGSTKASSSKIDKDDQMRFFLRGPNMSGVDNVTIEMNDDS 2033

  Rat  1841 STIFYYVQKLLQLSCNGNVKSDKLRRIWEPTYTIMYREMKDSDKEKENGKMGCWSIEHVEQYLGT 1905
            :::|.|:| ::..|.|...|||:.||||||||:|.|                |
 Worm  2034 ASLFRYMQ-IINNSVNWATKSDRSRRIWEPTYSICY----------------C------------ 2069

  Rat  1906 DELPKNDLITYLQKNADAAFLRHWKLTGTNKSIRKNRNCSQLIAAYKDFCEHGTRSGLNQGASSS 1970
                          :||.          ||..:.|
 Worm  2070 --------------SADQ----------TNVEVSK------------------------------ 2080

  Rat  1971 LQSSDILNLTKEQPQAKAGNGQNPCGVEDVLQLLRILYIVASDPYSRISQEDGDEQPQFTFPPDE 2035
                    :..|:       ...||.|...|:.:.:|        |||.|    ..|:....|:.
 Worm  2081 --------IPDEE-------SSTPCQVNQCLETIGLL--------SRIQQ----AMPEAEITPNV 2118

  Rat  2036 FTSKKITTKILQQIEEPLALASGALPDWCEQLTSKCPFLIPFETRQLYFTCTAFGASRAIVWLQN 2100
            |.|.|:|.|:.|.:.:.|.:|:.:||:||.:|..|.|.|...|||.:|...||||.||.|||||.
 Worm  2119 FISDKLTLKVTQVLSDALVVAARSLPEWCSRLVYKYPCLFTVETRNMYMQATAFGVSRTIVWLQQ 2183

  Rat  2101 RREATVERTR------TTSSVRRDDP-GEFRVGRLKHERVKVPRG-ESLMEWAENVMQIHADRKS 2157
            ||:|.|||.|      .:|:.|:.|. .|:|||||:||||||.|. |:|::.|..:|:.|||||:
 Worm  2184 RRDAAVERARGSAQAGNSSAARQHDRYHEYRVGRLRHERVKVTRAEETLLDQAIRLMKFHADRKA 2248

  Rat  2158 VLEVEFLGEEGTGLGPTLEFYALVAAEFQRTDLGTWLCDDNFPDD-------ESRHVDLGGGLKP 2215
            |||:|:..|||||||||||||||||||.||..|..|:|||   ||       |.|.||||.|.||
 Worm  2249 VLEIEYTNEEGTGLGPTLEFYALVAAELQRKSLALWVCDD---DDTHASKSGEEREVDLGEGKKP 2310

  Rat  2216 PGYYVQRSCGLFTAPFPQDSDELERITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMC---MG 2277
            .||||:|..|||.||.|..:||.:|...:|..||:||||.:.|.||||||:|:||.||:.   :|
 Worm  2311 IGYYVRRVGGLFPAPLPPGTDETKRAADMFRVLGVFLAKVLLDGRLVDLPLSRPFLKLLVHPQIG 2375

  Rat  2278 DIKSNMSKLIYESRGDRDLHCTESQSEASTEEGHDSLSVGSFEEDSKSEFILDPPKPKPPAWFNG 2342
            |          ::||. :||                                            .
 Worm  2376 D----------DARGP-NLH--------------------------------------------K 2385

  Rat  2343 ILTWEDFELVNPHRARFLKEIKDLAIKRRQILGNKSLSEDEKNTKLQELVLKNPSGSGPPLSIED 2407
            ||:.:|||.|||.:..||||::.||.::|.|..:.|:..:.|..|:.||.|..   .|....:||
 Worm  2386 ILSLDDFEEVNPVKGSFLKELRALAQRKRLIENDTSIDSNSKRRKIAELKLHI---KGSTCRVED 2447

  Rat  2408 LGLNFQFCPSSRIYGFTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDGFNKV 2472
            |.|||...|.|:::.:..::|...|.|..:|:||.|:||:...:|.::|||..||.||||||::|
 Worm  2448 LALNFTVNPPSKVFQYAEMELVDGGSDIDVTIDNVEQYVEKCEEFYLNTGIAYQMRAFRDGFDRV 2512

  Rat  2473 FPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRFVRVLCGMSSDERKA 2537
            ||:..|.::|.||||.:|.|.|.|.|:.:||:|||||||||||:||||||||.|:..:::.|||.
 Worm  2513 FPLRTLRAYSPEEVQRLLSGEQCPEWSRDDILNYTEPKLGYTRESPGFLRFVDVMEALTAQERKN 2577

  Rat  2538 FLQFTTGCSTLPPGGLANLHPRLTVVRKVDATDASYPSVNTCVHYLKLPEYSSEEIMRERLLAAT 2602
            ||||.||||:||||||||||||||:||||::.|.|||||||||||||||||||..|:|||||.|.
 Worm  2578 FLQFATGCSSLPPGGLANLHPRLTIVRKVESGDGSYPSVNTCVHYLKLPEYSSSAILRERLLTAI 2642

  Rat  2603 MEKGFHLN 2610
            .|||||||
 Worm  2643 NEKGFHLN 2650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hectd1	XP_006240148.1	Ank_2	366..457	CDD:289560	62/90 (69%)
		ANK repeat	366..393	CDD:293786	16/26 (62%)
		ANK	369..479	CDD:238125	75/112 (67%)
		ANK repeat	396..426	CDD:293786	19/29 (66%)
		ANK repeat	428..457	CDD:293786	23/28 (82%)
		F5_F8_type_C	1107..1240	CDD:304887	77/134 (57%)
		MIB_HERC2	1277..1335	CDD:284184	29/94 (31%)
		HECTc	2131..2608	CDD:238033	242/487 (50%)
		HECTc	2155..2607	CDD:214523	228/461 (49%)
hecd-1	NP_001368365.1	Ank_2	345..436	CDD:403870	62/90 (69%)
		ANK repeat	345..372	CDD:293786	16/26 (62%)
		ANK repeat	374..403	CDD:293786	19/28 (68%)
		PTZ00322	383..>497	CDD:140343	67/115 (58%)
		ANK repeat	405..436	CDD:293786	23/30 (77%)
		F5_F8_type_C	1243..1365	CDD:419973	72/125 (58%)
		MIB_HERC2	1452..1509	CDD:399589	29/56 (52%)
		HECTc	2221..2648	CDD:238033	242/487 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C162952360
Domainoid	1	1.000	415	1.000	Domainoid score	I350
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9115
Inparanoid	1	1.050	1177	1.000	Inparanoid score	I92
OMA	1	1.010	-	-		QHG52632
OrthoDB	1	1.010	-	-		D10145at33208
OrthoFinder	1	1.000	-	-		FOG0006411
OrthoInspector	1	1.000	-	-		oto28049
orthoMCL	1	0.900	-	-		OOG6_107049
Panther	1	1.100	-	-	LDO	PTHR45670
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4675
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.860