DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zip48C and SLC39A11

DIOPT Version :9

Sequence 1:	NP_610712.1	Gene:	Zip48C / 36273	FlyBaseID:	FBgn0033665	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_001153242.1	Gene:	SLC39A11 / 201266	HGNCID:	14463	Length:	342	Species:	Homo sapiens

Alignment Length:	356	Identity:	192/356 - (53%)
Similarity:	234/356 - (65%)	Gaps:	31/356 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIPGYGPVTQALLGTLLTWGLTAAGAALVIFVRGNQRRSLDAALGFAAGVMIAASFWSLLKPAIE 65
            |:.|:..|.||||||..|||:||||||||......|||.||.:||||||||:|||:||||.||:|
Human     1 MLQGHSSVFQALLGTFFTWGMTAAGAALVFVFSSGQRRILDGSLGFAAGVMLAASYWSLLAPAVE 65

  Fly    66 MAESSHLYGVYAFLPVAGGFLLGSIFVYGCDKLMSYLGL---NSTNMMIQM--TQSKAKAD---- 121
            ||.||..:|.:||.|||.||.||:.|||..|.||.:||.   ..|.:.:..  |..|.|:|
Human    66 MATSSGGFGAFAFFPVAVGFTLGAAFVYLADLLMPHLGAAEDPQTTLALNFGSTLMKKKSDPEGP 130

  Fly   122 -IAIEDSK------RNGVAPDRLASKSLDSFSDCLSVQHSGESRRRKKGASINEMEQCTYTTPEE 179
             :...:|:      |.|:..|:               ..:||:.:|||.|:....|......|..
Human   131 ALLFPESELSIRIGRAGLLSDK---------------SENGEAYQRKKAAATGLPEGPAVPVPSR 180

  Fly   180 QQRAEDALSQWKRIMLLVVAITVHNIPEGLAVGVSFGAIGSTNSSTFESARNLAIGIGIQNFPEG 244
            ...|:...|.|:||.||::|||:||:||||||||.||||..|.|:||||||||||||||||||||
Human   181 GNLAQPGGSSWRRIALLILAITIHNVPEGLAVGVGFGAIEKTASATFESARNLAIGIGIQNFPEG 245

  Fly   245 LAVSLPLHAAGFSVKRALWYGQLSGMVEPIFGVLGAVAVTFANLILPYALSFAAGAMIYIVSDDI 309
            |||||||..||||..||.|||||||||||:.||.||.||..|..||||||:||||||:|:|.|||
Human   246 LAVSLPLRGAGFSTWRAFWYGQLSGMVEPLAGVFGAFAVVLAEPILPYALAFAAGAMVYVVMDDI 310

  Fly   310 LPEAHASGNGTIATWGTVSGFLIMMCLEVAL 340
            :|||..||||.:|:|.::.||::||.|:|.|
Human   311 IPEAQISGNGKLASWASILGFVVMMSLDVGL 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zip48C	NP_610712.1	ZupT	23..340	CDD:223505	178/332 (54%)
SLC39A11	NP_001153242.1	ZupT	6..342	CDD:223505	190/351 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155639
Domainoid	1	1.000	305	1.000	Domainoid score	I1374
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12331
Inparanoid	1	1.050	347	1.000	Inparanoid score	I2305
Isobase	1	0.950	-	0	Normalized mean entropy	S3119
OMA	1	1.010	-	-		QHG55224
OrthoDB	1	1.010	-	-		D398036at33208
OrthoFinder	1	1.000	-	-		FOG0001712
OrthoInspector	1	1.000	-	-		oto89381
orthoMCL	1	0.900	-	-		OOG6_100747
Panther	1	1.100	-	-	LDO	PTHR11040
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3626
SonicParanoid	1	1.000	-	-		X3669
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750