Protein Alignment MCPH1 and BARD1

DIOPT Version :10

• Sequence 1: NP_001163123.1
• Gene: MCPH1 / 36272
• FlyBaseID: FBgn0260959
• Length: 1028
• Species: Drosophila melanogaster
• Sequence 2: NP_973758.2
• Gene: BARD1 / 839329
• AraportID: AT1G04020
• Length: 713
• Species: Arabidopsis thaliana
• Alignment Length: 863
• Identity: 143/863 - (16%)
• Similarity: 277/863 - (32%)
• Gaps: 340/863 - (39%)

  Fly   228 FKDGLLSTYKK---ATEWNIPVVSILWIEACKVQLKI---CDPKQFPISNIRMYEYPELFGKMPR 286
            |.:.::|.||.   |...::|            ||:|   |:.|...::|....::.|
plant    76 FMESVISIYKSLNAAVSVHLP------------QLQIPNDCNYKNDALNNSNSPKHGE------- 121

  Fly   287 VKFMQPDSELNQR--PRKRQGTPTSSKDNEPGSTNKRAQTGTPTTTTPKN--------------- 334
                ..|||:..:  .::..||.:||:|..|..|::.:.      ..||:
plant   122 ----SEDSEMTDKDVSKRSGGTDSSSRDGSPLPTSEESD------PRPKHQDWTEKQLSDHLLLY 176

  Fly   335 DISRFFRAINHNKPS----------DDEAIESPATKLLNRISSGCY----TPLPAGGTPQLMGTN 385
            :....:.|.||...|          |..|.|.|:.....||....:    :|.|....|.|:
plant   177 EFESEYDAANHTPESYTEQAAKNVRDITASEQPSNAARKRICGDSFIQESSPNPKTQDPTLL--- 238

  Fly   386 GSGDAVAQKVQAQKSLQFGEQTDSNTPQAKPSSTSRPRRSTVDPPPVMTPPVRTTRRRSCVAEIS 450
                      :..:||    ::|..|...|..:...|:..|...         :.|:|...|  |
plant   239 ----------RLMESL----RSDDPTDYVKAQNHQLPKSHTEQD---------SKRKRDITA--S 278

  Fly   451 SPAATDTRMTRRRSSLLTSTVIHEADPTQTAVAEPRMTRRRSSLLGIAKQAEETAQRQTIQPITE 515
            .......::.:|.::|:..:...:.:...:|.::.:::.:      |:|..|:|:...||....:
plant   279 DAMENHLKVPKRENNLMQKSADIDCNGKCSANSDDQLSEK------ISKALEQTSSNITICGFCQ 337

  Fly   516 ELAPVEENRNSII------------MAETNIIN-NTNCLEQSIEITAVEAEASFKADRRGTLYAS 567
            . |.|.|....::            :..:|:|: ::.|:|.:.::       .::.|....|.|
plant   338 S-ARVSEATGEMLHYSRGRPVDGDDIFRSNVIHVHSACIEWAPQV-------YYEGDTVKNLKA- 393

  Fly   568 ELMDISSPRRRSVAKSSLE----------LRQENLAPRARQSLSNVTTQTSFLDVEQQVTPLFSS 622
               :::...:....|.||:          .|:....|.||:..........||    .:.|..||
plant   394 ---ELARGMKIKCTKCSLKGAALGCFVKSCRRSYHVPCAREISRCRWDYEDFL----LLCPAHSS 451

  Fly   623 TRLPTGQTTGNRRRTIFNMDMDVINESIERMNQSHRMSLALANKAELGESCQVHEQEPPQAEPVP 687
            .:.|                    ||     ...||:|                     :|||:|
plant   452 VKFP--------------------NE-----KSGHRVS---------------------RAEPLP 470

  Fly   688 SQEPKRRRLFNPNDEVVISPAMSNRKSRLSITGSGSSSSVQKRRRSLATPAKSSSSELCATTPLS 752
            .                |:||                                   |||
plant   471 K----------------INPA-----------------------------------ELC------ 478

  Fly   753 KAVTNKEAEKSKSNTEISEASLDAVPEVKKSTSNAGEENEKPKGKSRTRIRTLVHTNMHQEQINV 817
                                ||:..|...|.....|....|..
plant   479 --------------------SLEQTPAFTKELVLCGSALSKSD---------------------- 501

  Fly   818 IRKALRKLRGMRLDPTVTQH----TTHLVSLEPR-----RTLNLLRGLMRGVWIVSYQWVLASIR 873
              |.|.:...:|.:.|::::    .||:::....     |||.:|.|::.|.||::..|:.||::
plant   502 --KKLMESLAVRFNATISRYWNPSVTHVIASTDEKGACTRTLKVLMGILNGKWIINAAWMKASLK 564

  Fly   874 AGKWINEEPYELTRFSRAIEICRTERQAFGVHYQC---ELFRFMEPFYVSSLCRPVQFNNMKELL 935
            |.:.::|||:|:...::.   |:...:...:..:.   :||..::.::.....:..: .:::.|:
plant   565 ASQPVDEEPFEIQIDTQG---CQDGPKTARLRAETNKPKLFEGLKFYFFGDFYKGYK-EDLQNLV 625

  Fly   936 LLGGATL--TENRFKAKYI--IGDKRRAEDDRVYLDP---------------------------- 968
            .:.|.|:  ||:...|:..  :.|:|.:......:||
plant   626 KVAGGTILNTEDELGAESSNNVNDQRSSSIVVYNIDPPHGCALGEEVTIIWQRANDAEALASQTG 690

  Fly   969 ------YWVLDSITNMQI 980
                  .|||:||...::
plant   691 SRLVGHTWVLESIAGYKL 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MCPH1	NP_001163123.1	BRCT_microcephalin_rpt1	186..260	CDD:349348	7/34 (21%)
		BRCT_microcephalin_rpt2	803..878	CDD:349368	18/83 (22%)
		BRCT_microcephalin_rpt3	905..980	CDD:349382	17/115 (15%)
BARD1	NP_973758.2	RING_Ubox	<33..72	CDD:473075
		rad18	35..>262	CDD:273165	44/231 (19%)
		ePHD	359..449	CDD:277046	17/104 (16%)
		BRCT_Bard1_rpt1	490..569	CDD:349366	20/102 (20%)
		BRCT_Bard1_rpt2	601..707	CDD:349352	17/106 (16%)